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| 1 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 2 | Neogenin-loss in neural crest cells results in persistent hyperplastic primary vitreous formation显示文摘Neogenin is a transmembrane receptor critical for multiple cellular processes,including neurogenesis,astrogliogenesis,endochondral bone formation,and iron homeostasis.Here we present evidence that loss of neogenin contributes to pathogenesis of persistent hyperplastic primary vitreous(PHPV)formation,a genetic disorder accounting for^5% of blindness in the USA.Selective loss of neogenin in neural crest cells(as observed in Wntl-Cre;Neofff mice),but not neural stem cells(as observed in GFAP-Cre and Nestin-Cre;Neo^f/f mice),resulted in a dysregulation of neural crest cell migration or delamination,exhibiting features of PHPV-like pathology(e.g.elevated retrolental mass),unclosed retinal fissure,and microphthalmia.These results demonstrate an unrecognized function of neogenin in preventing PHPV pathogenesis,implicating neogenin regulation of neural crest cell delamination/migration and retinal fissure formation as potential underlying mechanisms of PHPV. | Sen Lin Wei Liu Chun-Lin Chen Dong Sun Jin-Xia Hu Lei Li Jian Ye Lin Mei Wen-Cheng Xiong | 2020 | Journal of Molecular Cell Biology2020，12，1： | 3 |
| 3 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 4 | 显示文摘 | Yang Juan Mei Sen Ferreira J M F | 2001 | J Am Ceram Soc2001，84，8： | 1 |
| 5 | Fabrication of Rutile Rod-like Particle by Hydrothermal Method:An Insight into HNO3 Peptization显示文摘 | YANG Juan MEI Sen JOS M F | 2005 | J Collid Inter Sci2005，283，： | 1 |
| 6 | The densification and morphology of cordierite-based glass-ceramics显示文摘 | Sen Mei Juan Yang José M.F. Ferreira | 2001 | Materials Letters2001，，： | 1 |
| 7 | Aqueous tape casting processing of low dielectric constant cordierite-based glass-ceramics-Selection of binder显示文摘 | MEI Sen YANG Juan XU Xin Sandra Q Simeon A Ferreirajose M F | 2006 | J Euro Ceram Soc2006，26，12： | 1 |
| 8 | Hydrothermal processing of nanocrys- talline anatase films from tetraethylammonium hydroxide peptized titania sols 显示文摘 | Yang Juan Mei Sen Ferreira J M F | 2004 | J Eur ceram Soc2004，24，2： | 1 |
| 9 | The densification and morphology of cordierite-based glass-ceramics显示文摘 | MEI Sen YANG Juan FERREIRA Jose M F | 2001 | Mater Lett2001，47，45： | 1 |
| 10 | Sol-gel derived P2O5-doped cordierite powders:characterization and phase transformation显示文摘 | MEI Sen YANG Juan FERREIRA JOSE M F | 2001 | Materials Research Bulletin2001，36，： | 1 |
| 11 | The densification and morphology of cordierite-based glass ceramics显示文摘 | Sen Mei Juan Yang Jose Ferreira M F | 2001 | Materials Letters2001，47，4： | 1 |
| 12 | Hydrothermal synthesis of nanosized titania powders: influence of tetraalkyl ammonium hydroxides on particle characteristics 显示文摘 | Yang Juan Mei Sen Ferreira Jose M F | 2001 | J Am Ceram Soc2001，84，8： | 1 |
| 13 | 显示文摘 | Yang Juan Mei Sen Ferreira Jose'M F | 2004 | Journal of Collid and Inerface Science2004，，12： | 1 |
| 14 | Fabrication of Rutile Rod-like Particle by Hydrothermal Method:an Insight into HNO3 Peptization 显示文摘 | Yang Juan Mei Sen Ferrei Jose M F | 2005 | Journal of Colloid and Interface Science2005，283，： | 1 |
| 15 | Fecal Nucleic Acid Test as a Complementary Standard for Cured COVID-19 Patients显示文摘To date,no vaccine or specific antiviral treatment is yet available for COVID-19.The most effective control measures for the disease mainly depend on early diagnosis,strict patient quarantine,and close contact monitoring[1].Thus,reliable and accurate diagnostic methods play a critical role in global disease control and prevention.Reverse transcription-polymerase chain reaction(RT-PCR)assays are widely used for the laboratory diagnosis of virus-borne diseases. | HAN Mei ZOU Jing Bo LI Huan WEI Xiao Yu YANG Song ZHANG Hui Zheng WANG Peng Sen QIU Qian WANG Le Le CHEN Yao Kai PAN Pin Liang | 2020 | Biomedical and Environmental Sciences2020，33，12： | 1 |
| 16 | Colloidal processing of cordierite-based glass-ceramics显示文摘 | MEI Sen YANG Juan FERREIRA J M | 2001 | Int J Inorg Mater2001，3，： | 1 |
| 17 | Divergent responses of soil carbon and nitrogen pools to short-term nitrogen addition between two plantations in Northeast China显示文摘Nitrogen(N)deposition has a profound influence on forest soil carbon(C)and N pools,but there was no consensus on the responses of different C and N components in different forest types.In this study,a two-year simulated N deposition experiment with four levels of N(NH4NO3)-addition treatments(0,50,100,and 150 kg N/hm^(2)·a)were conducted in Larix gmelinii(LG)and Quercus mongolica(QM)plantation in Northeast China,in order to investigate the C and N pool dynamics under continuously enhanced N deposition.Soil organic carbon(SOC),soil total N(STN)and their active components(readily oxidizable C,ROC;dissolved organic C,DOC;microbial biomass C,MBC,dissolved organic N,DON;microbial biomass N,MBN)of the forest soil were measured monthly from May to October 2017.C and N contents in LG were observed higher than in QM.N addition had no effect on SOC and STN of LG,but significantly increased SOC and STN of QM at low N addition level.Low N addition generally raised active C components(ROC,DOC,and MBC)in both plantations,whereas high N addition did not significantly affect these components,or even decreased ROC in LG soil.Low N addition also increased STN and MBN of QM,while no significant change in STN and MBN of LG was observed.DON was directly affected by N addition and increased significantly with elevated N addition levels.The results indicated that N addition,especially of low rate,might enhance the C sequestration capacity of the forest soils and mitigate climate change. | Yedong Li Bo Wang Sen Dou Haoyue Shen Liyong Mei Yang Zhang Ximing Zeng Yaya Zhang Yameng Pei Haoye Ren Shimin Wu | 2019 | International Journal of Agricultural and Biological Engineering2019，12，6： | 1 |
| 18 | The densification and morphology of cordierite - based glass - ceramics 显示文摘 | Juan Yang Jose M F Ferreira | 2001 | Mater Lett2001，47，： | 1 |
| 19 | 显示文摘 | Mei Sen Yang Juan Jose Ferreira M F | 2001 | Mater Lett2001，47，45： | 1 |
| 20 | Comparison of Digital Radiographs with Film Radiographs for the Classification of Pneumoconiosis 1显示文摘 | Alfred Franzblau Ella A. Kazerooni Ananda Sen Mitchell M. Goodsitt Shih-Yuan Lee Kenneth D. Rosenman James E. Lockey Cristopher A. Meyer Brenda W. Gillespie E. Lee Petsonk Mei Lin Wang | 2009 | Academic Radiology2009，，： | 1 |
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