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| 1 | Helicobacter pylori in human health and disease:Mechanisms for local gastric and systemic effects显示文摘Helicobacter pylori(H. pylori) is present in roughly 50% of the human population worldwide and infection levels reach over 70% in developing countries. The infection has classically been associated with different gastro-intestinal diseases, but also with extra gastric diseases. Despite such associations, the bacterium frequently persists in the human host without inducing disease, and it has been suggested that H. pylori may also play a beneficial role in health. To understand how H. pylori can produce such diverse effects in the human host, several studies have focused on understanding the local and systemic effects triggered by this bacterium. One of the main mechanisms by which H. pylori is thought to damage the host is by inducing local and systemic inflammation. However, more recently, studies are beginning to focus on the effects of H. pylori and its metabolism on the gastric and intestinal microbiome. The objective of this review is to discuss how H. pylori has co-evolved with humans, how H. pylori presence is associated with positive and negative effects in human health and how inflammation and/or changes in the microbiome are associated with the observed outcomes. | Denisse Bravo Anilei Hoare Cristopher Soto Manuel A Valenzuela Andrew FG Quest | 2018 | World Journal of Gastroenterology2018，24，28： | 32 |
| 2 | Differential diagnosis in ulcerative colitis in an adolescent: Chronic granulomatous disease needs extra attention显示文摘Chronic granulomatous disease(CGD) is a primary immune deficiency that is commonly diagnosed under the age of 5 years(95%) and is rarely seen in adulthood. CGD may manifest as inflammatory bowel disease(IBD) in childhood. Without proper diagnosis, these patients may be monitored for years as IBD; some may even be regarded as steroid-resistant ulcerative colitis(UC) and end up having a colectomy. In this case report, we described a patient who had been followedup for years as UC and subsequently underwent colectomy, but was finally diagnosed in adulthood as primary immune deficiency. | Daniel Kotlarz Odul Egritas Gurkan Zehra Sule Haskologlu Ozgur Ekinci Aysel Aksu Unlusoy Neslihan Gürcan Kaya Jacek Puchalka Cristoph Klein Buket Dalgic | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，2： | 2 |
| 3 | Prediction of residual stresses and strains in cold- formed steel members显示文摘 | Cristopher Moen D Takeru I Schafer B W | 2008 | Thin-Walled Structures2008，46，： | 1 |
| 4 | Assessment of peri-extubation pain by visual analogue scale in the adult intensive care unit:a prespective observational study显示文摘 | Arnaud Gacouin Cristophe Camus Yves Le Tulzo | 2004 | Intensive care med2004，30，7： | 1 |
| 5 | Over-expression of ICAM-1,VCAM-1 and ELAM-1 might influence tumor progression in colorectal cancer显示文摘 | CRISTOPH A MAURE R FRIESS H | 1998 | Int J Cancer1998，79，1： | 1 |
| 6 | Experiments on cold-formed steel columns with holes显示文摘 | Cristopher D M Schafer B W | 2008 | Thin-Walled Structures2008，46，10： | 1 |
| 7 | On the long run implications of repeated moral hazard 显示文摘 | Cristopher P | 1998 | Journal of Economic Theory1998，79，2： | 1 |
| 8 | Effects of oral fat load on insulin output and glucose tolerance in healthy control subjects and obese patients without diabetes显示文摘 | Oliver Wuesten Cristoph H Reinhard G | 2005 | Diabetes Care2005，28，： | 1 |
| 9 | Logistics and competitive strategy显示文摘 | Cristopher M | 1993 | European Management Journal1993，，： | 1 |
| 10 | Finding com-munity structure in very large networks显示文摘 | Aaron Clauset Newman M E J Cristopher Moore | 2004 | Physical Review E2004，70，6： | 1 |
| 11 | MR imaging in pa tients with suspected liver metastases:value of liver specificcontrast agent GdEOB-DTPA显示文摘 | Cristoph J Karin A Herrmann et a1 | 2007 | Magn Reson Med Ci2007，6，： | 1 |
| 12 | On the computational power of DNA显示文摘 | Cristopher Dunworth Richard Lipton Jiri Sgall | 1995 | Technical Report1995，，： | 1 |
| 13 | Finding community structure in very large networks 显示文摘 | AARON C NEWMAN M E J CRISTOPHER M | 2004 | Physical Review: E Statistical Nonlinear Soft Matter Physics2004，70，6： | 1 |
| 14 | Highly selective receptive fields in 30 mouse visual cortex 显示文摘 | Cristopher M Tryker MP | 2008 | The Journal of Neuroscience2008，，28： | 1 |
| 15 | Directors and of cers' Liability In- surance: A Target or a Shield? 显示文摘 | Cristopher Parsons | 2000 | The Company Law- yer2000，，21： | 1 |
| 16 | Moral Hazard in Liability Insurance 显示文摘 | Cristopher Parsons | 2003 | The Geneva Papers on Risk and Insurance2003，，28： | 1 |
| 17 | Comparison of Digital Radiographs with Film Radiographs for the Classification of Pneumoconiosis 1显示文摘 | Alfred Franzblau Ella A. Kazerooni Ananda Sen Mitchell M. Goodsitt Shih-Yuan Lee Kenneth D. Rosenman James E. Lockey Cristopher A. Meyer Brenda W. Gillespie E. Lee Petsonk Mei Lin Wang | 2009 | Academic Radiology2009，，： | 1 |
| 18 | central role of PPARα in the mechanism of action of hepatocarcinogenic per oxisome proliferators显示文摘 | Cristopher J C Panla J L Frank J C | | Mutation Res0，448，： | 1 |
| 19 | Finding community structure in very large network显示文摘 | AARON C NEWMAN M E J CRISTOPHER M | 2004 | Physical Review E2004，70，6： | 1 |
| 20 | Arthroseopie assisted removal of retrograde I trameddulary femoral nails: Technique University Pennsy显示文摘 | Cristopher TB Paul JK Janet DH | 2000 | Orthop J2000，13，： | 1 |
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