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| 1 | Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment显示文摘Melanoma is the most aggressive form of skin cancer.Disrupted intracellular signaling pathways are responsible for melanoma's extraordinary resistance to current chemotherapeutic modalities. The pathophysiologic basis for resistance to both chemo- and radiation therapy is rooted in altered genetic and epigenetic mechanisms that, in turn, result in the impairing of cell death machinery and/or excessive activation of cell growth and survival-dependent pathways. Although most current melanoma therapies target mitochondrial dysregulation,there is increasing evidence that endoplasmic reticulum(ER) stress-associated pathways play a role in the potentiation,initiation and maintenance of cell death machinery and autophagy. This review focuses on the reliability of ER-associated pathways as therapeutic targets for melanoma treatment. | Mohamed Hassan Denis Selimovic Matthias Hannig Youssef Haikel Robert T Brodell Mossaad Megahed | 2015 | World Journal of Experimental Medicine2015，5，4： | 15 |
| 2 | Optimal Seat Suspension Design Using Genetic Algorithms显示文摘 | Wael Abbas Ossama B. Abouelatta Magdy El-Azab Mamdouh El-Saidy Adel A. Megahed | 2011 | Journal of Mechanics Engineering and Automation2011，1，1： | 3 |
| 3 | 添加Si/Ti对粉末冶金FiNiCrCo高熵合金物理力学和化学性能的影响显示文摘用粉末冶金法制备FiNiCrCoSi_(x)和FiNiCrCoTi_(x)高熵合金(HEAs)。其中x为0、0.3%、0.6%和0.9%(质量分数)。所有合金中均形成均匀分布的固溶体。与FiNiCrCo高熵合金相比,加入Si和Ti后,合金的密度和硬度提高,研究合金在不同载荷下的磨损率。结果表明,含0.3%Si和0.9%Ti的高熵合金磨损率最低。用XRD、SEM和EDX研究HEAs的相组或、晶粒尺寸和显微组织。通过H_(2)SO_(4)、HNO_(3)和HCl溶液浸泡实验,研究Si和Ti含量对烧结态FiNiCrCoSi_(x)和FiNiCrCoTi_(x) HEAs腐蚀行为和表面形貌的影响。在样品表面观察到不同尺寸的均匀腐蚀和局部点烛,且FiNiCrCoSi0.3合金具有更小,更少的蚀坑,和优异的显微组织。 | Sarah HEDYA Lamiaa MOHAMED Ghalia GABER Omayma ELKADY Hassan MEGAHED Shimaa ABOLKASSEM | 2022 | Transactions of Nonferrous Metals Society of China2022，32，8： | 2 |
| 4 | Investigation on Electron Beam Welded Copper to AISI 316 Stainless Steel Joints显示文摘Joints of copper and stainless steels are used in a er ospace applications. Production of these joints by fusion welding faces many dif ficulties. This may be due to the differences in their physical, metallurgical a nd mechanical properties. Electron Beam Welding (EBW) process has been found to be especially well suited in this area. Selection of the appropriate welding par ameters needs thorough investigations. These parameters include: preheat tempera ture (℃), welding current (I w), focusing current (I F), welding spee d (V), height between the gun and workpiece surface (H), scan width (S w) and shift distance (S). The present work aims firstly, setting the pr oper welding conditions to get sound joint between commercially pure copper (C10 200) and AISI 316 stainless steel plates 8 mm thickness. Secondly, investigate t he effect of Electron Beam (EB) shift, single-sided and double-sided welds on the mechanical, metallurgical and chemical properties of the weld bead. Due to t he high difference in thermal conductivity between copper and stainless steel, E lectron Beam (EB) was shifted towards copper with different values. These values were ranged from 0.3 to 0.9 mm in welding without preheating of copper plate an d from 0.1 to 0.4 mm with preheating. Number of joints were welded using variabl e EBW parameters in view to obtain the sound weld bead. These parameters are as follows: gradual reduction I w=51 to 49 mA, I F=845 mA, V=8 mm/sec , H=130 mm, S w=500 μm and S=0.4 mm. The investigation has shown t hat, the copper (C10200) plate must be preheated to get sound welded joint with AISI 316 stainless steel using the EBW process. The tensile fracture in all wel ded samples occurred in copper plate away from the weld bead. This reflects that the weld bead tensile strength is greater than the copper strength. The EB shif t has slight effect on hardness distribution through weld bead. The hardness val ue (H v) reduces in gradual manner from stainless steel hardness to copper one. The EB shift distance has no significant effect on the impact toughness. | El-Hebeary M R Megahed H Elziady N | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 2 |
| 5 | Variable fluid properties and variable heat flux effects on the flow and heat transfer in a non-Newtonian Maxwell fluid over an unsteady stretching sheet with slip velocity显示文摘The effects of variable fluid properties and variable heat flux on the flow and heat transfer of a non-Newtonian Maxwell fluid over an unsteady stretching sheet in the presence of slip velocity have been studied. The governing differential equations are transformed into a set of coupled non-linear ordinary differential equations and then solved with a numerical technique using appropriate boundary conditions for various physical parameters. The numerical solution for the governing non-linear boundary value problem is based on applying the fourth-order Runge-Kutta method coupled with the shooting technique over the entire range of physical parameters. The effects of various parameters like the viscosity parameter, thermal conductivity parameter, unsteadiness parameter, slip velocity parameter, the Deborah number, and the Prandtl number on the flow and temperature profiles as well as on the local skin-friction coefficient and the local Nusselt number are presented and discussed. Comparison of numerical results is made with the earlier published results under limiting cases. | Ahmed M. Megahed | 2013 | Chinese Physics B2013，22，9： | 2 |
| 6 | Synchronous generator internal fauh computation experimental verification 显示文摘 | MEGAHED A I MALIK O P | 1998 | tEE Proc - Gener Trans- actions on Distrib1998，145，5： | 1 |
| 7 | Variable viscosity and slip velocity effects on the flow and heat transfer of a power-law fluid over a non-linearly stretching surface with heat flux and thermal radiation 显示文摘 | MEGAHED A M | 2012 | Rheologica Acta2012，51，： | 1 |
| 8 | Simulation of internal faults in syn- chronous generators 显示文摘 | MEGAHED A I MALIK O P | 1999 | IEEE Transactions on Energy Conversion1999，14，4： | 1 |
| 9 | Papulonodular mucinosis associated with subacute cutaneous lupus erythematosus显示文摘 | Sonntag M Lehmann P Megahed M | | 0，，04： | 1 |
| 10 | A two-dimensional thermoelasticity problem for a half space subjected to heat sources显示文摘 | Sherief H H Megahed F A | 1999 | Internat J Solids and Structures1999，36，9： | 1 |
| 11 | Applications of iterative elastic techniques for elastic-plastic analysis of pressure vessels显示文摘 | MOHAMED A I MEGAHED M M BAYOUMI L S | 1999 | Journal of Pressure Vessel Technology1999，121，： | 1 |
| 12 | Histopathology of photodermatoses显示文摘 | Megahed M Schaller J | 2006 | Hautarzt2006，57，12： | 1 |
| 13 | Histopathoio^v ofphotodermatoses 显示文摘 | Megahed M Schalier J | 2006 | Haularzt2006，57，12： | 1 |
| 14 | SehonleinHenoch purpura associated with gastric Helicobactor pylori infection显示文摘 | Megahed M Goerz G | 1995 | J Am A''cad Dermatol1995，33，52： | 1 |
| 15 | ElectromagneticWaves Scattering by Nonuniform Plasma Cylinder显示文摘 | Helaly A Soliman E A Megahed A A | 1997 | IEEEProceeding Microwave Antennas Propagation1997，144，2： | 1 |
| 16 | Synchronous generator internal fault compu tation and experimental verification显示文摘 | Malik O P | 1998 | IEE Proceedings--Generation Trans mission and Distribution1998，145，5： | 1 |
| 17 | Characteristics of Starch-based Biodegradable Com-posites Reinforced with Date Palm and Flax Fibers 显示文摘 | Hamdy Ibrahim Mahmoud Farag Hassan Megahed etal | 2014 | Carbohydrate Polymers2014，，101： | 1 |
| 18 | Synergism of RAD and cyclosporin A in prevention of acute rat corneal allograft rejection 显示文摘 | Reis A Megahed M Reinhard T | 2002 | Cornea2002，21，1： | 1 |
| 19 | Tribological Characterization of Hybrid Metal Matrix Composites Processed by Powder Metallurgy显示文摘Aluminum(Al)-based aluminum oxide(Al_2O_3) and silicon carbide(SiC) particles hybrid metal matrix composites were processed by powder metallurgy technique, followed by sintering at 500 ℃ and then hot extrusion. The tribological properties of these composites with different weight fractions of Al_2O_3 and SiC were investigated; extrusion process significantly reduces the extent of porosity after cold compaction and sintering processes. Hybridization of the two reinforcements improved hardness and wear resistance of the composites. With an increase in SiC content, hardness was increased and consequently the wear resistance was enhanced also. Scanning electron microscopy observations show a better interfacial bond between matrix and reinforcements and a better distribution of the reinforcements. | M. Megahed M. A. Attia M. Abdelhameed A. G. El-Shafei | 2017 | Acta Metallurgica Sinica(English Letters)2017，30，8： | 1 |
| 20 | Hepatitis C virus-mediated angiogenesis:Molecular mechanisms and therapeutic strategies显示文摘Angiogenesis is an essential process for organ growth and repair. Thus, an imbalance in this process can lead to several diseases including malignancy. Angiogenesis is a critical step in vascular remodeling, tissue damage and wound healing besides being required for invasive tumor growth and metastasis. Because angiogenesis sets an important point in the control of tumor progression, its inhibition is considered a valuable therapeutic approach for tumor treatment. Chronic liver disease including hepatitis C virus(HCV) infection is one of the main cause for the development of hepatic angiogenesis and thereby plays a critical role in the modulation of hepatic angiogenesis that finally leads to hepatocellular carcinoma progression and invasion. Thus, understanding of the molecular mechanisms of HCV-mediated hepatic angiogenesis will help design a therapeutic protocol for the intervention of HCV-mediated angiogenesis and subsequently its outcome. In this review, we will focus on the molecular mechanisms of HCV-mediated hepatic angiogenesis and the related signaling pathways that can be target for current and under development therapeutic approaches. | Mohamed Hassan Denis Selimovic Abdelouahid El-Khattouti Martine Soell Hanan Ghozlan Youssef Haikel Ola Abdelkader Mosaad Megahed | 2014 | World Journal of Gastroenterology2014，20，42： | 1 |
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