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| 1 | Hexadecanoic acid-enriched extract of Halymenia durvillei induces apoptotic and autophagic death of human triple-negative breast cancer cells by upregulating ER stress显示文摘Objective:To investigate the effect of the hexane solvent fraction of Halymenia durvillei(HDHE)on triple-negative breast cancer.Methods:The phytochemical profile of HDHE was investigated by GC-MS.The cytotoxicity of HDHE against MDA-MB-231 cells was determined.The apoptotic and autophagic effects of HDHE were analyzed.The expression of molecular markers controlling apoptosis,autophagy,DNA damage,and endoplasmic reticulum(ER)stress was determined.Results:HDHE contains a mixture of fatty acids,mainly hexadecanoic acid.HDHE at a cytotoxic concentration induced apoptotic death of MDA-MB-231 cells through mitochondrial membrane dysfunction,and induction of apoptosis markers,and increased the expression of proteins related to DNA damage response.HDHE also induced the expression of LC-3,a marker of autophagic cell death at a cytotoxic concentration.Moreover,HDHE modulated the expression of ER stress genes.Conclusions:The hexadecanoic acid-enriched extract of Halymenia durvillei promotes apoptosis and autophagy of human triple-negative breast cancer cells.This extract may be further explored as an anticancer agent for triple-negative breast cancer. | Kant Sangpairoj Rapeewan Settacomkul Tanapan Siangcham Krai Meemon Nakorn Niamnont Nilubon Sornkaew Montakan Tamtin Prasert Sobhon Pornpun Vivithanaporn | 2022 | Asian Pacific Journal of Tropical Biomedicine2022，12，3： | 2 |
| 2 | 查看详情显示文摘 | Meemon P Lee K S Murali S Rolland J | | 0，，： | 1 |
| 3 | Dual detection full range frequency domain optical coherence tomography显示文摘 | K S Lee P Meemon W Dallas | | 0，，7： | 1 |
| 4 | Vaccine potential of recombinant cathepsin B against Fasciola gigantica显示文摘 | Chantree P Phatsara M Meemon K | 2013 | Exp Parasitol2013，135，1： | 1 |
| 5 | Molecular cloning and analysis of stage and tissue-specific expression of cathep-sin B encoding genes from Fasciola gigantica显示文摘 | Meemon K Grams R Vichasri-Grams S | 2004 | Mol Biochem Parasitol2004，136，1： | 1 |
| 6 | Doppler imaging with dual-detection full-range frequency domain optical coherence tomography显示文摘 | P Meemon K S Lee J P Rolland | 2010 | Biomed Opt Express2010，1，2： | 1 |
| 7 | Broadband Fourier-Domain Mode-Locked Lasers显示文摘宽带,高速度的打扫波长的激光能实质地在光连贯断层摄影术,化学光谱学,并且光纤的察觉到提高应用。我们报导在大约 90 kHz 操作的 Fourier 域模式锁激光的示范有效在 158 nm 上打扫率用一个单个乐队的图案打扫范围并且用一个唯一的宽带图案越过 1.3 m 在 284 nm 上打扫范围到 1.5 m 波长光谱。一个新奇双察觉的完整范围的 Fourier 域光连贯断层摄影术系统被开发它提供 7 m 轴的分辨率(在空中) 在大约 90 kHz,为镜像的轴的扫描率在一根人的手指和一条非洲的青蛙蝌蚪解决了 Doppler 成像。 | Kevin HSU Panomsak MEEMON Kye-Sung LEE Peter J. DELFYETT Jannick E ROLLAND | 2011 | Photonic Sensors2011，1，3： | 1 |
| 8 | Optical design of a dynamic focus catheter for high-resolution endoscopic optical coherence tomography 显示文摘 | MEEMON P LEE K MURALI S | 2008 | Applied Optics2008，47，13： | 1 |
| 9 | Molecular cloning and analysis of stage and tissue-specific expression of cathepsin B encoding genes from Fasciola gigantica显示文摘 | Meemon K Grams R Vichasri-Grams S | 2004 | Molecular & Biochemical Parasitology2004，136，： | 1 |
| 10 | 查看详情显示文摘 | V F Duma K S Lee P Meemon | | 0，，： | 1 |
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