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| 1 | Levofloxacin/amoxicillin-based schemes vs quadruple therapy for Helicobacter pylori eradication in second-line显示文摘Worldwide prevalence of Helicobacter pylori(H.pylori) infection is approximately 50%,with the highest being in developing countries.We compared cure rates and tolerability(SE) of second-line anti-H.pylori levofloxacin/amoxicillin(LA)-based triple regimens vs standard quadruple therapy(QT).An English language literature search was performed up to October 2010.A meta-analysis was performed including randomized clinical trials comparing 7-or 10-d LA with 7-d QT.In total,10 articles and four abstracts were identified.Overall eradication rate in LA was 76.5%(95% CI:64.4%-97.6%).When only 7-d regimens were included,cure rate was 70.6%(95% CI:40.2%-99.1%),whereas for 10-d combinations,cure rate was significantly higher(88.7%;95% CI:56.1%-109.9%;P < 0.05).Main eradication rate for QT was 67.4%(95% CI:49.7%-67.9%).The 7-d LA and QT showed comparable efficacy [odds ratio(OR):1.09;95% CI:0.63-1.87],whereas the 10-d LA regimen was significantly more effective than QT(OR:5.05;95% CI:2.74-9.31;P < 0.001;I 2 = 75%).No differences were reported in QT eradication rates among Asian and European studies,whereas LA regimens were more effective in European populations(78.3% vs 67.7%;P = 0.05).Incidence of SE was lower in LA therapy than QT(OR:0.39;95% CI:0.18-0.85;P = 0.02).A higher rate of side effects was reported in Asian patients who received QT.Our findings support the use of 10-d LA as a simple second-line treatment for H.pylori eradication with an excellent eradication rate and tolerability.The optimal second-line alternative scheme might differ among countries depending on quinolone resistance. | Simona Di Caro Lucia Fini Yayha Daoud Fabio Grizzi Antonio Gasbarrini Antonino De Lorenzo Laura Di Renzo Sara McCartney Stuart Bloom | 2012 | World Journal of Gastroenterology2012，18，40： | 9 |
| 2 | Impact of alcohol on hepatitis C virus replication and interferon signaling显示文摘Hepatitis C virus (HCV) is one of the main etiological factors responsible for liver disease worldwide. It has been estimated that there are over 170 million people infected with HCV worldwide. Of these infected individuals, approximately 75% will go on to develop a life long necroinflammatory liver disease, which over decades, can result in serious complications, such as cirrhosis and hepatocellular carcinoma. Currently there is no effective vaccine and whilst antiviral therapies have been improved, they are still only effective in approximately 50% of individuals. HCV infection stands as a major cause of global morbidity and suffering, and places a signifi cant burden on health systems. The second highest cause of liver disease in the western world is alcoholic liver disease. Frequently, HCV infected individuals consume alcohol, and the combined effect of HCV and alcohol consumption is deleterious for both liver disease and response to treatment. This review discusses the impact of alcohol metabolism on HCV replication and the negative impact on interferon (IFN)-α treatment, with a particular focus on how alcohol and HCV act synergistically to increase oxidative stress, ultimately leading to exacerbated liver disease and a reduction in the effi cacy of IFN-α treatment. A better understanding of the complicated mechanisms at play in hepatocytes infected with HCV and metabo- lizing alcohol will hopefully provide better treatment options for chronic hepatitis C individuals that consume alcohol. | Erin M McCartney Michael R Beard | 2010 | World Journal of Gastroenterology2010，16，11： | 5 |
| 3 | The effect of electromagnetic stirring during solidification on the structure of Al-Si alloys显示文摘 | W.D. Griffiths D.G. McCartney | 1996 | Materials Science & Engineering A1996，，1： | 5 |
| 4 | A comparison of the abrasive wear behaviour of HVOF sprayed titanium carbide- and titanium boride-based cermet coatings显示文摘 | M Jones A.J Horlock P.H Shipway D.G McCartney J.V Wood | 2001 | Wear2001，，1： | 3 |
| 5 | Biochemical regulation of pigment motility in vertebrate chromatophores: a review of physiological color change mechanisms显示文摘 | Russell A. LIGON Kristen L. MCCARTNEY | 2016 | Current Zoology2016，62，3： | 3 |
| 6 | Abrasive wear behaviour of Ni(Cr)–TiB 2 coatings deposited by HVOF spraying of SHS-derived cermet powders显示文摘 | B. Lotfi P.H. Shipway D.G. McCartney H. Edris | 2003 | Wear2003，，3： | 2 |
| 7 | Systemic inflammatory response is a predictor of outcome in patients undergoing preoperative chemoradiation for locally advanced rectal cancer显示文摘 | R. Carruthers L. M. Tho J. Brown S. Kakumanu E. McCartney A. C. McDonald | 2012 | Colorectal Disease2012，，10： | 2 |
| 8 | Mechanics of matrix cracking in brittle-matrix fiber reinforced composites显示文摘 | McCartney L N | 1987 | Proc R Soc Lond1987，409，： | 2 |
| 9 | Effects of a high- salt diet on hepatic atrial natriuretic peptide receptor expression in Dahl salt- resistant and salt - sensitive rats显示文摘 | McCartney S Cramb G | 1993 | J Hypertens1993，11，： | 2 |
| 10 | Observations on the microstructure and performance of an Al-Ti-C grain-refining master alloy显示文摘 | McCartney D G Tatlock G J | 1994 | Materials Sceince and Engineering1994，188，： | 1 |
| 11 | Hypothalamic dysfunction显示文摘 | Eagleson CA McCartney CR | 2001 | Mol Cell Endocrinol2001，183，12： | 1 |
| 12 | Sliding wear behavior of HVOF sprayed WC-Co coatings deposited with both gas-fuelled and liquid-fuelled systems 显示文摘 | Sudaprasert T Shipway P H McCartney D G | 2003 | Wear2003，255，712： | 1 |
| 13 | Abrasive wear behaviour of Ni( Cr)-TiB2 coatings deposit-ed by HVOF spraying of SHS-derived cermet powders 显示文摘 | Lotfi B Shipway P H McCartney D G | 2003 | Wear2003，254，： | 1 |
| 14 | Feasibility and safety of total hparoscopic radical hysterectomy 显示文摘 | Obermair A Ginbey P McCartney A | 2003 | J Am Assoc Gynecol Lapamsc2003，10，3： | 1 |
| 15 | Mapping of three antigenic sites on the hemagglutinin-neuraminidase protein of Newcastle disease virus显示文摘 | YusoffK Nesbit M McCartney H | 1988 | Virus Res1988，11，： | 1 |
| 16 | The flattening of triangulated surfaces in corporating darts and gussets 显示文摘 | MCCARTNEY J HINDS B K SEOW B L | 1999 | Computer Aided Design1999，31，： | 1 |
| 17 | Progesterone inhibition of the hypothalamic gonadotropin-releasing hormone pulse generator: evidence for varied effects in hyperandrogenemic adolescent glrls显示文摘 | Chhabra S McCartney CR Yoo RY | 2005 | J Clin Endocrinol Metab2005，90，5： | 1 |
| 18 | Total laparescopic hysterectomy in the management of endometrial carcinoma 显示文摘 | Manolitsas TP McCartney AJ | 2002 | J Am Assoc Gynecol Laparesc2002，9，7： | 1 |
| 19 | An in vitro study of the probiotic potential of a bile-salt-hydrolyzing lactobacillus fermentum strain,and determination of its cholesterol-lowering properties显示文摘 | Pereira DIA McCartney AL Gibson GR | | 0，，08： | 1 |
| 20 | Interactive garment design显示文摘 | B. K. Hinds J. McCartney | 1990 | The Visual Computer1990，，2： | 1 |
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