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| 1 | Pancreatic enzymes and abdominal adipose tissue distribution in new-onset prediabetes/diabetes after acute pancreatitis显示文摘BACKGROUND New-onset prediabetes/diabetes after acute pancreatitis(NODAP)is the most common sequela of pancreatitis,and it differs from type 2 prediabetes/diabetes mellitus(T2DM).AIM To study the associations between circulating levels of pancreatic amylase,pancreatic lipase,chymotrypsin and fat phenotypes in NODAP,T2DM,and health.METHODS Individuals with NODAP(n=30),T2DM(n=30),and sex-matched healthy individuals(n=30)were included.Five fat phenotypes(intra-pancreatic fat,liver fat,skeletal muscle fat,visceral fat,and subcutaneous fat)were determined using the same magnetic resonance imaging protocol and scanner magnet strength for all participants.One-way analysis of covariance,linear regression analysis,and relative importance analysis were conducted.RESULTS Intra-pancreatic fat deposition(IPFD)was higher in NODAP(9.4%±1.8%)and T2DM(9.8%±1.1%)compared with healthy controls(7.8%±1.9%)after adjusting for covariates(P=0.003).Similar findings were observed in regards to visceral fat volume(P=0.005),but not subcutaneous fat volume,liver fat,or skeletal muscle fat.Both IPFD(β=-2.201,P=0.023)and visceral fat volume(β=-0.004,P=0.028)were significantly associated with circulating levels of pancreatic amylase in NODAP,but not in T2DM or healthy individuals.Of the five fat phenotypes,IPFD explained the highest amount of variance in pancreatic amylase concentration(R2=15.3%out of 41.2%).None of the phenotypes contributed meaningfully to the variance in pancreatic lipase or chymotrypsin.CONCLUSION Both NODAP and T2DM are characterized by increased IPFD and visceral fat volume.However,only NODAP is characterized by significant inverse associations between the two fat phenotypes and pancreatic amylase. | Juyeon Ko Loren Skudder-Hill Jaelim Cho Sakina H Bharmal Maxim S Petrov | 2021 | World Journal of Gastroenterology2021，27，23： | 5 |
| 2 | The β-lactam antibiotic, ceftriaxone, dramatically improves survival, increases glutamate uptake and induces neurotrophins in stroke显示文摘 | Christa Th?ne-Reineke Christian Neumann Pawel Namsolleck Kristin Schmerbach Maxim Krikov Jan H Schefe Kristin Lucht Heide H?rtnagl Michael Godes Susanne Müller Kay Rumschüssel Heiko Funke-Kaiser Arno Villringer U Muscha Steckelings Thomas Unger | 2008 | Journal of Hypertension2008，，12： | 2 |
| 3 | A Common Pesticide Decreases Foraging Success and Survival in Honey Bees显示文摘 | MICKAEL H MAXIME B FABRICE R | 2012 | Science2012，336，6079： | 1 |
| 4 | Population, time allocation and human capital:a general equilibrium analysis for Canada 显示文摘 | Maxime F Simon H Jean M | 2009 | Economic Modelling2009，26，： | 1 |
| 5 | The Ability of Stroke Volume Variations Obtained with Vigileo/FloTrac System to Monitor Fluid Responsiveness in Mechanically Ventilated Patients显示文摘 | Maxime Cannesson Henri Musard Olivier Desebbe Cécile Boucau Rémi Simon Roland Hénaine Jean-Jacques Lehot | 2009 | Anesthesia & Analgesia2009，，2： | 1 |
| 6 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 7 | Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking 显示文摘 | Maxime D H Camilla L C Philippe R | 2003 | Science2003，302，： | 1 |
| 8 | Clinical review: corticotherapy in sepsis显示文摘 | Prigent H Maxime V Annane D | 2004 | Crit Care2004，8，2： | 1 |
| 9 | Science review: mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids显示文摘 | PRIGENT H MAXIME V ANNANE D | 2004 | Crit Care2004，8，： | 1 |
| 10 | Multidisciplinary prac- tical guidelines for gastrointestinal access for enteral nutrition and decompression from the Society of Interventional Radiology and American Gastroenterological Association ( AGA ) Institute, with endorsement by Canadian Interventional Radiological Association (CIRA) and Cardiovascular and Interventional Radiological Socie- ty of Europe(CIRSE) 显示文摘 | MAXIM I MARK H D JOHN C F | 2011 | J Vasc Interv Radiol2011，22，8： | 1 |
| 11 | Changes of opening angle in hypertensive and hypotensive arteries in 3-day organ culture 显示文摘 | Han H C Maxim S Ku D N | 2006 | J Biomeeh2006，39，13： | 1 |
| 12 | Microwave-assisted dissolution and delignification of wood in 1-ethyl-3-methylimidazolium acetate显示文摘 | WANG H MAXIM M L GURAU G | 2013 | Bioresource Technology2013，136，： | 1 |
| 13 | Bifunctional Fe3O4/ZnS:Mn composite nanoparticles显示文摘 | JUAN B H MAXIME J F BRAD R W | 2013 | Material Letters2013，98，： | 1 |
| 14 | Fate of US and Canadian combustion nitrogen emissions显示文摘 | LEVY H MAXIM W | 1987 | Nature1987，328，： | 1 |
| 15 | Effects of growth horane treatment on oxygen consumption and seawater adaptability in Atlantic salmon parr and pre-smolts显示文摘 | Seddiki H Boeuf G Maxime V | 1996 | Aquaculture1996，148，： | 1 |
| 16 | An analysis of risks for biodiversity under the DPSIR framework显示文摘 | Maxim L Spangenberg J H OrConnor M | 2009 | Eco- logical Economics2009，69，1： | 1 |
| 17 | Acute pancreatitis and pregnancy:A 10-year single center experience 显示文摘 | Alejandro H Maxim SP David CB | 2007 | J Gastrointestinal Surgery2007，11，： | 1 |
| 18 | N-acetylgala ctosamine-functionalized dendrimers as hepatic cancer cell-targeted carriers显示文摘 | Medina Scott H Tekumalla Venkatesh Chevliakov Maxim V | 2011 | Biomaterials2011，32，17： | 1 |
| 19 | Fate of US and Canadian combustion nitrogen emissions显示文摘 | Levy H Maxim W J | 1987 | Nature1987，328，： | 1 |
| 20 | Mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids显示文摘 | Prigent H Maxime V Annane D | 2004 | Crit Care2004，8，4： | 1 |
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