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| 1 | Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis显示文摘The sequence of events associated with the development of gastric cancer has been described as 'the gastric precancerous cascade'. This cascade is a dynamic process that includes lesions, such as atrophic gastritis, intestinal metaplasia and dysplasia. According to this model, Helicobacter pylori(H. pylori) infection targets the normal gastric mucosa causing non-atrophic gastritis, an initiating lesion that can be cured by clearing H. pylori with antibiotics or that may then linger in the case of chronic infection and progress to atrophic gastritis. The presence of virulence factors in the infecting H. pylori drives the carcinogenesis process. Independent epidemiological and animal studies have confirmed the sequential progression of these precancerous lesions. Particularly long-term follow-up studies estimated a risk of 0.1% for atrophic gastritis/intestinal metaplasia and 6% in case of dysplasia for the long-term development of gastric cancer. With this in mind, a better understanding of the genetic and epigenetic changes associated with progression of the cascade is critical in determining the risk of gastric cancer associated with H. pylori infection. In this review, we will summarize some of the mostrelevant mechanisms and focus predominantly but not exclusively on the discussion of gene promoter methylation and mi RNAs in this context. | Manuel A Valenzuela Jimena Canales Alejandro H Corvalán Andrew FG Quest | 2015 | World Journal of Gastroenterology2015，21，45： | 33 |
| 2 | Carbon nanotubes as reinforcement of styrene-butadiene rubber 显示文摘 | Alejandro D F Silvia G Gerardo H R | 2007 | Applied Surface Science2007，254，1： | 1 |
| 3 | Use of compre- ssed fluids for sample preparation: food applications显示文摘 | Jos6 AM Miguel H Alejandro C | 2007 | J Chromatogr A2007，1152，12： | 1 |
| 4 | Volatile Organic Compounds from the Clone Populus x canadensis “Conti” Associated with Megaplatypus mutatus Attack显示文摘 | Alejandro Lucia Paola González-Audino Héctor Masuh Taya Chermenskaya | 2014 | Psyche2014，，： | 1 |
| 5 | Large-scale investigation of weed seed identification by machine vision显示文摘 | Pablo M Granitto Hugo D Navone Ceccatto H Alejandro | 2005 | Computers and Electronics in Agriculture2005，47，1： | 1 |
| 6 | Predictive control applied to heat-exchanger networks显示文摘 | GONZ′ALEZ Alejandro H ODLOAK Darci MARCHETTI Jacinto L | 2006 | Chemical Engineering and Processing2006，45，： | 1 |
| 7 | Polyacetylenes, terpenoids and flavonoids from Bupleurum spinosum 显示文摘 | Alejandro F B Ali H Munozedorado M | 1998 | Phytochem1998，48，7： | 1 |
| 8 | Peripheral neuropathy predicts nuclear gene defect in patients with mitochondrial ophthalmo- plegia显示文摘 | Alejandro H Pitceathly RDS Blake JC | 2014 | Brain A Journal of Neurology2014，137，： | 1 |
| 9 | Purification of apolyphenol oxidase isoform from potato (Solanum tuberosum )tubers 显示文摘 | Costanza M Alessandra F Alejandro H | 2003 | Phytochemistry2003，63，7： | 1 |
| 10 | Hilbert transform analysis of a time series of speckle interferograms with a temporal carrier显示文摘 | Fernando A Marengo Rodriguez Alejandro Federico Guillermo H Kaufmann | 2008 | Applied Optics2008，47，9： | 1 |
| 11 | Phenolic composition of skins from four Carmenet grape varieties ( Vitis vinifera L.) during ripening显示文摘 | Elías Obreque-Slier álvaro Pe?a-Neira Remigio López-Solís Alejandro Cáceres-Mella Héctor Toledo-Araya Américo López-Rivera | 2013 | LWT - Food Science and Technology2013，，： | 1 |
| 12 | Intra-abdominal hyper- tension: Incidence and association with organ dysfunction during early septic shock显示文摘 | Tomas R Alejandro B Pablo H | 2008 | Journal of Critical Care2008，23，4： | 1 |
| 13 | Current methodology for detection,identification and quantification of genetically modified organisms显示文摘 | MARTA H DAVID R L ALEJANDRO F | 2005 | Current Analytical Chemistry2005，1，2： | 1 |
| 14 | Treatment of As- pirin-Resistant Patients With Omega-3 Fatty Acids Ver-sus Aspirin Dose Escalation 显示文摘 | Eli I L Alejandro S Naama H | 2010 | Journal of the American College of Cardiology2010，55，2： | 1 |
| 15 | Effect of Membrane Permeability on Survival of Hemodialysis Patients显示文摘 | Francesco L Alejandro MM Thierry H | | 0，，： | 1 |
| 16 | Carbon nanotubes as reinforcement of styrene-butadiene rubber显示文摘 | Alejandro D F Silvia G Gerardo H R | 2007 | Applied Sur- face Science2007，254，1： | 1 |
| 17 | 中国医用气体工程质量控制建议(英文)显示文摘气体长期应用于世界各地的医疗领域。其中,医用氧是最重要的医用气体,在医院和家庭中广泛使用。医用氧被定义为药品,它的医用运输系统属于医疗器械范畴,其质量和管理应符合相关标准的要求。在中国,医疗机构医用氧的运输和使用中存在较多的问题。这些问题可导致例如气管爆炸等致命事故的发生和假冒药品的使用。究其原因,这是由于缺乏相关的标准,管理和实践经验造成的。因此作者建议通过学习国外,如法国的先进经验和规章制度,来解决这些问题。 | 林硕 Hélène van den Brink Eric Fouassier Alejandro Berardi | 2010 | Journal of Chinese Pharmaceutical Sciences2010，19，3： | 1 |
| 18 | Cloning and sequencing of the genes involved in glyphosate utilization by pseudomonas pseudomoallei 显示文摘 | ALEJANDRO P V GILDAL M LUIS H E | 1995 | Applied and Environmental Microbiology1995，61，2： | 1 |
| 19 | Cloning and sequencing of the genes involved in glyphosate utilization by pseudomonas pseudomallei显示文摘 | Alejandro P V Gildal M Luis H E | 1995 | Applied and Environmental Microbiology1995，61，2： | 1 |
| 20 | Richards equation model of a rain garden 显示文摘 | Alejandro R Dussaillant Chin H Wu Kenneth W Potter | 2004 | J Hydrol Eng ASC E2004，9，3： | 1 |
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