|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hydrogen sutfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocvanate induced apoptosis显示文摘AIM: Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of H2S are reported to range between 0.2-3.4 mmol/L in the GI tract of mice and humans. Considering such high levels we speculate that, at non-toxic concentrations, H2S may interact with chemical agents and alter the response of colonic epithelium cells to such compounds. The GI tract is a major site for the absorption of phytochemical constituents such as isothiocyanates, flavonoids, and carotenoids, with each group having a role in the prevention of human diseases such as colon cancer. The chemopreventative properties of the phytochemical agent β-phenyethyl isothiocyanate (PEITC) are well recognized. However, little is currently known about the physiological or biochemical factors present in the GI tract that may influence the biological properties of ITCs. The current study was undertaken to determine the effects of H2S on PEITC mediated apoptosis in colon cancer cells.METHODS: Induction of apoptosis by PEITC in human colon cancer HCT116 cells was assessed using classic apoptotic markers namely SubG1 population analysis,caspase-3 like activity and nuclear fragmentation and condensation coupled with the MTT (3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrasodium bromide) viability assay and LDH leakage.RESULTS: PEITC significantly induced apoptosis in HGT116cells as assessed by SubG1 population formation, nuclear condensation, LDH leakage and caspase-3 activity after 24 h, these data being significant from control groups (P<0.01). In contrast, co-treatment of cells with physiological concentrations of H2S (0.1-1 mmol/L) prevented PEITC mediated apoptosis as assessed using the parameters described.CONCLUSION: PEITC effectively induced cell death in the human adenocarcinoma cell line HCT116 in vitro through classic apoptotic mechanisms. However, in the presence of H2S, apoptosis was abolished. These data suggest that H2S may play a significant role in the response of colonic epithelial cells to beneficial as well as toxic agents present within the GI tract. | Peter Rose Philip K Moore Shen Han Ming Ong Choon Nam Jeffrey S Armstrong Matt Whiteman | 2005 | World Journal of Gastroenterology2005，11，26： | 13 |
| 2 | Dredging effects on selected nutrient concentrations and ecoenzymatic activity in two drainage ditch sediments in the lower Mississippi River Valley显示文摘Agricultural drainage ditches are conduits between production acreage and receiving aquatic systems.Often overlooked for their mitigation capabilities,agricultural drainage ditches provide an important role for nutrient transformation via microbial metabolism.Variations in ecoenzyme activities have been used to elucidate microbial metabolism and resource demand of microbial communities to better understand the relationship between altered nutrient ratios and microbial activity in aquatic ecosystems.Two agricultural drainage ditches,one in the northeast portion of the Arkansas Delta and the other in the lower Mississippi Delta,were monitored for a year.Sediment samples were collected prior to each ditch being dredged(cleaned),and subsequent post-dredging samples occurred as soon as access was available.Seasonal samples were then collected throughout a year to examine effects of dredging on selected nutrient concentrations and ecoenzymatic activity recovery in drainage ditch sediments.Phosphorus concentrations in sediments after dredging decreased 33–66%,depending on ditch and phosphorus extraction methodology.Additionally,ecoenzymatic activity was significantly decreased in most sediment samples after dredging.Fluorescein diacetate hydrolysis activity,an estimate of total microbial activity,decreased 56–67%after dredging in one of the two ditches.Many sample sites also had significant phosphorus and ecoenzymatic activity differences between the post-dredge samples and the year-long follow-up samples.Results indicate microbial metabolism in dredged drainage ditches may take up to a year or more to recover to pre-dredged levels.Likewise,while sediment nutrient concentrations may be decreased through dredging and removal,runoff and erosion events over time tend to quickly replenish nutrient concentrations in replaced sediments.Understanding nutrient dynamics and microbial metabolism within agricultural drainage ditches is a crucial step toward addressing issues of nutrient enrichment in aquatic receiving systems,especially those contributing to the Gulf of Mexico. | Matt Moore Martin A.Locke Michael Jenkins Robert W.Steinriede Daniel S.McChesney | 2017 | International Soil and Water Conservation Research2017，5，3： | 1 |
| 3 | The effects of capsaicin and capsiate on energy balance:critical review and meta-analyses of studies in humans显示文摘 | LUDY MJ MOORE GE MATTES RD | 2012 | Chem Senses2012，37，2： | 1 |
| 4 | The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans显示文摘 | Ludy M J Moore G E Mattes R D | 2012 | Chem Senses2012，37，2： | 1 |
| 5 | The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans显示文摘 | LUDY M J MOORE G E MATTES R D | 2012 | Chemical Senses2012，37，2： | 1 |
| 6 | Measurements necessary for assessing the net ecosystem carbon budget of croplands显示文摘 | Pete Smith Gary Lanigan Werner L. Kutsch Nina Buchmann Werner Eugster Marc Aubinet Eric Ceschia Pierre Béziat Jagadeesh B. Yeluripati Bruce Osborne Eddy J. Moors Aurore Brut Martin Wattenbach Matt Saunders Mike Jones | 2010 | Agriculture Ecosystems and Environment2010，，3： | 1 |
| 7 | 奥巴马出乎意料获2009年诺贝尔和平奖(英文)显示文摘The announcement drew gasps of surprise1 and cries too much, too soon. Yet President Barack Obama won the 2009 Nobel Peace Prize | Karl Ritter Matt Moore 孙育红 | 2009 | 大学英语2009，，12： | 0 |
| 8 | 美国人获诺贝尔物理学奖显示文摘 | Karl Ritter Matt Moore 贾庆文(编译) | 2006 | 大学英语2006，，11： | 0 |
| 9 | 2008诺贝尔医学奖花落三家显示文摘诺贝尔奖是世界科学的最高奖项,授予世界各国在医药领域对人类作出重大贡献的学者。2008年诺贝尔医学奖日前揭晓,三名欧洲科学家因病毒研究而获得了该项殊荣。 | Karl Ritter Matt Moore 栾雪梅 | 2008 | 中国处方药2008，7，9： | 0 |
| 10 | Reservoir construction from the Newberry Volcano EGS Demonstration显示文摘The Newberry Volcano EGS Demonstration in central Oregon tests recent technological advances designed to reduce the cost of power generated by EGS in a hot,dry well(NWG 55-29) drilled in 2008. An EGS reservoir was created by injecting large volumes of cold water,causing existing fractures to slip in shear(known as hydroshearing) generating the seismic waves that can be used to map fracture location and size. At the Newberry Demonstration the final injectivity ranged between 1.4 and 1.7 L/s/MPa a ~6x improvement over the initial injectivity of the well. The injectivity improvement and seismic analysis indicate that previously impermeable fractures were enhanced during the NWG 55-29 stimulation. | Trenton T Cladouhos Susan Petty Yini Nordin Michael Moore Kyla Grasso Matt Uddenberg Michael W Swyer | 2014 | Journal of Groundwater Science and Engineering2014，2，3： | 0 |
| 11 | 哈马斯领导人兰提西在以色列袭击中丧生显示文摘巴勒斯坦伊斯兰抵抗运动(哈马斯)领导人兰提西曾对记者说:'被杀害或得癌症都是死。被‘阿帕奇’(直升机)炸死或心脏停跳也是死。我宁愿被‘阿帕奇’炸死。'今年4月17日,他果真被以色列'阿帕奇'直升机发射的导弹炸死,这时离3月22日哈马斯创始人和精神领袖亚辛被以色列暗杀还不到1个月。以色列为何如此有恃无恐,大开杀戒呢?在此,我们摘译了路透社一篇电讯稿和《华盛顿邮报》一篇文章,对兰提西这个人物做个简要介绍并配以分析家们有关的分析和评论。 | Matt Spetalnick Molly Moore John Ward Anderson 陈树培 | 2004 | 英语文摘2004，0，6： | 0 |
| 12 | 欧元十周年,承诺在实现显示文摘1O年前,欧洲用一种共同货币启动了它的重大实验,并且目睹了其因急剧贬值以至需要各国央行紧急援助的一幕。 | Matt Moore George Frey 彭宏权 | 2009 | 英语文摘2009，，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员