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| 1 | Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death显示文摘 | Mathieu Vinken Elke Decrock Elke Vuyst Marijke Bock Roosmarijn E. Vandenbroucke Bruno G. Geest Joseph Demeester Niek N. Sanders Tamara Vanhaecke Luc Leybaert Vera Rogiers | 2010 | Cellular and Molecular Life Sciences2010，，6： | 2 |
| 2 | Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity显示文摘 | Mathieu Vinken Tatyana Doktorova Elke Decrock Luc Leybaert Tamara Vanhaecke Vera Rogiers | 2009 | Critical Reviews in Biochemistry and Molecular Biology2009，，4： | 1 |
| 3 | Modifications in Connexin Expression in Liver Development and Cancer显示文摘 | Mathieu Vinken Joery de Kock André G. Oliveira Gustavo B. Menezes Bruno Cogliati Maria Lú cia Zaidan Dagli Tamara Vanhaecke Vera Rogiers | 2012 | Cell Communication and Adhesion . 2012 (3-4)2012，，： | 1 |
| 4 | Connexins and their channels in cell growth and cell death 显示文摘 | Mathieu Vinken Tamara Vanhaecke Peggy Papeleu | 2005 | Cell Signal2005，18，5： | 1 |
| 5 | The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation显示文摘 | Kuo Du C. David Williams Mitchell R. McGill Yuchao Xie Anwar Farhood Mathieu Vinken Hartmut Jaeschke | 2013 | Toxicology and Applied Pharmacology2013，，3： | 1 |
| 6 | Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity显示文摘 | Mathieu Vinken Tatyana Doktorova Elke Decrock Luc Leybaert Tamara Vanhaecke Vera Rogiers | 2009 | Critical Reviews in Biochemistry and Molecular Biology2009，，4： | 1 |
| 7 | Connexins and their channels in cell growth and cell death显示文摘 | Mathieu Vinken Tamara Vanhaecke Peggy Papeleu Sarah Snykers Tom Henkens Vera Rogiers | 2005 | Cellular Signalling2005，，5： | 1 |
| 8 | Comparison of genotoxicant-modified transcriptomic responses in conventional and epigenetically stabilized primary rat hepatocytes with in vivo rat liver data显示文摘 | Tatyana Y. Doktorova Heidrun Ellinger-Ziegelbauer Mathieu Vinken Tamara Vanhaecke Joost Delft Jos Kleinjans Hans-Juergen Ahr Vera Rogiers | 2012 | Archives of Toxicology2012，，11： | 1 |
| 9 | Connexin-based signaling and drug-induced hepatotoxicity显示文摘Being critical mediators of liver homeostasis,connexins and their channels are frequently involved in liver toxicity.In the current paper,specific attention is paid to actions of hepatotoxic drugs on these communicative structures.In a first part,an overview is provided on the structural,regulatory and functional properties of connexin-based channels in the liver.In the second part,documented effects of acetaminophen,hypolipidemic drugs,phenobarbital and methapyriline on connexin signaling are discussed.Furthermore,the relevance of this subject for the fields of clinical and in vitro toxicology is demonstrated.Relevance for patients:The role of connexin signaling in drug-induced hepatotoxicity may be of high clinical relevance,as it offers perspectives for the therapeutic treatment of such insults by interfering with connexin channel opening. | Michael Maes Mathieu Vinken | 2017 | Journal of Clinical & Translational Research2017，3，1： | 0 |
| 10 | Role of connexin-related signalling in hepatic homeostasis and its relevance for liver-based in vitro modelling显示文摘Direct intercellular communication mediated by gap junctions constitutes a major regulatory platform in the control of hepatic homeostasis.Hepatocellular gap junctions are composed of two hemichannels of adjacent cells which are built up by connexin proteins,in casu Cx32.Mathieu Vinken,Pofessor at the Department of Toxicology of the Free University BrusselsBelgium,was one of the first investigators to demonstrate that hepatic connexin expression is controlled by epigenetic mechanisms.In particular,he found that inhibitors of histone deacetylase enzymes enhance Cx32 production and gap junction activity in cultures of primary hepatocytes,a finding that is of importance for liver-based in vitro modelling.Professor Dr.Mathieu Vinken's recent work is focussed on the elucidation of the role of connexin proteins and their channels in the hepatocyte life cycle.Specific attention is paid to apoptosis in this context,whereby it has been found that Cx32 hemichannels control the termination of induced cell death in cultures of primary hepatocytes. Overall,Professor Dr.Mathieu Vinken's research can be considered as an important contribution to the field of hepatic connexin physiology. | Mathieu Vinken | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，5： | 0 |
| 11 | Emerging roles of connexin hemichannels in gastrointestinal and liver pathophysiology显示文摘Connexin hemichannels have long been considered asmere structural precursors for gap junctions.In the last decade,it has become clear that they also act as individual channels,connecting the intracellular compartment and the extracellular environment.Impairement of connexin hemichannel functionality may result in disturbance of homeostasis,as exemplified in the current paper for the intestine and the liver.Research in this field still has a number of shortcomings,of which some are also discussed here. | Mathieu Vinken Tamara Vanhaecke Vera Rogiers | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，4： | 0 |
| 12 | Systematic comparison of experimental and human obstructive cholestasis reveals conservation of canonical pathway activation and biomarkers relevant for cholestatic liver disease显示文摘Cholelithiasis-induced cholestasis is one of the most common causes of hospitalization due to gastrointestinal disease,yet considerable knowledge gaps exist in the pathogenesis of this disease.This can partially be explained by inadequate characterization of experimental cholestasis models.Here,we compared the transcriptional profile of commonly used mouse models for obstructive cholestasis and benchmarked them to human disease to identify the model(s)best suited for cholelithiasis-induced cholestasis research and to uncover conserved mechanisms involved in human and murine cholestasis. | Eva Gijbels Kevin De Muynck Bart Vanderborght Tim Meese Filip Van Nieuwerburgh Aude Vanlander Frederik Berrevoet Bart Hendrikx Anne Hoorens Hans Van Vlierberghe Mathieu Vinken Lindsey Devisscher | 2023 | Genes & Diseases2023，10，1： | 0 |
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