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| 1 | interrelationships between ghrelin, insulin and glucose homeostasis: physiological relevance显示文摘Ghrelin is a 28 amino acid peptide mainly derived from the oxyntic gland of the stomach. Both acylated(AG) and unacylated(UAG) forms of ghrelin are found in the circulation. Initially, AG was considered as the only bioactive form of ghrelin. However, recent advances indicate that both AG and UAG exert distinct and common effects in organisms. Soon after its discovery, ghrelin was shown to promote appetite and adiposity in animal and human models. In response to these anabolic effects, an impressive number of elements have suggested the influence of ghrelin on the regulation of metabolic functions and the development of obesityrelated disorders. However, due to the complexity ofits biochemical nature and the physiological processes it governs, some of the effects of ghrelin are still debated in the literature. Evidence suggests that ghrelin influences glucose homeostasis through the modulation of insulin secretion and insulin receptor signaling. On the other hand, insulin was also shown to influence circulating levels of ghrelin. Here, we review the relationship between ghrelin and insulin and we describe the impact of this interaction on the modulation of glucose homeostasis. | FranCois Chabot Alexandre Caron Mathieu Laplante David H St-Pierre | 2014 | World Journal of Diabetes2014，5，3： | 9 |
| 2 | INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis(NASH).METHODS The effects of INT-767 on histological features of NASH were assessed in two studies using Lep^(ob/ob)(ob/ob) NASH mice fed the AMLN diet(high fat with transfat, cholesterol and fructose). In a proof-of-conceptstudy, Lep^(ob/ob)(ob/ob) NASH mice were first dosed with INT-767(3 or 10 mg/kg for 8 wk). A second ob/ob NASH study compared INT-767(3 and 10 mg/kg) to obeticholic acid(OCA)(10 or 30 mg/kg; 16 wk). Primary histological endpoints included qualitative and quantitative assessments of NASH. Other metabolic and plasma endpoints were also assessed. A comparative assessment of INT-767 and OCA effects on drug distribution and hepatic gene expression was performed in C57 Bl/6 mice on standard chow. C57 Bl/6 mice were orally dosed with INT-767 or OCA(1-30 mg/kg) for 2 wk, and expression levels of candidate genes were assessed by RNA sequencing and tissue drug levels were measured by liquid chromatography tandem-mass spectrometry.RESULTS INT-767 dose-dependently(3 and 10 mg/kg, PO, QD, 8 wk) improved qualitative morphometric scores on steatohepatitis severity, inflammatory infiltrates and fibrosis stage. Quantitative morphometric analyses revealed that INT-767 reduced parenchymal collagen area, collagen fiber density, inflammation(assessed by Galectin-3 immunohistochemistry) and hepatocyte lipid droplet area following INT-767 treatment. In a comparative study(16 wk), the FXR agonists OCA(10 and 30 mg/kg) and INT-767(3 and 10 mg/kg) both improved NASH histopathology, with INT-767 exerting greater therapeutic potency and efficacy than OCA. Mechanistic studies suggest that both drugs accumulate similarly within the liver and ileum, however, the effects of INT-767 may be driven by enhanced hepatic, but not ileal, FXR function. CONCLUSION These findings confirm the potential utility of FXR and dual FXR/TGR5 activation as disease intervention strategies in NASH. | Jonathan D Roth Michael Feigh Sanne S Veidal Louise KD Fensholdt Kristoffer T Rigbolt Henrik H Hansen Li C Chen Mathieu Petitjean Weslyn Friley Niels Vrang Jacob Jelsing Mark Young | 2018 | World Journal of Gastroenterology2018，24，2： | 7 |
| 3 | Characterization of the caprine stearoyl-CoA desaturase gene and its mRNA showing an unusually long 3′-UTR sequence arising from a single exon显示文摘 | Laurence Bernard Christine Leroux Hélène Hayes Mathieu Gautier Yves Chilliard Patrice Martin | 2001 | Gene2001，，1： | 2 |
| 4 | In Situ Dynamics of Microbial Communities during Decomposition of Wheat,Rape,and Alfalfa Residues显示文摘 | Pascault N Cécillon L Mathieu O Hénault C Sarr A Lév(e)que J Fatty P Ranjard L Maron PA | | 0，，04： | 1 |
| 5 | Radiation dose reduction for CT lung cancer screening using ASIR and MBIR: a phantom study显示文摘 | Mathieu K B Ai H Fox P S | 2014 | J Appl Clin Med Phys2014，15，2： | 1 |
| 6 | A better response in ex- ercise capacity after pulmonary rehabilitation in more severe COPD patients显示文摘 | Wytske A Mathieu H Nick H | 2012 | Respiratory Medicine2012，106，5： | 1 |
| 7 | Long term plasticity of ipsilesional vestibular nucleus neurons after unilateral labyrinthectomy显示文摘 | Mathieu B Mohammed H Erwin I | 2003 | J Neurophysiol2003，90，： | 1 |
| 8 | Intercomparison of surface analysis of thin aluminum oxide films显示文摘 | OLEFJORD I MATHIEU H J MARCUS P | 1990 | Surface and Interface Analysis1990，15，： | 1 |
| 9 | Oral Contraceptive use and focal nodular hy-Perplasia of the liver显示文摘 | Mathieu D Kobeiter H Maison P | 2000 | Gastroenterology2000，118，： | 1 |
| 10 | Reflectance and trans- mittance model for recto-verso halltone prints显示文摘 | Mathieu H Hersch R D | 2006 | J Opt Soc Am2006，23，10： | 1 |
| 11 | Trigeminal neuralgia:outcomes after gamma knife radiosurgery显示文摘 | Knafo H Kenny B Mathieu D | 2009 | Can J Neurol Sci2009，36，1： | 1 |
| 12 | Part-load operation ofcombined cycle plant with and without supplementary firing显示文摘 | DECHAMPS P J PIRARD N MATHIEU P H | 1995 | Journal of Engineering for Gas Turbines and Power1995，117，3： | 1 |
| 13 | Investi- gations of the reasons for fungal durability of heat-treated beech wood 显示文摘 | MOHAMMED H MATHIEU P ANDRE Z | 2006 | Polymer Degradation and Stability2006，91，2： | 1 |
| 14 | A better response in exercise capacity after pulmonary rehabilitation in more severe COPD patients显示文摘 | Wytske A Mathieu H Nick H | 2012 | Respiratory Medicine2012，106，5： | 1 |
| 15 | Leaf mitochondria modulate whole cell redox homeostasis, set antioxidant capacity, and determine stress resistance through altered signaling and diurnal regulation显示文摘 | DUTILLEUL C GARMIER M NOCTOR G MATHIEU C CHETRIT P FOYER C H DE PAEPE R | 2003 | Plant Cell2003，15，： | 1 |
| 16 | An efficient computa- tional method for global sensitivity analysis and its application to tree growth modeling 显示文摘 | Wu Q L Coumede P H Mathieu A | 2012 | Reliabihty Engineering and Sys- tem Safety2012，107，： | 1 |
| 17 | Routes to functional Vesicle membrances without proteins显示文摘 | FUHRHOP J H MATHIEU J | 1984 | Angew Chem Int Ed Engl1984，23，： | 1 |
| 18 | Tolerance to cardiac allografts via local and systemic mechanisms after adenovirus-mediated CTLA4 Ig expression 显示文摘 | Mathieu P Coathalem H | 2000 | J Immunol2000，64，10： | 1 |
| 19 | Oral contraceptive intake in women focal nodular hyperplasia of the liver显示文摘 | Mathieu D Kobeiter H Cherqui D | 1998 | Lancet1998，352，9141： | 1 |
| 20 | Tolerance to cardiac allografts via local and systemic mechanisms after adenovirus-mediated CTLA41g expression显示文摘 | Guillol C Mathieu P Coathalern H | 2000 | J Immunol2000，164，10： | 1 |
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