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| 1 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 2 | DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection显示文摘 | Oertli Mathias Sundquist Malin Hitzler Iris Engler Daniela B Arnold Isabelle C Reuter Sebastian Maxeiner Joachim Hansson Malin Taube Christian Quiding-J?rbrink Marianne Müller Anne | 2012 | EN2012，，3： | 5 |
| 3 | A framework infrageneric classification of Carex (Cyperaceae) and its organizing principles显示文摘Phylogenetic studies of Carex L.(Cyperaceae)have consistently demonstrated that most subgenera and sections are para-or polyphyletic.Yet,taxonomists continue to use subgenera and sections in Carex classification.Why?The Global Carex Group(GCG)here takes the position that the historical and continued use of subgenera and sections serves to(i)organize our understanding of lineages in Carex,(ii)create an identification mechanism to break the~2000 species of Carex into manageable groups and stimulate its study,and(iii)provide a framework to recognize morphologically diagnosable lineages within Carex.Unfortunately,the current understanding of phylogenetic relationships in Carex is not yet sufficient for a global reclassification of the genus within a Linnean infrageneric(sectional)framework.Rather than leaving Carex classification in its current state,which is misleading and confusing,we here take the intermediate steps of implementing the recently revised subgeneric classification and using a combination of informally named clades and formally named sections to reflect the current state of our knowledge.This hybrid classification framework is presented in an order corresponding to a linear arrangement of the clades on a ladderized phylogeny,largely based on the recent phylogenies published by the GCG.It organizes Carex into six subgenera,which are,in turn,subdivided into 62 formally named Linnean sections plus 49 informal groups.This framework will serve as a roadmap for research on Carex phylogeny,enabling further development of a complete reclassification by presenting relevant morphological and geographical information on clades where possible and standardizing the use of formal sectional names. | Eric H.Roalson Pedro Jiménez-Mejías Andrew L.Hipp Carmen Benítez-Benítez Leo P.Bruederle Kyong-Sook Chung Marcial Escudero Bruce A.Ford Kerry Ford Sebastian Gebauer Berit Gehrke Marlene Hahn Muhammad Qasim Hayat Mathias H.Hoffmann Xiao-Feng Jin Sangtae Kim Isabel Larridon Étienne Léveillé-Bourret Yi-Fei Lu Modesto Luceño Enrique Maguilla Jose IgnacioMárquez-Corro Santiago Martín-Bravo Tomomi Masaki Mónica Míguez Robert F.C.Naczi Anton A.Reznicek Daniel Spalink Julian R.Starr Uzma Tamara Villaverde Marcia J.Waterway Karen L.Wilson and Shu-Ren Zhang | 2021 | Journal of Systematics and Evolution2021，59，4： | 3 |
| 4 | Six-minute walking test performance is associated with survival in cirrhotic patients显示文摘BACKGROUND Patients with cirrhosis are at risk of cirrhotic cardiomyopathy,with resulting cardiac dysfunction and exercise limitations.Six minute walking test(6MWT)assesses functional status and predicts morbidity and mortality in cardiopulmonary diseases.AIM To determine if it associates with mortality by analyzing 6MWT performance in patients with liver cirrhosis.METHODS A cohort of 106 cirrhotic patients was evaluated in the outpatient setting with echocardiogram and 6MWT and follow up for one year to document hepatic decompensation and mortality.The distance in meters was recorded at the end of 6 min(6MWD).RESULTS This cohort had a mean age of 51 years and 56%male;patients were staged as Child A in 21.7%,B 66%and C 12.3%.Walk distance inversely correlated with Child scores,and was significantly reduced as Child stages progresses.Patients who died(10.4%)showed shorter mean 6MWD(P=0.006).Low 6MWD was an independent predictor of mortality(P=0.01).CONCLUSION 6MWT is a noninvasive inexpensive test whose result is related to Child scores and mortality.It is useful to identify patients with liver cirrhosis at high risk of mortality for closer monitoring and potential early intervention. | Carolina Frade M G Pimentel Ana Cristina de Castro Amaral Adriano Miziara Gonzalez Michelle Lai Danielde Oliveira Mota Maria Lucia Gomes Ferraz Wilson Mathias Junior Mario Kondo | 2021 | World Journal of Hepatology2021，13，11： | 2 |
| 5 | Innate immune recognition on the intestinal mucosa显示文摘 | Michael Lotz Sandrine Ménard Mathias Hornef | 2007 | International Journal of Medical Microbiology2007，，5： | 2 |
| 6 | Voxel-based analyses of magnetization transfer imaging of the brain in hepatic encephalopathy显示文摘AIM: To evaluate the spatial distribution of cerebral abnormalities in cirrhotic subjects with and without hepatic encephalopathy (HE) found with magnetization transfer imaging (MTI).METHODS: Nineteen cirrhotic patients graded from neurologically normal to HE grade 2 and 18 healthy control subjects underwent magnetic resonance imaging. They gave institutional-review-board-approved written consent. Magnetization transfer ratio (MTR) maps were generated from MTI. We tested for significant differences compared to the control group using statistical non-parametric mapping (SnPM) for a voxelbased evaluation.RESULTS: The MTR of grey and white matter was lower in subjects with more severe HE. Changes were found in patients with cirrhosis without neurological defi cits in the basal ganglia and bilateral white matter. The loss in magnetization transfer increased in severity and spatial extent in patients with overt HE. Patients with HE grade 2 showed an MTR decrease in white and grey matter: the maximum loss of magnetization transfer effect was located in the basal ganglia [SnPM (pseudo-)t = 17.98, P = 0.0001].CONCLUSION: The distribution of MTR changes in HE points to an early involvement of basal ganglia and white matter in HE. | Falk R Miese Hans-Jrg Wittsack Gerald Kircheis Arne Holstein Christian Mathys Ulrich Mdder Mathias Cohnen | 2009 | World Journal of Gastroenterology2009，15，41： | 2 |
| 7 | On-target temporal characterization of optical pulses at relativistic intensity显示文摘High-field experiments are very sensitive to the exact value of the peak intensity of an optical pulse due to the nonlinearity of the underlying processes.Therefore,precise knowledge of the pulse intensity,which is mainly limited by the accuracy of the temporal characterization,is a key prerequisite for the correct interpretation of experimental data.While the detection of energy and spatial profile is well established,the unambiguous temporal characterization of intense optical pulses,another important parameter required for intensity evaluation,remains a challenge,especially at relativistic intensities and a few-cycle pulse duration.Here,we report on the progress in the temporal characterization of intense laser pulses and present the relativistic surface second harmonic generation dispersion scan(RSSHG-D-scan)—a new approach allowing direct on-target temporal characterization of high-energy,few-cycle optical pulses at relativistic intensity. | Vyacheslav E.Leshchenko Alexander Kessel Olga Jahn Mathias Kruger Andreas Münzer Sergei ATrushin Laszlo Veisz Zsuzsanna Major Stefan Karsch | 2019 | Light(Science & Applications)2019，8，1： | 2 |
| 8 | Coronary blood flow reserve response to left anterior descending coronary artery stenting and its value in predicting coronary restenosis显示文摘 | Tsutsui J M Mathias W Jr Frimm C C | 2003 | J Am Soc Echocardiogr2003，16，5： | 2 |
| 9 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 10 | Surface tension of electrolytes:Specific ion effects explained by dispersion forces显示文摘 | Mathias Bostrom David R M Williams Barry W Ninham | 2001 | Langmuir2001，17，： | 1 |
| 11 | The avian cecum: a review显示文摘 | CLENCH M H MATHIAS J R | 1995 | Wilson Bull1995，107，1： | 1 |
| 12 | Hydrogen bonds显示文摘 | WHITESIDES G M MATHIAS J P SETO C T | 1991 | Science1991，254，5036： | 1 |
| 13 | Synthesis and characterization of antibacterial and temperature responsive methacrylamide polymers显示文摘 | B Dizman M O Elasri L J Mathias | 2006 | Macromolecules2006，39，： | 1 |
| 14 | Aprotinin improves pulmonary function during reperfusion in an isolated lung model显示文摘 | Mathias M A Tribble C G Dietz J F | 2000 | Ann Thorac Surg2000，70，5： | 1 |
| 15 | Aberrant aggregation behavior in cationic gemini surfactants investigated by surface tension, interfacial tension, and fluorescence methods显示文摘 | Rosen M J Mathias J H Davenport L | 1999 | Langmuir1999，15，21： | 1 |
| 16 | Molecular self-assembly and nanochemistry: a chemical strategy for the synthesis of nanostructures显示文摘 | WHITESIDES G M MATHIAS J P SETO C T | 1991 | Science1991，254，5036： | 1 |
| 17 | Molecular self-assembly through hydrogen bonding: aggregation of five molecules to form a discrete supramolecular structure 显示文摘 | SETO C T MATHIAS J P WHITESIDE G M | 1993 | J Am Chem Soc1993，115，： | 1 |
| 18 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
| 19 | Left Atrial Function After Ablation for Paroxysmal Atrial Fibrillation显示文摘 | Ana Clara Tude Rodrigues Mauricio I. Scannavacca Márcia Azevedo Caldas Viviane Tiemi Hotta Cristiano Pisani Eduardo A. Sosa Wilson Mathias | 2009 | The American Journal of Cardiology2009，，3： | 1 |
| 20 | Novel photochemical surface functionalization of polysulfone ultrafiltration membranes for covalent immobilization of biomolecules 显示文摘 | Marco R Uwe M | 1996 | J Membr Sci1996，121，： | 1 |
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