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| 1 | MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines显示文摘AIM:To investigate expression of microRNA(miRNA)and potential targets in chemotherapy resistant esoph-ageal cancer cell lines.METHODS:An in-vitro model of acquired chemotherapy resistance in esophageal adeno-(EAC)and squamous cell carcinoma(ESCC)cells was used,and microRNA expression profiles for cisplatin or 5-fluorouracil(5-FU)resistant variants vs chemotherapy sensitive controls were compared using microarray and quantitative real-time polymerase chain reaction(PCR).The expression of chemotherapy-relevant genes potentially targeted by the dysregulated microRNAs in the chemotherapy resistant variants was also evaluated.RESULTS:Chemotherapy resistant sublines were found to have specific miRNA signatures,and these miRNA signatures were different for the cisplatin vs 5-FU resistant cells from the same tumor cell line,and also for EAC vs ESCC cells with resistance to the same specific chemotherapy agent.Amongst others,miR-27b-3p,miR-193b-3p,miR-192-5p,miR-378 a-3p,miR-125a-5p and miR-18a-3p were dysregulated,consistent with negative posttranscriptional control of KRAS,TYMS,ABCC3,CBL-B and ERBB2 expression via these miRNAs.CONCLUSION:The current study supports the hypothesis that microRNA expression has an impact on chemotherapy resistance in esophageal cancer. | Richard Hummel Corina Sie David I Watson Tingting Wang Alfiya Ansar Michael Z Michael Mark Van der Hoek Joerg Haier Damian J Hussey | 2014 | World Journal of Gastroenterology2014，20，40： | 8 |
| 2 | Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada显示文摘AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990.These data were integrated with prescription drug,medical visit,hospitalization and mortality data.HBV cases were classified as acute or chronic according to provincial guidelines.We compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative group.RESULTS46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic infections.Problematic alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative individuals.In multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug use.The odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic HBV.Persons with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV infection.These odds increased with increasing socioeconomic deprivation.CONCLUSION Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,prevention,care and treatment programs. | Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua | 2018 | World Journal of Gastroenterology2018，24，11： | 3 |
| 3 | The parameters and molecular events associated with radiation-induced lung toxicity显示文摘 | Vujaskovic Z Marks LB Anscher MS | 2000 | Semin Radiat Oncol2000，10，4： | 2 |
| 4 | Sun,vrlnd&light: arehltee- ture design strategies John显示文摘 | Bmcn G Z DaKay Mark Barbhaya D | 2000 | Wiley2000，2000，： | 1 |
| 5 | Network design approach for hub ports-shipping companies competition and coop- eration显示文摘 | Nasrin A Reza Z F Mark G | 2013 | Transportation Research Part A2013，48，2： | 1 |
| 6 | Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation显示文摘 | Mark RJ Pang Z Geddes JW | 1997 | J Neuroscij1997，17，3： | 1 |
| 7 | Real-time estimation of fundamental frequency and harmonics for active shunt power filters in aircraft electrical systems显示文摘 | ELISABETTA L PERICLE Z MARK S | 2009 | IEEE Transactions on Industrial Electronics2009，56，8： | 1 |
| 8 | Apoptotic and autophagic cell death induced by histone deacetylase inhibitors显示文摘 | Shao Y Gao Z Marks PA | 2004 | Proc Natl Acad Sci USA2004，101，18： | 1 |
| 9 | The future of wind forecasting and utility operations显示文摘 | Mark A Lawrence J Robert Z | 2005 | IEEE Power Energy Magzine2005，6，3： | 1 |
| 10 | Laboratory studies of wind stress over surface waves显示文摘 | METE B U Z MARK A DONELAN | 2002 | Boundary Layer Meteorology2002，102，2： | 1 |
| 11 | The physical parameters and molecular events associated with radiation-induced lung toxicity显示文摘 | Vujaskovic Z Marks LB Anscher MS | | 0，，04： | 1 |
| 12 | Decomposition of PCBs and other polycholorinated aromatics in soil using microwave enery显示文摘 | RUDOLPH A A HUANG B Z MARK D | 1998 | Chemosphere1998，37，8： | 1 |
| 13 | Morbidity and mortality of cytoreductive surgery and intraperitoneal chemotherapy显示文摘 | Jusus Z Joun V Mark AS | 1993 | Surgery1993，113，6： | 1 |
| 14 | Injection of human primary effusion lymphoma cells or associated macrophages into severe combined immunodeficient mice causes murine lymphomas 显示文摘 | Elisabeth Z Nancy W A Mark D W | 2002 | Cancer Res2002，62，： | 1 |
| 15 | Empirical relation between rock strength and physical properties in sedimentary rocks显示文摘 | CHANG C D MARK D Z ABBAS K | 2006 | Journal of Petroleum Science and Engineering2006，51，22： | 1 |
| 16 | Photoscattering effect in supercontinuum - generating photonic crystal fiber显示文摘 | TU H MARKS D L JIANG Z | 2008 | Appl Phys Lett2008，92，06： | 1 |
| 17 | Ultra_fine structure of the hydroxyapa- tite amorphous phase in noninfectious phosphate renal calculi 显示文摘 | Mark~ta Z Otakar S Felix G | 2012 | Urology2012，79，4： | 1 |
| 18 | Validation of a mus- culo-skeletal model of the mandible and its application to mandib- ular distraction osteogenesis显示文摘 | Mark D Z Dalstra M Rasmussen J | 2007 | Journal of Biomechanics2007，40，6： | 1 |
| 19 | Expression of early lung cancer detedtion marker:hnRNP-A2/B1 and its relation to microsatellite alteration in non-small cell lung cancer显示文摘 | Jun Z Liang N Mark Wloch | 2000 | Lung Cancer2000，34，： | 1 |
| 20 | Analysis of musculoskeletal systems in the AnyBody modeling system显示文摘 | Michael D John R Mark D Z | 2006 | Simulation Model- ling Practice and Theory2006，14，8： | 1 |
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