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| 1 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 2 | 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines显示文摘 | Neil J. Stone Jennifer G. Robinson Alice H. Lichtenstein C. Noel Bairey Merz Conrad B. Blum Robert H. Eckel Anne C. Goldberg David Gordon Daniel Levy Donald M. Lloyd-Jones Patrick McBride J. Sanford Schwartz Susan T. Shero Sidney C. Smith Karol Watson Pet | 2014 | Circulation (_suppl_ Suppl)2014，，25： | 2 |
| 3 | Higher infliximab and adalimumab trough levels are associated with fistula healing in patients with fistulising perianal Crohn’s disease显示文摘BACKGROUND Tumor necrosis factor-alpha inhibitors,including infliximab and adalimumab,are effective medical treatments for perianal fistulising Crohn’s disease(CD),but not all patients achieve fistula healing.AIM To determine the correlation between perianal fistula healing and closure with infliximab and adalimumab trough levels.METHODS In this multicentre retrospective study conducted across four tertiary inflammatory bowel disease centres in Australia,we identified CD patients with perianal fistulae on maintenance infliximab or adalimumab who had a trough level within twelve weeks of clinical assessment.Data collected included demographics,serum infliximab and adalimumab trough levels(mg/L)within 12 wk before or after their most recent clinical assessment and concomitant medical or surgical therapy.The primary outcome was fistula healing,defined as cessation in fistula drainage.The secondary outcome was fistula closure,defined as healing and closure of all external fistula openings.Differences between patients who did or did not achieve fistula healing were compared using the chi-square test,t test or Mann-Whitney U test.RESULTS One hundred and fourteen patients(66 infliximab,48 adalimumab)were included.Forty-eight(72.7%)patients on maintenance infliximab achieved fistula healing and 18(27.3%)achieved fistula closure.Thirty-seven(77%)patients on maintenance adalimumab achieved fistula healing and 17(35.4%)achieved fistula closure.Patients who achieved fistula healing had significantly higher infliximab and adalimumab trough levels than patients who did not[infliximab:6.4(3.8-9.5)vs 3.0(0.3-6.2)mg/L,P=0.003;adalimumab:9.2(6.5-12.0)vs 5.4(2.5-8.3)mg/L,P=0.004].For patients on infliximab,fistula healing was associated with lower rates of detectable anti-infliximab antibodies and younger age.For patients on adalimumab,fistula healing was associated with higher rates of combination therapy with an immunomodulator.Serum trough levels for patients with and without fistula closure were not significantly different for infliximab[6.9(4.3-10.2)vs 5.5(2.5-8.3)mg/L,P=0.105]or adalimumab[10.0(6.6-12.0)vs 7.8(4.2-10.0)mg/L,P=0.083].CONCLUSION Higher maintenance infliximab and adalimumab trough levels are associated with perianal fistula healing in CD. | Bonita Gu Kavya Venkatesh Astrid-Jane Williams Watson Ng Crispin Corte Ali Gholamrezaei Simon Ghaly Wei Xuan Sudarshan Paramsothy Susan Connor | 2022 | World Journal of Gastroenterology2022，28，23： | 2 |
| 4 | Genetic and environmental control of fruit maturation,dry matter and firmness in apple(Malus×domestica Borkh.)显示文摘For any given genotype,the environment in which an apple is grown can influence the properties of the fruit considerably.While there has been extensive research on the mechanism of the genetic control of fruit quality traits,less effort has been made to investigate the way that these genetic mechanisms interact with the environment.To address this issue,we employed a large‘Royal Gala’בBraeburn’population of 572 seedlings replicated over sites in three climatically diverse apple-growing regions in New Zealand.Phenotyping for traits including fruit maturation timing,firmness and dry matter content was performed at each of these three sites for a single growing season(2011),and at two sites(Motueka and Hawke’s Bay)for two seasons(2009 and 2010).The phenotype data collected over 2 years at two sites enabled the detection of 190 quantitative trait loci(QTL)that controlled these traits regardless of year or growing location,as well as some chromosomal loci that influenced the traits in a single given environment or year.For those loci that were environmentally stable over three sites,there was an interdependency of fruit maturation date,dry matter content and storage potential within this population,with two regions on Linkage Groups(LGs)10 and 16 strongly contributing.If these loci were used in a marker-assisted selection programme to select for progeny bearing firmer fruit,this would have the unintentional consequence of selecting,high dry matter content,later maturing apples.In addition,a further 113 new QTLs with a smaller effect were identified,some of which were exhibited only in a single growing environment,demonstrating the underlying complexity of control of traits determining fruit quality,in addition to the need for being aware of environmental effects when developing new apple varieties. | David Chagne Daya Dayatilake Robert Diack Murray Oliver Hilary Ireland Amy Watson Susan E Gardiner Jason W Johnston Robert J Schaffer Stuart Tustin | 2014 | Horticulture Research2014，1，1： | 2 |
| 5 | Food allergy显示文摘 | Susan Waserman Wade Watson | | 0，，1： | 1 |
| 6 | Predic-ting Cyanobacteria dominance in lakes显示文摘 | John A Downing Susan B Watson Mccauley E | 2001 | Fisheries andAquatic Sciences2001，58，10： | 1 |
| 7 | Education to reduce impact in forest campgrounds显示文摘 | Susan Oliver Joseph Roggenbuck Alan Watson | 1985 | Journal of Forestry1985，83，4： | 1 |
| 8 | EPSPS gene amplification in glyphosate‐resistant Italian ryegrass ( Lolium perenne ssp. multiflorum ) from Arkansas显示文摘 | Reiofeli A Salas Franck E Dayan Zhiqiang Pan Susan B Watson James W Dickson Robert C Scott Nilda R Burgos | 2012 | Pest. Manag. Sci2012，，9： | 1 |
| 9 | Prospective single-blinded single-center randomized controlled trial of Prep Kit-C and Moviprep:Does underlying inflammatory bowel disease impact tolerability and efficacy?显示文摘BACKGROUND Colonoscopy remains the gold standard for detection of colonic disease.An optimal evaluation depends on adequate bowel cleansing.Patients with inflammatory bowel disease(IBD),require frequent endoscopic assessment for both activity and dysplasia assessment.Two commonly used bowel preparations in Australia are Prep Kit-C(Pc)and Moviprep(Mp).Little is known about tolerability,efficacy and safety of split protocols of Mp and Pc in both IBD and non-IBD patients.AIM To primary aim was to compare the tolerability,efficacy and safety of split protocols of Mp and Pc in patients having a colonoscopy.The secondary aim was to compare the efficacy,tolerability and safety of either preparation in patients with or without IBD.METHODS Patients were randomized to Pc or Mp bowel preparation.Patients completed a questionnaire to assess tolerability.Efficacy was assessed using the Ottawa Bowel Preparation Score.Serum electrolytes and renal function were collected one week prior to colonoscopy and on the day of colonoscopy.RESULTS Of 338 patients met the inclusion criteria.Of 168 patients randomized to Mp and 170 to Pc.The efficacy of bowel preparation(mean Ottawa Bowel Preparation Score)was similar between Mp(5.4±2.4)and Pc(5.1±2.1)(P=0.3).Mean tolerability scores were similar in Mp(11.84±5.4)and Pc(10.99±5.2;P=0.17).125 patients had IBD(73 had Crohn’s Disease and 52 had Ulcerative colitis).Sixtyfour IBD patients were allocated to Mp and 61 to Pc.In non-IBD patients,104 were allocated to Mp and 109 to Pc.The mean tolerability score in the IBD group was lower than the non-IBD group(mean tolerability scores:IBD:10.3±5.1 and non-IBD:12.0±5.3;P=0.01).IBD patients described more abdominal pain with Mp when compared with Pc;(Mp:5.7±4.4 vs Pc:3.6±2.6,P=0.046).Serum magnesium level increased with Pc compared with Mp in all patients(mean increase in mmol/L:Mp:0.03±0.117 and Pc:0.11±0.106;P<0.0001).CONCLUSION In this study,the efficacy,tolerability and safety of Mp and Pc were similar in all patients.However,patients with IBD reported lower tolerability with both preparations.Specifically,IBD patients had more abdominal pain with Mp.These results should be considered when recommending bowel preparation especially to IBD patients. | Waled Mohsen Astrid-Jane Williams Gabrielle Wark Alexandra Sechi Jenn-Hian Koo Wei Xuan Milan Bassan Watson Ng Susan Connor | 2021 | World Journal of Gastroenterology2021，27，11： | 1 |
| 10 | Economic loss and directors' negligence显示文摘 | Andrew Willekes Susan Watson | 2001 | Journal of Business Law2001，，： | 1 |
| 11 | Blood-brain barrier integrity may be threatened by exercise in a warm environment显示文摘 | PHILLIP WATSON SUSAN M SHIRREFFS RONALD J M | 2005 | Am J Physiol Regul Integr Comp Physiol2005，288，： | 1 |
| 12 | Combining Kohonen Maps with ARIMA Time Series Models to Forecast Traffic Flow显示文摘 | Mascha Der Voort Mark Doughert Susan Watson | 1996 | Transportation Research1996，，： | 1 |
| 13 | Combining Kohonen maps with ARIMA time series models to forecast traffic flow 显示文摘 | Mascha Dougherty Mark Watson Susan | 1996 | Transportation Research Part C:Emerging Technologies v 4 n 5 Oct1996，1996，： | 1 |
| 14 | Comparative Histopathologic Consequences of Photothrombotic Occlusion of the Distal Middle Cerebral Artery in Sprague-Dawley and Wistar Rats显示文摘 | Carrie G. Markgraf Susan Kraydieh Ricardo Prado Brant D. Watson W. Dalton Dietrich Myron D. Ginsberg | 1993 | Stroke1993，，2： | 1 |
| 15 | Self-reported narcissism and shame: Testing the defensive self-esteem and continuum hypotheses显示文摘 | P.J. Watson Susan E. Hickman Ronald J. Morris | 1996 | Personality and Individual Differences1996，，2： | 1 |
| 16 | 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults显示文摘 | Neil J. Stone Jennifer Robinson Alice H. Lichtenstein C. Noel Bairey Merz Donald M. Lloyd-Jones Conrad B. Blum Patrick McBride Robert H. Eckel J. Sanford Schwartz Anne C. Goldberg Susan T. Shero David Gordon Sidney C. Smith Daniel Levy Karol Watson Peter | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 17 | Should we use neural networks or statistical models for short-term motorway traffic forecasting?显示文摘 | Howard R. Kirby Susan M. Watson Mark S. Dougherty | 1997 | International Journal of Forecasting1997，，1： | 1 |
| 18 | Predicting cyanobacteria dominance in lakes 显示文摘 | Downing John A Watson Susan B Cauley Edward Mc | 2001 | Canadian Journal of Fisheries and Aquatic Sciences2001，58，： | 1 |
| 19 | Quantitative analysis of trace levels of geosmin and MIB in source and drinking water using headspace SPME显示文摘 | Susan B. Watson Brian Brownlee Trevor Satchwill Erika E. Hargesheimer | 2000 | Water Research2000，，10： | 1 |
| 20 | Combining kohonen maps with arima time series models to forecast traffic flow显示文摘 | MASCHAVAN DER VOORT MANK DONGHERTY SUSAN WATSON | 1996 | Transpn Res C1996，4，5： | 1 |
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