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3篇 您的检索式：作者名="Mark Donowitz"

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		题名	作者	年代	出处	被引量
	1	Intestinal enteroids/organoids: A novel platform for drug discovery in inflammatory bowel diseases显示文摘The introduction of biologics such as anti-tumor necrosis factor(TNF)monoclonal antibodies followed by anti-integrins has dramatically changed the therapeutic paradigm of inflammatory bowel diseases(IBD).Furthermore,a newly developed anti-p40 subunit of interleukin(IL)-12 and IL-23(ustekinumab)has been recently approved in the United States for patients with moderate to severe Crohn’s disease who have failed treatment with anti-TNFs.However,these immunosuppressive therapeutics which focus on anti-inflammatory mechanisms or immune cells still fail to achieve long-term remission in a significant percentage of patients.This strongly underlines the need to identify novel treatment targets beyond immune suppression to treat IBD.Recent studies have revealed the critical role of intestinal epithelial cells(IECs)in the pathogenesis of IBD.Physical,biochemical and immunologic driven barrier dysfunctions of epithelial cells contribute to the development of IBD.In addition,the recent establishment of adult stem cell-derived intestinal enteroid/organoid culture technology has allowed an exciting opportunity to study human IECs comprising all normal epithelial cells.This long-term epithelial culture model can be generated from endoscopic biopsies or surgical resections and recapitulates the tissue of origin,representing a promising platform for novel drug discovery in IBD.This review describes the advantages of intestinal enteroids/organoids as a research tool for intestinal diseases,introduces studies with these models in IBD,and gives a description of the current status of therapeutic approaches in IBD.Finally,we provide an overview of the current endeavors to identify a novel drug target for IBD therapy based on studies with human enteroids/organoids and describe the challenges in using enteroids/organoids as an IBD model.	Jun-Hwan Yoo Mark Donowitz	2019	World Journal of Gastroenterology2019，25，30：	8
	2	The burden of selected digestive diseases in the United States显示文摘	Robert S. sandler James E. Everhart Mark Donowitz Elizabeth Adams Kelly Cronin Clifford Goodman Eric Gemmen Shefali Shah Aida Avdic Robert Rubin	2002	Gastroenterology2002，，5：	2
	3	Translational Approaches for Pharmacotherapy Development for Acute Diarrhea显示文摘	Mark Donowitz David H. Alpers Henry J. Binder Thomas Brewer Jill Carrington Michael J. Grey	2012	Gastroenterology2012，，3：	1

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