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| 1 | Novel fibrin-fibronectin matrix accelerates mice skin wound healing显示文摘Plasma fibrinogen(F1)and fibronectin(pFN)polymerize to form a fibrin clot that is both a hemostatic and provisional matrix for wound healing.About 90%of plasma F1 has a homodimeric pair ofγchains(γγF1),and 10%has a heterodimeric pair ofγand more acidicγ′chains(γγ′F1).We have synthesized a novel fibrin matrix exclusively from a 1:1(molar ratio)complex ofγγ′F1 and pFN in the presence of highly active thrombin and recombinant Factor XIII(rFXIIIa).In this matrix,the fibrin nanofibers were decorated with pFN nanoclusters(termedγγ′F1:pFN fibrin).In contrast,fibrin made from 1:1 mixture ofγγF1 and pFN formed a sporadic distribution of“pFN droplets”(termedγγF1+pFN fibrin).Theγγ′F1:pFN fibrin enhanced the adhesion of primary human umbilical vein endothelium cells(HUVECs)relative to theγγF1+FN fibrin.Three dimensional(3D)culturing showed that theγγ′F1:pFN complex fibrin matrix enhanced the proliferation of both HUVECs and primary human fibroblasts.HUVECs in the 3Dγγ′F1:pFN fibrin exhibited a starkly enhanced vascular morphogenesis while an apoptotic growth profile was observed in theγγF1+pFN fibrin.Relative toγγF1+pFN fibrin,mouse dermal wounds that were sealed byγγ′F1:pFN fibrin exhibited accelerated and enhanced healing.This study suggests that a 3D pFN presentation on a fibrin matrix promotes wound healing. | Carlos Poblete Jara Ou Wang Thais Paulino do Prado Ayman Ismail Frank Marco Fabian Han Li Licio A.Velloso Mark A.Carlson William Burgess Yuguo Lei William H.Velander Eliana P.Araújo | 2020 | Bioactive Materials2020，5，4： | 5 |
| 2 | Catabolism of Branched Chain Amino Acids Supports Respiration but Not Volatile Synthesis in Tomato Fruits显示文摘分支链氨基酸 transaminases (BCAT ) 在分支链氨基酸白氨酸,异白氨酸,和缬氨酸的新陈代谢有一个关键角色。这些酶催化合成的最后步和这些氨基酸的降级的起始的步。尽管在植物的分叉的链氨基酸的 biosynthetic 小径广泛地被调查了,很多基因被描绘了,他们在植物的分解代谢完全还没被理解。我们以前在西红柿描绘了分叉的链氨基酸 transaminase 基因家庭,揭示 subcellular 本地化和六基因编码的酶的运动性质。这里,我们在水果开发期间检验了酶的可能的功能。我们进一步描绘了在分叉的链氨基酸 transaminases 的表示不同的转基因的植物 1 和 3,在线 overexpressing 任何一个 BCAT1 或 BCAT3 在在 BCAT1 和 volatiles 的层次缺乏的水果评估呼吸的率。我们测试的份量上经由喂实验的先锋和同位素,在水果 volatiles 的形成的分叉的链氨基酸和他们的相应 keto 酸的重要性。我们的结果不仅第一次在水果呼吸表明分叉的链氨基酸的重要性,而且揭示那 keto 酸,而非氨基酸,是为分叉的链风味 volatiles 的可能的先锋。 | Andrej Kochevenko Wagner L. Araujo Gregory S. Maloney Denise M. Tieman Phuc Thi Do Mark G. Taylor Harry J. Klee Alisdair R. Fernie | 2012 | Molecular Plant2012，5，2： | 4 |
| 3 | Treatment of traumatic cervical arteriovenous fistulas with N-butyl-2- cyanoacrylate 显示文摘 | Jayaraman M V Do H M Marks M P | 2007 | Am J Neuroradiol2007，28，2： | 1 |
| 4 | lntracranial angioplasty without stenting for symptomatic atherosclerotic stenosis long-termfollow-up显示文摘 | Marks MP Marcellus ML Do HM | 2005 | kJNR Am J Neuroradiol2005，26，3： | 1 |
| 5 | Blood levels of vitamin D in teens and young adults with myopia显示文摘 | MUTTI DO MARKS A R | | 0，，03： | 1 |
| 6 | Minimally invasive colorectal surgery显示文摘 | Marks JH Nassif Do GJ Frenkel JL | 2012 | Minerva Gastroenterol Dietol2012，58，3： | 1 |
| 7 | Effects of Stepwise Ablation of Chronic Atrial Fibrillation on Atrial Electrical and Mechanical Properties显示文摘 | Mark DO Michel H | 2007 | J Am Coll Cardiol2007，49，11： | 1 |
| 8 | Arterial spin-labeling MRI can identify the presence and intensity of collateral perfusion in patients with moyamoya disease 显示文摘 | Zaharchuk G Do HM Marks MP | 2011 | Stroke2011，42，： | 1 |
| 9 | Blood levels of vitamin D in teens and young adults with myopia显示文摘 | Mutti DO Marks AR | | 0，，： | 1 |
| 10 | Analytic Reviews: cardiac surgery as a cause of acute kidney injury: pathogenesis and po- tential therapies 显示文摘 | Mitchell HR Didier P and Mark DO | 2008 | J Intensive Care Med2008，23，： | 1 |
| 11 | Review of the lubrication of metallic surfaces by zinc dialkyl-dithiophates显示文摘 | Mark A Nicholls Than Do Peter R Norton | 2005 | Tribology International2005，38，： | 1 |
| 12 | Minimally invasive colo- rectal surgery显示文摘 | Marks JH Nassif Do GJ Frenkel JL | 2012 | Minerva Gastroenterol Dietol2012，58，3： | 1 |
| 13 | Arterial spin-labeling MRI can identify the presence and intensity of collateral perfusion in patients with moyamoya disease显示文摘 | Zaharchuk G Do HM Marks MP | 2011 | Stroke2011，42，： | 1 |
| 14 | Intracranial angioplasty without stenting for symptomatic atheroselerotic stenosis: long- term follow-up显示文摘 | Marks MP Marcellus ML Do HM | 2005 | AJNR2005，26，： | 1 |
| 15 | Arterial spin-labeling MRI can identify the presence and intensity of collateral perfusion in pa- tients with moyamoya disease 显示文摘 | Zaharchuk G Do HM Marks MP | 2011 | Stroke2011，42，9： | 1 |
| 16 | Localized mandibular enlargement in end-stage renal disease: two case reports and a review of the literature显示文摘 | Mark A. Lerman Catherine Do Lakshman Gunaratnam Cyelee Kulkarni Kevin Tucker Sook-Bin Woo | 2012 | Oral Surgery Oral Medicine Oral Pathology and Oral Radiology2012，，3： | 1 |
| 17 | Laparoscopic cholecystostomy with delayed cholecystectomy as an alterantive to conversion to open procedure显示文摘 | Kuster GG Do mark D | 1966 | Surg Endosc1966，10，4： | 1 |
| 18 | Intracranial angioplasty without stenting for symptomatic atherosclerotic stenosis:long-term follow-up显示文摘 | Marks MP Marcellus ML Do HM | 2005 | AJNR2005，26，： | 1 |
| 19 | Minimally invasive colorectal surgery显示文摘 | Marks JH Nassif Do GJ Frenkel JL | 2012 | Minerva Gastroenterol Dietol2012，58，3： | 1 |
| 20 | Blood levels of vitamin D in teens and young adults with myopia显示文摘 | MUTTI DO MARKS AR | | 0，，03： | 1 |
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