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| 1 | Comparison of the liver stiffness measurement by transient elastography with the liver biopsy显示文摘AIM: To compare the liver stiffness (LS) measurement by transient elastography (TE) to the liver biopsy (LB)-considered the 'gold standard' in the evaluation of patients with chronic hepatitis C. METHODS: During a period of 12 mo, we evaluated 199 consecutive patients with chronic hepatitis due to hepatitis C virus (HCV), in which LB and LS assessments (by means of TE) were performed during the same session. RESULTS: Out of 199 patients, a valid measurement of the LS could not be obtained in 8. The mean value of LS in the cohort of 191 valid measurements was 8.45 ± 4.96 kPa, ranging from 2.3 to 38 kPa. The mean value of LS in patients with signifi cant fi brosis at biopsy (161 patients with F ≥ 2 according to Metavir) was 9.02 ± 5.15 kPa, significantly higher than in patients with no or mild fi brosis (30 patients with F < 2 Metavir): 5.39 ± 1.81 kPa (P < 0.0001). For a cut- off value of 6.8 kPa, the LS had a PPV of 98%, a NPV of 30.1%, a sensitivity of 59.6% and a specificity of 93.3% for the presence of signifi cant fi brosis (at least F2 Metavir), with a diagnostic performance of 77.3% (AUROC 0.773). Using this cut-off value, we reached the best discrimination between absence of fibrosis/ mild fibrosis (F < 2 Metavir) and the presence ofmoderate to severe fi brosis (F ≥ 2 Metavir). CONCLUSION: In patients with chronic hepatitis due to HCV, a cut-off value of 6.8 kPa measured by TE can differentiate between significant fibrosis and absent or mild fi brosis, with a PPV of 98%, a NPV of 30.1%, a sensitivity of 59.6%, a specificity of 93.3%, and a diagnostic performance of 77.3%. | Ioan Sporea Roxana ■irli Alexandra Deleanu Adriana Tudora Manuela Curescu Marioara Cornianu Daniela Lazǎr | 2008 | World Journal of Gastroenterology2008，14，42： | 20 |
| 2 | New advances in targeted gastric cancer treatment显示文摘Despite a decrease in incidence over past decades,gastric cancer remains a major global health problem. In the more recent period, survival has shown only minor improvement, despite significant advances in diagnostic techniques, surgical and chemotherapeutic approaches, the development of novel therapeutic agents and treatment by multidisciplinary teams. Because multiple genetic mutations, epigenetic alterations, and aberrant molecular signalling pathways are involved in the development of gastric cancers, recent research has attempted to determine the molecular heterogeneity responsible for the processes of carcinogenesis, spread and metastasis. Currently, some novel agents targeting a part of these dysfunctional molecular signalling pathways have already been integrated into the standard treatment of gastric cancer, whereas others remain in phases of investigation within clinical trials. It is essential to identify the unique molecular patterns of tumours and specific biomarkers to develop treatments targeted to the individual tumour behaviour. This review analyses the global impact of gastric cancer, as well as the role of Helicobacter pylori infection and the efficacy of bacterial eradication in preventing gastric cancer development. Furthermore, the paper discusses the currently available targeted treatments and future directions of research using promising novel classes of molecular agents for advanced tumours. | Daniela Cornelia Lazar Sorina Taban Marioara Cornianu Alexandra Faur Adrian Goldis | 2016 | World Journal of Gastroenterology2016，22，30： | 15 |
| 3 | Malignant hepatic vascular tumors in adults: Characteristics,diagnostic difficulties and current management显示文摘Malignant vascular tumors of the liver include rare primary hepatic mesenchymal tumors developed in the background of a normal liver parenchyma. Most of them are detected incidentally by the increased use of performing imaging techniques. Their diagnosis is challenging, involving clinical and imaging criteria, with final confirmation by histology and immunohistochemistry. Surgery represents the mainstay of treatment. Liver transplantation(LT) has improved substantially the prognosis of hepatic epithelioid hemangioendothelioma(HEHE), with 5-year patient survival rates of up to 81%, based on the European Liver Intestine Transplantation AssociationEuropean Liver Transplant Registry study. Unfortunately, the results of surgery and LT are dismal in cases of hepatic angiosarcoma(HAS). Due to the disappointing results of very short survival periods of approximately 6-7 mo after LT, because of tumor recurrence and rapid progression of the disease, HAS is considered an absolute contraindication to LT. Recurrences after surgical resection are high in cases of HEHE and invariably present in cases of HAS. The discovery of reliable prognostic markers and the elaboration of prognostic scores following LT are needed to provide the best therapeutic choice for each patient.Studies on a few patients have demonstrated the stabilization of the disease in a proportion of patients with hepatic vascular tumors using novel targeted antiangiogenic agents, cytokines or immunotherapy. These new approaches,alone or in combination with other therapeutic modalities, such as surgery and classical chemotherapy, need further investigation to assess their role in prolonging patient survival. Personalized therapeutic algorithms according to the histopathological features, behavior, molecular biology and genetics of the tumors should be elaborated in the near future for the management of patients diagnosed with primary malignant vascular tumors of the liver. | Daniela Cornelia Lazar Mihaela Flavia Avram Ioan Romosan Violetta Vacariu Adrian Goldis Marioara Cornianu | 2019 | World Journal of Clinical Oncology2019，10，3： | 7 |
| 4 | The influence of temperature and storage time at RT on nucleation of the β″ phase in a 6082 Al–Mg–Si alloy显示文摘 | C.D Marioara S.J Andersen J Jansen H.W Zandbergen | 2002 | Acta Materialia2002，，3： | 2 |
| 5 | The influence of temperature and storage time at RT on nucleation of the β' phase in a 6082 Al-Mg-Si alloys显示文摘 | Marioara C D Andersen S J Jansen J | 2003 | Acta Materialia2003，51，： | 1 |
| 6 | The structural relation betweenprecipitates in Al-Mg-Si alloys显示文摘 | ANDERSEN S J MARIOARA C D VISSERS R FROSETH A ZANDBERGEN H W | 2007 | Materials Science andEngineering A2007，444，： | 1 |
| 7 | Atomic model for GP-zones in a 6082 Al-Mg-Si system 显示文摘 | MARIOARA C D ANDERSEN S J JANSEN J | 2001 | Acta Materialia2001，49，： | 1 |
| 8 | The crystal structure of the β'phase in Al-Mg-Si alloys显示文摘 | VISSERS R van HUIS M A ZANDBERGEN H W MARIOARA C D | 2007 | Acta Mater2007，55，： | 1 |
| 9 | Crystal structure of the orthorhombic U2 precipitate in the Al-Mg-Si alloy system and its relation to the β'and β' phases显示文摘 | ANDERSEN S J MARIOARA C D FR-SETH A VISSERS R ZANDBERGEN H W | 2005 | Mater Sci Eng A2005，390，： | 1 |
| 10 | Atomic modelfor GPZ in Al-Mg-Si alloy显示文摘 | MARIOARA C D ANDERSEN S J JANSEN J | 2001 | Acta Materialia2001，49，： | 1 |
| 11 | The structural relation between precipitates in Al-Mg-Si alloys显示文摘 | ANDERSEN S J MARIOARA C D VISSERS R FROSETH A ZANDBERGEN H W | 2007 | Mater Sci Eng A2007，444，： | 1 |
| 12 | The crystal structure of theβ′phase in Al-Mg-Si alloys显示文摘 | VISSERS R HUIS M A JANSEN J ZANDBERGEN H W MARIOARA C D ANDERSEN S J | 2007 | Acta Materialia2007，55，11： | 1 |
| 13 | The crystal structure of the β' phase in A1-Mg-Si alloys显示文摘 | VISSERS R HUIS M A V JANSEN J ZANDBERGEN H W MARIOARA C D ANDERSEN S J | 2007 | Acta Materialia2007，55，： | 1 |
| 14 | Single-walled and multi-walled carbon nanotubes promote allergic immune responses in mice显示文摘 | Nygaard UC Hansen JS Samuelsen M Alberg T Marioara CD L(φ)vik M | | 0，，01： | 1 |
| 15 | Z-contrast imaging of the arrangement of Cu in precipitates in 6XXX-series aluminium alloys显示文摘 | H. S. Hasting J. C. Walmsley A. T. J. Van Helvoort C. D. Marioara S. J. Andersen R. Holmestad | 2006 | Philosophical Magazine Letters2006，，9： | 1 |
| 16 | The influence of alloy composition on precipitates of the A1-Mg-Si system 显示文摘 | MARIOARA C D ANDERSEN S J ZANDBERGEN H W HOLMESTAD R | 2005 | Metallurgical and Materials Transactions A2005，36，3： | 1 |
| 17 | The effect of Cu on precipitation in Al-Mg-Si alloys显示文摘 | MARIOARA C D ANDERSEN S J STENE T N | 2007 | Philosophical Magazine2007，87，23： | 1 |
| 18 | A Novel Approach in Cinnamic Acid Synthesis: Direct Synthesis of Cinnamic Acids from Aromatic Aldehydes and Aliphatic Carboxylic Acids in the Presence of Boron Tribromide显示文摘 | Constantin I C Fulga T Marioara O | 2005 | Molecules2005，10，： | 1 |
| 19 | The influence of temperature and sorage time at RT on nucleation of the β' phase in a 6082 Al-Mg-Si alloy显示文摘 | Marioara C D Andersen S J Jansen J | 2003 | Acta materialia2003，51，3： | 1 |
| 20 | Study of intergrown L and Q' precipitates in Al-Mg-Si-Cu alloys显示文摘 | TORSAETER M LEFEBVRE W MARIOARA C D | 2011 | Scripta Materialia2011，64，9： | 1 |
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