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| 1 | New advances in targeted gastric cancer treatment显示文摘Despite a decrease in incidence over past decades,gastric cancer remains a major global health problem. In the more recent period, survival has shown only minor improvement, despite significant advances in diagnostic techniques, surgical and chemotherapeutic approaches, the development of novel therapeutic agents and treatment by multidisciplinary teams. Because multiple genetic mutations, epigenetic alterations, and aberrant molecular signalling pathways are involved in the development of gastric cancers, recent research has attempted to determine the molecular heterogeneity responsible for the processes of carcinogenesis, spread and metastasis. Currently, some novel agents targeting a part of these dysfunctional molecular signalling pathways have already been integrated into the standard treatment of gastric cancer, whereas others remain in phases of investigation within clinical trials. It is essential to identify the unique molecular patterns of tumours and specific biomarkers to develop treatments targeted to the individual tumour behaviour. This review analyses the global impact of gastric cancer, as well as the role of Helicobacter pylori infection and the efficacy of bacterial eradication in preventing gastric cancer development. Furthermore, the paper discusses the currently available targeted treatments and future directions of research using promising novel classes of molecular agents for advanced tumours. | Daniela Cornelia Lazar Sorina Taban Marioara Cornianu Alexandra Faur Adrian Goldis | 2016 | World Journal of Gastroenterology2016，22，30： | 15 |
| 2 | Artificial intelligence as a noninvasive tool for pancreatic cancer prediction and diagnosis显示文摘Pancreatic cancer(PC)has a low incidence rate but a high mortality,with patients often in the advanced stage of the disease at the time of the first diagnosis.If detected,early neoplastic lesions are ideal for surgery,offering the best prognosis.Preneoplastic lesions of the pancreas include pancreatic intraepithelial neoplasia and mucinous cystic neoplasms,with intraductal papillary mucinous neoplasms being the most commonly diagnosed.Our study focused on predicting PC by identifying early signs using noninvasive techniques and artificial intelligence(AI).A systematic English literature search was conducted on the PubMed electronic database and other sources.We obtained a total of 97 studies on the subject of pancreatic neoplasms.The final number of articles included in our study was 44,34 of which focused on the use of AI algorithms in the early diagnosis and prediction of pancreatic lesions.AI algorithms can facilitate diagnosis by analyzing massive amounts of data in a short period of time.Correlations can be made through AI algorithms by expanding image and electronic medical records databases,which can later be used as part of a screening program for the general population.AI-based screening models should involve a combination of biomarkers and medical and imaging data from different sources.This requires large numbers of resources,collaboration between medical practitioners,and investment in medical infrastructures. | Alexandra Corina Faur Daniela Cornelia Lazar Laura Andreea Ghenciu | 2023 | World Journal of Gastroenterology2023，29，12： | 0 |
| 3 | 计算机辅助系统在上消化道内镜质量监测和胃病变评估中的作用显示文摘本文通过文献综述,对计算机辅助系统在食管胃十二指肠镜质量监测和胃病变评估方面的应用价值进行了分析。目前数据表明,计算机辅助系统能为上消化道内镜检查提供良好的质量控制,并能较为准确地检出胃恶性肿瘤及癌前病变,与经验丰富的内镜医师相当,甚至更佳。同时,人工智能(AI)能够为胃癌患者确定最佳治疗策略,即根据肿瘤浸润深度进行内镜或手术切除,从而在保证生活质量和远期预后的同时,避免不必要的手术干预。各种不同算法的AI应用于上消化道内镜检查中,无论是普通的白光内镜,还是一些专业内镜中心所采用的新型内镜技术,都显示出良好的效果。目前在研的一些关于AI及计算机辅助诊断系统嵌入内镜设备的临床试验,其结果值得期待,有望实现AI内镜系统在未来的真实应用,突破当前计算机辅助系统的不足,提高检测效能。这些改进能为胃癌患者提供更好的诊疗策略。而且,将AI算法融入到内镜设备,加之包含内镜图像的大数据,或可进一步拓展上消化道内镜的应用空间,包括远程医疗和疑难病例的会诊。 | Daniela Cornelia Lazar Mihaela Flavia Avram Alexandra Corina Faur Ioan Romosan Adrian Goldis | 2021 | Gastroenterology Report2021，9，3： | 0 |
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