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| 1 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 2 | 神经生长因子增强小胶质细胞的神经保护作用显示文摘小胶质细胞是脑组织内的防御细胞,但在病理和生理条件下,调控小胶质细胞活化的因子并不十分清楚。本研究发现,神经生长因子(NGF)可以增强小胶质细胞的神经保护和抗炎功能。在体内和体外研究中都发现,小胶质细胞表达NGF受体。原代培养小胶质细胞,给予NGF处理,转录本分析结果显示,NGF对小胶质细胞的运动、吞噬和降解吞噬物的能力均产生影响。对功能的研究显示,NGF可增加小胶质细胞的膜运动能力和胞饮作用;在体研究显示,NGF可激活小胶质细胞释放向外整流电流,调节周围谷氨酸能神经元的神经传递。既往研究提示,小胶质细胞有清除脑内Aβ肽的功能,本研究观察了NGF对小胶质细胞吞噬能力的影响。结果显示,NGF可促进小胶质细胞通过Trk A途径清除Aβ,并加速其降解。此外,NGF还可减轻由Aβ导致的炎症激活。特异性激活小胶质细胞还可以减轻由Aβ导致的神经元树突损伤和长时程增强抑制。在对离体脑片的研究中,我们也发现NGF可以促进小胶质细胞吞噬Aβ。综上所述,本研究证实NGF可以促进小胶质细胞活化,活化的小胶质细胞通过抗炎作用减轻Aβ聚集,发挥神经保护作用。 | 唐颖馨 Rizzi C Tiberi A Giustizieri M Marrone MC Gobbo F Carucci NM Meli G Arisi I D'Onofrio M Marinelli S Capsoni S Cattaneo A | 2018 | 神经损伤与功能重建2018，13，2： | 2 |
| 3 | Biotrans- formations of cinnamic and ferulic acid with Actinomycetes显示文摘 | Brunati M Marinelli F Bertolini C | 2004 | Enzyme and Microbial Technology2004，34，1： | 1 |
| 4 | Antimycins, inhibitors ofATP-citrate lyase, from a Streptomyces sp显示文摘 | Barrow C J Oleynek J J Marinelli V | 1997 | J Antibiot1997，50，9： | 1 |
| 5 | Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening 显示文摘 | Cosconati S Marinelli L La Motta C | 2009 | J Med Chem2009，52，18： | 1 |
| 6 | On the nature of mycobacteriophage diversity and host preference显示文摘 | Jacobs-seca D Marinelli L J Bowman C | 2012 | Virology2012，434，2： | 1 |
| 7 | Toll-like receptors 2,-3 and-4 prime microglia but not astrocytes across central nervous system regions for ATP-dependent interleukin-1βrelease显示文摘 | Facci L Barbierato M Marinelli C | 2014 | Sci Rep2014，4，： | 1 |
| 8 | Chemose-lective hydrogenation of unsaturated carbanyl-compounds over group-8 and group-9 titania-supported metal catalyst 显示文摘 | Raa C G English M Marinelli T B L W | 1993 | Stud Surf Sci Catal1993，78，： | 1 |
| 9 | Toll-like receptors2, -3and -4prime microglia but not astrocytes across central nervous system regions for ATP-dependent interleukin-1β release显示文摘 | Facci L Barbierato M Marinelli C | 2014 | Sci Rep2014，4，： | 1 |
| 10 | A comprehensive outlook on intracerebral therapy of malignant gliomas显示文摘 | Buonerba C Di Lorenzo G Marinelli AA | 2011 | Crit Rev Oncol Hematol2011，80，1： | 1 |
| 11 | The stochastic goodwill problem显示文摘 | Marinelli C | 2007 | European Journal of Operational Research2007，176，1： | 1 |
| 12 | Healthcare work- ers and health care - associated infections :knowledge, atti- tudes, and behavior in emergency departments in Italy 显示文摘 | Parmeggiani C Abbate R Marinelli P | 2010 | BMC Infection Diseases2010，23，10： | 1 |
| 13 | Challenges and opportuni-ties in graphene commercialization 显示文摘 | ZURUTUZA A MARINELLI C | 2014 | Nature Nanotechn-ology2014，9，10： | 1 |
| 14 | A survey of knowledge, attitudes, and behavior of Italian dentists toward immunization显示文摘 | Di Giuseppe G Nobile C G Marinelli P | 2007 | Vaccine2007，25，9： | 1 |
| 15 | A comparative study of isolated liver perfusion venous hepatic artery infusion with mitomycin C in rats显示文摘 | Marinelli A van de Velde C J Kuppen PJ | 1990 | Br J Cancer1990，62，6： | 1 |
| 16 | Hepatic sellate cells are not subjected to oxidant stress during iron-induced fibrogenesis in rodents显示文摘 | Montosi G Garut C Marinelli S | 1998 | Hepatology1998，27，6： | 1 |
| 17 | One-dimensional cutting stock with a limited number of open stacks: Bounds and solutions {tom a new integer linear programming model显示文摘 | ARBOB C MARINELLI F VENTURA P | 2016 | International Transactions in Operational Research2016，23，2： | 1 |
| 18 | Healthcare Workers and Health CareAssociated Infections: Knowledge, Attitudes,and Behavior in Emergency Departments in Italy显示文摘 | Parmeggiani C Abbate R Marinelli P | 2010 | BMC Infect Dis2010，23，10： | 1 |
| 19 | Rupture of the distal biceps brachii tendon:conservative treatment versus anatomic reinsertion-clinical and radiological evaluation after 2 years显示文摘 | Chillemi C Marinelli M De Cupis V | | 0，，08： | 1 |
| 20 | Primary synovial chondromatosis of the shoulder:clinical,arthroscopic and histopathological aspects显示文摘 | Chillemi C Marinelli M de Cupis V | 2005 | Knee Surg Sports Tratmatol Arthrosc2005，22，： | 1 |
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