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| 1 | Dabigatran etixilate and traumatic brain injury: Evolving anticoagulants require evolving care plans显示文摘AIM: To investigate the outcomes of trauma patients with traumatic brain injury(TBI) on Dabigatran Etexilate(DE). METHODS: Following IRB approval, all patients taking DE who were admitted to our level 1 trauma service were enrolled in the study. Injury complexity, length of stay(LOS), intensive care length of stay, operative intervention, therapeutic interventions and outcomes were analyzed retrospectively. RESULTS: Twenty-eight of 4310 admissions were taking DE. Eleven patients were excluded on concurrent antiplatelet therapy. Average age was 77.14 years(64-94 years), and average LOS was 4.7 d(1-35 d). Thirty-two percent were admitted with intracranial hemorrhage. Eighteen percent received factor Ⅶ, and 22% received dialysis in attempts to correct coagulopathy. Mortality was 21%.CONCLUSION: The low incidence, absence of reversal agents, and lack of practice guidelines makes managing patients with TBI taking DE frustrating and provider specific. Local practice guidelines may be helpful in managing such patients. | Sam Pakraftar Daniela Atencio John English Alain Corcos Eric M Altschuler Kurt Stahlfeld | 2014 | World Journal of Clinical Cases2014，2，8： | 3 |
| 2 | Characterization of colonic dendritic cells in normal and colitic mice显示文摘AIM: Recent studies demonstrating the direct involvement of dendritic cells (DC) in the activation of pathogenic T cells in animal models of inflammatory bowel disease identify DC as important antigen presenting cells in the colon. However, very little is known about the properties of colonic DC.METHODS: Using immunohistochemistry, electron microscopy and flow cytometry we have characterized and compared colonic DC in the colon of healthy animals and interleukin-2-deficient (IL2-/-) mice that develop colitis.RESULTS: In the healthy colon, DC resided within the lamina propria and in close association with the basement membrane of colonic villi. Type 1 myeloid (CD11c+, CD11b+,B220-, CD8α-) DC made up the largest (40-45%) population and all DC expressed low levels of CD80, CD86, and CD40,and had high endocytic activity consistent with an immature phenotype. In colitic IL2-/- mice, colonic DC numbers increased four- to five-fold and were localized within the epithelial layer and within aggregates of T and B cells. They were also many more DC in mesenteric lymph nodes (MLN).The majority (>85%) of DC in the colon and MLN of IL2-/-mice were type 1 myeloid, and expressed high levels of MHC class Ⅱ, CD80, CD86, CD 40, DEC 205, and CCR5molecules and were of low endocytic activity consistent with mature DC.CONCLUSION: These findings demonstrate striking changes in the number, distribution and phenotype of DC in the inflamed colon. Their intimate association with lymphocytes in the colon and draining lymph nodes suggest that they may contribute directly to the ongoing inflammation in the colon. | Sheena M Cruickshank Nicholas R English Peter J Felsburg Simon R Carding | 2005 | World Journal of Gastroenterology2005，11，40： | 3 |
| 3 | Examining the contribution of glacial till water to storm runoff using two and three-component hy-drograph separations 显示文摘 | Hinton M J Schiff S L English M C | 1994 | Water Resource Research1994，30，： | 1 |
| 4 | How accurate is CT angiography in evaluating intracranial atherosclerotic disease显示文摘 | Nguyen-Huynh MN Wintermark M English J | 2008 | Stroke2008，39，4： | 1 |
| 5 | The apparent warmth of colors显示文摘 | Morgensen M F English H B | 1926 | Am J Psychol1926，37，： | 1 |
| 6 | Brief exposure to testosterone is sufficient to induce sex differences in rabbit masseter muscle显示文摘 | Reeader M Schwartz G English A W | 2001 | Cells Tiss Org2001，169，： | 1 |
| 7 | Perspectives on deficit irrigation 显示文摘 | English M Raja SN | 1996 | Agri- cultural Water Management1996，32，： | 1 |
| 8 | Caffeine for the manage- ment ofapnea in preterm infants显示文摘 | Mueni E Opiyo N English M | 2009 | Int Health2009，1，2： | 1 |
| 9 | Foodfails to suppress ghrelin levels in obese humans 显示文摘 | ENGLISH P J GHATEI M A MALIK I A | 2002 | The Journal of Clinical Endocrinology & Metabolism2002，87，6： | 1 |
| 10 | Perspectives on deficit irrigation显示文摘 | English M Raja S N | 1996 | Agriculrural Water Management1996，32，： | 1 |
| 11 | Geochemical composition, phosphorus speciation and mass transport of fine-grained sediment in two Lake Erie tributaries显示文摘 | Stone M English M C 1993 | 1993 | Hydrobiologia1993，253，： | 1 |
| 12 | Loss of estrogen ina ctiratian in colonis cancer 显示文摘 | ENGLISH M A kANE K F CRUICKSHANK N | 1999 | J Clin Endocrinol Metab1999，84，6： | 1 |
| 13 | Chemose-lective hydrogenation of unsaturated carbanyl-compounds over group-8 and group-9 titania-supported metal catalyst 显示文摘 | Raa C G English M Marinelli T B L W | 1993 | Stud Surf Sci Catal1993，78，： | 1 |
| 14 | Perspectives on deficit irrigation 显示文摘 | English M Raja S N | 1996 | Ag- riculture Water Management1996，32，： | 1 |
| 15 | Howa-curateis CT Angiographyinevaluating intracrani alatheroscle-roticdisease显示文摘 | Nguyen-Huynh MN Wintermark M English J | 2008 | Stroke2008，，39： | 1 |
| 16 | Perspectives on deficit irrigation显示文摘 | English M Raja S N | 1996 | Agricultural Water Management1996，，32： | 1 |
| 17 | W-Band (75-110 GHz) Microstrip Components显示文摘 | Chang K English D M Tahim R S etal | 1985 | IEEE Trans Microwave Theory & Tech1985，33，12： | 1 |
| 18 | The NewMexico Uniform Trust Code显示文摘 | ENGLISH DAVID M | 2004 | New Mexico Law Review2004，，34： | 1 |
| 19 | Driving privately financed projects in Australia: what makes them tick 显示文摘 | English L M Guthrie J | 2003 | Accounting Auditing & Accountability Journal2003，16，3： | 1 |
| 20 | Surgical management of renal artery aneurysms显示文摘 | English W P Pearce J D Craven T E Wilson D B Edwards M S Ayerdi J | 2004 | J Vasc Surg2004，40，： | 1 |
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