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| 1 | Allergen micro-array detection of specific IgE-reactivity in Chinese allergy patients显示文摘背景变应原微数组是为浆液 IgE-reactivity.In 屏蔽这学习变应原的强大的工具微数组被用来鉴别在选择中国过敏症 patients.Methods 之中统治IgE有约束力的变应原和跨反应的模式学习从广州的城市用耐心的 sera 被进行,南京,有 Dermatophagoides pteronyssinus ( Der p )的 Chengdu 和 Shenyang.In 总数 100 sera 比 50 kU/L 高的特定的IgE水平为对 103 | ZHENG Yi-wu LI Jing LAI Xu-xin ZHAO De-yu LIU Xiao-fan LIN Xiao-ping Birgitte Gjesing Paola Palazzo Adriano Mari ZHONG Nan-shan Michael D Spangfort | 2011 | Chinese Medical Journal2011，，24： | 16 |
| 2 | Transactivation of the TIEG1 confers growth inhibition of transforming growth factor-β-susceptible hepatocellular carcinoma cells显示文摘AIM:To investigate the role of transforming growth factor(TGF)-β-inducible early gene 1(TIEG1) in TGF-β-induced growth inhibition in hepatocellular carcinoma(HCC) cells.METHODS:Human hepatocyte and HCC cell lines with varied susceptibilities to TGF-β1 were tested by methylthiazoletetrazolium(MTT) assay.The expression changes of Smad2,Smad3,Smad4,Smad7,TIEG1 and TIEG2 gene following treatment with TGF-β1 in a TGF-β-sensitive hepatocyte cell line(MIHA),a TGF-β-sensitive hepatoma cell line(Hep3B) and two TGF-β-insensitive hepatoma cell lines(HepG2 and Bel7404) were examined.SiRNA targeting TIEG1 was transfected into Hep3B cells and the sensitivity of cells to TGF-β1 was examined.Overexpression of TIEG1 was induced by lentiviral-mediated transduction in TGF-β1-resistant hepatoma cell lines(Bel7404 and HepG2).MTT assay and 4',6-Diamidino-2-phenylindole staining were used to identify cell viability and apoptosis,respectively.The expression level of stathmin was measured by reverse transcriptase polymerase chain reaction and Western-blotting analysis,and stathmin promoter activity by TIEG1 was monitored by a luciferase reporter gene system.RESULTS:TIEG1 was significantly upregulated by TGF-β1 in the TGF-β1-sensitive HCC cell line,Hep3B,but not in the resistant cell lines.The suppression of TIEG1 by siRNAs decreased the sensitivity of Hep3B cells to TGF-β1,whereas the overexpression of TIEG1 mediated growth inhibition and apoptosis in TGF-β1-resistant HCC cell lines,which resembled those of TGF-β1-sensitive HCC cells treated with TGF-β1.Our data further suggested that stathmin was a direct target of TIEG1,as stathmin was signif icantly downregulated by TIEG1 overexpression,and stathmin promoter activity was inhibited by TIEG1 in a dose-dependent manner.CONCLUSION:Our data suggest that transactivation of TIEG1 conferred growth inhibition of TGF-β-susceptible human HCC cells. | Lei Jiang Yiu-Kay Lai Jin-Fang Zhang Chu-Yan Chan Gang Lu Marie CM Lin Ming-Liang He Ji-Cheng Li Hsiang-Fu Kung | 2012 | World Journal of Gastroenterology2012，18，17： | 13 |
| 3 | Macrophage migration inhibitory factor stimulated by He/icobacter py/oriincreases proliferation of gastric epithelial cells显示文摘AIM: Helicobacter pylori (H pylori) is associated with increased gastric inflammatory and epithelial expression of macrophage migration inhibitory factor (MIF) and gastric epithelial cell proliferation. This study aimed at determining whether H pylori directly stimulates release of MIF in monocytes, whether the cay pathogenicity island (PAI) is involved for this function, and whether MIF stimulated by H pylori increases gastric epithelial cell proliferation in vitro.METHODS: A cytotoxic wild-type H pylori strain (TN2),its three isogenic mutants (TN2△cag, TN2△cagA and TN2△cagE) were co-cultured with cells of a human monocyte cell line, THP-1, for 24 h at different organism/cell ratios. MIF in the supernatants was measured by an ELISA. Cells of a human gastric cancer cell line, MKN45,were then co-cultured with the supernatants, with and without monoclonal anti-MIF antibody for 24 h. The cells were further incubated for 12 h after addition of 3H-thymidine, and the levels of incorporation of 3H-thymidine were measured with a liquid scintillation counter.RESULTS: The wild-type strain and the isogenic mutants,TN2△cagA and TN2△cagE, increased MIF release at organism/cell ratios of 200/1 and 400/1, but not at the ratios of 50/1 and 100/1. However, the mutant TN2△cag did not increase the release of MIF at any of the four ratios.3H-thymidine readings for MKN-45 cells were significantly increased with supernatants derived from the wild-type strain and the mutants TN2△cagA and TN2△cagE, but not from the mutant TN2△cag. Moreover, in the presence of monoclonal anti-MIF antibody, the stimulatory effects of the wild-type strain on cell proliferation disappeared.CONCLUSION: H pylori stimulates MIF release in monocytes, likely through its cag PAI, but not related to cagA or cagE. H pylori-stimulated monocyte culture supernatant increases gastric cell proliferation, which is blocked by anti-MIF antibody, suggesting that MIF plays an important role in H pylori-induced gastric epithelial cell proliferation. | Harry Hua-Xiang Xia Shiu Kum Lam Annie O.O.Chan Marie Chia Mi Lin Hsiang Fu Kung Keiji Ogura Douglas E.Berg Benjamin Chun-Yu Wong | 2005 | World Journal of Gastroenterology2005，11，13： | 12 |
| 4 | Heme oxygenase-1 system and gastrointestinal inflammation:A short review显示文摘Heme oxygenase-1(HO-1) system catalyzes heme to biologically active products:carbon monoxide,biliverdin/bilirubin and free iron.It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes.A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract.This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date.The ability to upregulate HO-1 by pharmacological means or using gene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future. | Xiao Zhu Wen-Guo Fan Dong-Pei Li Hsiangfu Kung Marie CM Lin | 2011 | World Journal of Gastroenterology2011，17，38： | 9 |
| 5 | Ancient migration routes of Austronesian-speaking populations in oceanic Southeast Asia and Melanesia might mimic the spread of nasopharyngeal carcinoma显示文摘Mitochondrial DNA (mtDNA) and non-recombining Y chromosome (NRY) are inherited uni-parentally from mother to daughter or from father to son respectively. Their polymorphism has initially been studied throughout populations of the world to demonstrate the 'Out of Africa' hypothesis. Here, to correlate the distribution of nasopharyngeal carcinoma (NPC) in different populations of insular Asia, we analyze the mtDNA information (lineages) obtained from genotyping of the hyper variable region (HVS I & II) among 1400 individuals from island Southeast Asia (ISEA), Taiwan and Fujian and supplemented with the analysis of relevant coding region polymorphisms. Lineages that best represented a clade (a branch of the genetic tree) in the phylogeny were further analyzed using complete genomic mtDNA sequencing. Finally, these complete mtDNA sequences were used to construct a most parsimonious tree which now constitutes the most up-to-date mtDNA dataset available on ISEA and Taiwan. This analysis has exposed new insights of the evolutionary history of insular Asia and has strong implications in assessing possible correlations with linguistic, archaeology, demography and the NPC distribution in populations within these regions. To obtain a more objective and balanced genetic point of view, slowly evolving biallelic Y single nucleotide polymorphism (Y-SNP) was also analyzed. As in the first step above, the technique was first applied to determine affinities (macro analysis) between populations of insular Asia. Secondly, sixteen Y short tandem repeats (Y-STR) were used as they allow deeper insight (micro analysis) into the relationship between individuals of a same region. Together, mtDNA and NRY allowed a better definition of the relational, demographic, cultural and genetic components that constitute the make up of the present day peoples of ISEA. Outstanding findings were obtained on the routes of migration that occurred along with the spread of NPC during the settlement of insular Asia. The results of this analysis will be discussed using a conceptual approach. | Jean Trejaut Chien-Liang Lee Ju-Chen Yen Jun-Hun Loo Marie Lin | 2011 | Chinese Journal of Cancer2011，30，2： | 7 |
| 6 | Intra-coronary administration of soluble receptor for advanced glycation end-products attenuates cardiac remodeling with decreased myocardial transforming growth factor-pl expression and fibrosis in minipigs with ischemia-reperfusion injury显示文摘 | LU Lin ZHANG Qi XU Yan ZHU Zheng-bin GENG Liang WANG Ling-jie JIN Cao CHEN Qiu-jing Ann Marie Schmidt SHEN Wei-feng | 2010 | Chinese Medical Journal2010，，5： | 5 |
| 7 | Establishment and characterization of a new cell line derived from human colorectal laterally spreading tumor显示文摘AIM:To study the molecular mechanism of laterally spreading tumor (LST), a cell line [Laterally Spreading Tumor-Rectum 1 (LST-R1)] was derived and the characteristics of this cell line were investigated. METHODS:A new cell line (LST-R1) originated from laterally spreading tumor was established. Properties of the cell line were characterized using scanning and transmission electron microscopy, immunohistochemistry method, cytogenetic analysis and nude mice xenograft experiments. In vitro invasion assay, cDNA microarray and Western blotting were used to compare the difference between the LST-R1 and other colorectal cancer cell lines derived from prudent colon cancer. RESULTS:Our study demonstrated that both epithelial special antigen (ESA) and cytokeratin-20 (CK20) were expressed in LST-R1. The cells presented microvilli and tight junction with large nuclei. The karyotypic analysis showed hyperdiploid features with structural chromosome aberrations. The in vivo tumorigenicity was also demonstrated in nude mice xenograft experiments. The invasion assay suggested this cell line has a higher invasive ability. cDNA microarray and Western blotting show the loss of the expression of E-cadherin in LST-R1 cells.CONCLUSION:We established and characterized a colorectal cancer cell line, LST-R1 and LST-R1 has an obvious malignant tendency, which maybe partially attributed to the changes of the expression of some adhesion molecules, such as E-cadherin. It is also a versatile tool for exploring the original and progressive mechanisms of laterally spreading tumor and the early colon cancer genesis. | Xin-Ying Wang Zhou-Sheng Lai Chung-Man Yeung Ji-De Wang Wen Deng Hoi Yee Li Yu-Jing Han Hsiang-Fu Kung Bo Jiang Marie Chia-mi Lin | 2008 | World Journal of Gastroenterology2008，14，8： | 5 |
| 8 | Heme oxygenase-1 system and gastrointestinal tumors显示文摘Heme oxygenase-1(HO-1) system catabolizes heme into three products:carbon monoxide,biliverdin/bilirubin and free iron.It is involved in many physiological and pathophysiological processes.A great deal of data has demonstrated the roles of HO-1 in the formation,growth and metastasis of tumors.The interest in this system by investigators involved in gastrointestinal tumors is fairly recent,and few papers on HO-1 have touched upon this subject.This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal tumors studied to date.The implications for possible therapeutic manipulation of HO-1 in gastrointestinal tumors are also discussed. | Marie CM Lin Hsiangfu Kung | 2010 | World Journal of Gastroenterology2010，16，21： | 4 |
| 9 | Cancer Immunotherapy Targeting the Telomerase Reverse Transcriptase显示文摘人的 telomerase 颠倒 transcriptase (hTERT ) 在超过 85% 肿瘤房间被表示,但是通常没在正常房间被发现,它作为理想的肿瘤伙伴抗原(TAA ) 做 hTERT 开发没有在人的癌症免疫疗法损害正常纸巾,明确地破坏癌症的潜在的疫苗。这被考察 hTERT 或它的肽和早临床的 trials using 的 immunogenicity 上的研究的基本进展在最后十年的 hTERT 疫苗途径。 | Longfei Huo Janice WS Tang Junjian Huang Peitang Huang Cuifen Huang Hsiang-fu Kung Marie C. Lin | 2006 | Cellular & Molecular Immunology2006，3，1： | 4 |
| 10 | Cancer gene therapy targeting angiogenesis:An updated review显示文摘Since the relationship between angiogenesis and tumor growth was established by Folkman in 1971, scientists have made efforts exploring the possibilities in treating cancer by targeting angiogenesis. Inhibition of angiogenesis growth factors and administration of angiogenesis inhibitors are the basics of anti- angiogenesis therapy. Transfer of anti-angiogenesis genes has received attention recently not only because of the advancement of recombinant vectors, but also because of the localized and sustained expression of therapeutic gene product inside the tumor after gene transfer. This review provides the up-to-date information about the strategies and the vectors studied in the field of anti-angiogenesis cancer gene therapy. | Ching-Chiu Liu Zan Shen Hsiang-Fu Kung Marie CM Lin | 2006 | World Journal of Gastroenterology2006，12，43： | 4 |
| 11 | De-oncogenic HPV E6/E7 vaccine gets enhanced antigenicity and promotes tumoricidal synergy with cisplatin显示文摘以便与高风险的人的乳头状瘤病毒(HPV ) 对癌症开发更有效的治疗学的疫苗感染,它对关键提高 immunogenicity,消除 oncoproteins 的 oncogenicity,并且拿包含 E7 和包含 E6 疫苗的联合。它最近被看了那 PE ( III ) -E7-KDEL3 ( E7 ),包含 HPV16 oncoprotein E7 的熔化蛋白质和 Pseudomonas aeruginosa 外毒素 A 的 translocation 域,对因此,在鼠标接种的 TC-1 肿瘤房间是有效的我们设计了 PE ( III ) -E6-CRL-KDEL3 ( E6 ), E7 和 E6 熔化蛋白质的 de-oncogenic 版本[即 PE ( III )-E7(d)-KDEL3, E7 (d),和 PE ( III )-E6(d)-CRL-KDEL3, E6 (d)]并且作为单音测试了这些熔化蛋白质的 immunoefficacies --并且二原子价的疫苗。结果比它的野类型和 E6 熔化蛋白质扩充他们的 E7 对应物的 immunogenicity 和 antitumor 效果的显示 E7 (d) 得到更高的 immunogenicity。而且,面对 cisplatin,加 E6 (d) 的二原子价的疫苗的系统 E7 (d) 在 vivo 对确定的肿瘤显示出最好的 tumoristatic 和 tumoricidal 效果。因此,在进一步的优化之上,这个新奇治疗学的疫苗的系统可以在 HPV 相关的癌的临床的管理上打开新灯,这能被结束。 | Shaochun Chen Chaowei Liao Yiukay Lai Yan Fan Gang Lu Hua Wang Xiaoai Zhang Marie C.M. Lin Shuilong Leng Hsiang-Fu Kung | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 3 |
| 12 | Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus显示文摘AIM: To compare the gene expression profile in a pair of HBV-infected twins.METHODS: The gene expression profile was compared in a pair of HBV-infected twins.RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins.CONCLUSION: TNF-αIP1 may play a role in the innate immunity against HBV. | Marie C Lin Nikki P Lee Ning Zheng Pai-Hao Yang Oscar G Wong Hsiang-Fu Kung Chee-Kin Hui John M Luk George Ka-Kit Lau | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 13 | The comparative efficacy of ezetimibe added to atorvastatin 10 mg versus uptitration to atorvastatin 40 mg in subgroups of patients aged 65 to 74 years or greater than or equal to 75 years显示文摘有年龄的背景冠的心疾病(CHD ) 风险增加;然而类脂化合物阴沉的治疗是显著地在病人的 under-utilized > 65 年。目的是评估安全,在更老的病人的类脂化合物阴沉的治疗的功效与 atorvastatin 对待 10 mg + ezetimibe 10 mg (EZ/Atorva ) 对增加 atorvastatin 剂量到 40 mg。方法病人有动脉粥样硬化患者的 65 年脉管的疾病(LDL-C 1.81 mmol/L ) 或在为冠的心的高风险,疾病(LDL-C 2.59 mmol/L ) 为 12 wk 对 uptitration 被使随机化到 EZ/Atorva 到为 6 wk 的 20 mg 由 atorvastatin 跟随了的 atorvastatin 为 6 wk 的 40 mg。在完成 prespecified LDL-C 层次的 LDL-C 和另外的类脂化合物参数和百分比病人的百分比变化在 12 wk 以后被估计。结果 EZ/Atorva 在病人在大多数类脂化合物参数对 atorvastatin 的 uptitration 生产了更大的减小 75 年(n = 228 ) ,与病人通常一致 6574 年(n = 812 ) 。更多的病人在 6 wk 并且在病人在两个年龄组与联合治疗对 monotherapy 完成了 LDL-C 目标在 12 wk 的 75 年。在 12 wk,更多的病人 75 年与 monotherapy 对联合治疗完成了 LDL-C 目标。EZ/Atorva 在大多数类脂化合物生产了更有利的改进对加倍或 quadrupling 在病人的 atorvastatin 剂量 75 年,与在病人的调查结果通常一致 6574 年。我们的结果扩大了证明 ezetimibe 增加了 statin 的以前的调查结果的结论为在病人改进类脂化合物侧面提供了一种通常容忍得好的治疗学的选择 65 ~ 74 年和 75 岁。 | Ori Ben-Yehuda Nanette K. Wenger Christian Constance Franklin Zieve Mary E. Hanson Jian-Xin Lin Arvind K. Shah Charlotte Jones-Burton Andrew M. Tershakovec | 2011 | Journal of Geriatric Cardiology2011，8，1： | 2 |
| 14 | Transcriptome analysis of near-isogenic lines provides molecular insights into starch biosynthesis in maize kernel显示文摘Starch is the major component in maize kernels,providing a stable carbohydrate source for humans and livestock as well as raw material for the biofuel industry.Increasing maize kernel starch content will help meet industry demands and has the potential to increase overall yields.We developed a pair of maize near-isogenic lines(NILs) with different alleles for a starch quantitative trait locus on chromosome 3(q HS3), resulting in different kernel starch content. To investigate the candidate genes for q HS3 and elucidate their effects on starch metabolism, RNA-Seq was performed for the developing kernels of the NILs at 14 and 21 d after pollination(DAP). Analysis of genomic and transcriptomic data identified 76 genes with nonsynonymous single nucleotide polymorphisms and 384 differentially expressed genes(DEGs) in the in trogressed fragment, including a hexokinase gene, Zm HXK3 a, which catalyzes the conversion of glucose to glucose-6-phosphate and may play a key role instarch metabolism. The expression pattern of all DEGs in starch metabolism shows that altered expression of the candidate genes for q HS3 promoted starch synthesis,with positive consequences for kernel starch content. These results expand the current understanding of starch biosynthesis and accumulation in maize kernels and provide potential candidate genes to increase starch content. | Yingni Xiao Shawn Thatcher Min Wang Tingting Wang Mary Beatty Gina Zastrow-Hayes Lin Li Jiansheng Li Bailin Li Xiaohong Yang | 2016 | Journal of Integrative Plant Biology2016，58，8： | 2 |
| 15 | Expression Profile and Function Analysis of Long Non-coding RNAs in the Infection of Coxsackievirus B3显示文摘The roles of IncRNAs in the infection of enteroviruses have been barely demonstrated.In this study,we used coxsackievirus B3(CVB3),a typical enterovirus,as a model to investigate the expression profiles and functional roles of IncRNAs in enterovirus infection.We profiled IncRNAs and mRNA expression in CVB3-infected HeLa cells by IncRNA-mRNA integrated microarrays.As a result,700 differentially expressed IncRNAs(431 up-regulated and 269 down-regulated)and 665 differentially expressed mRNAs(299 up-regulated and 366 down-regulated)were identified in CVB3 infection.Then we performed IncRNA-mRNA integrated pathway analysis to identify potential functional impacts of the differentially expressed mRNAs,in which IncRNA-mRNA correlation network was built.According to IncRNA-mRNA correlation,we found that XLOC-001188,an IncRNA down-regulated in CVB3 infection,was negatively correlated with NFAT5 mRNA,an anti-CVB3 gene reported previously.This interaction was supported by qPCR detection following siRNA-mediated knockdown of XLOC-001188,which showed an increase of NFAT5 mRNA and a reduction of CVB3 genomic RNA.In addition,we observed that four most significantly altered IncRNAs,SNHG11,RP11-145F16.2,RP11-1023L17.1 and RP11-1021N1.2 share several common correlated genes critical for CVB3 infection,such as BRE and IRF2BP1.In all,our studies reveal the alteration of IncRNA expression in CVB3 infection and its potential influence on CVB3 replication,providing useful information for future studies of enterovirus infection. | Lei Tong Ye Qiu Hui Wang Yunyue Qu Yuanbo Zhao Lexun Lin Yan Wang Weizhen Xu Wenran Zhao Hongyan He Guangze Zhao Mary HZhang Decheng Yang Xingyi Ge Zhaohua Zhong | 2019 | Virologica Sinica2019，34，6： | 2 |
| 16 | Artificial cold exposure induced stroke in renovascular hypertensive rats and its association with cold-inducible RNA binding protein mRNA expression in brain tissue and blood pressure显示文摘BACKGROUND: High incidence of stroke at interchange period of autumn and winter was demonstrated by epidemiological survey, and the specific causes should be further investigated. OBJECTIVE: To investigate the influence of artificial cold exposure on the incidence of stroke in renovascular hypertensive rats (RHR), and analyze the association with blood pressure and cold-inducible RNA binding protein (CIRP) mRNA expression in brain tissue. DESIGN: A completely randomized grouping design, a randomized control animal trial. SETTINGS: Lab of Neurology, the First Affiliated Hospital of Sun Yat-sen University; Department of Chemistry, Open laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong. MATERIALS: Male SD rats (n =460), weighing 80-100 g were obtained from Guangdong Province Health Animal Unit. A modified RXZ-300A intelligent artificial climate cabinet (Ningbo Jiangnan Instrument Co.,Ltd., China). METHODS: The experiment were processed in the Lab of Neurology, the First Affiliated Hospital of Sun Yat-sen University and the Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong from October 2004 to November 2005. Rats (n = 400) were operated to establish 2-kidney 2-clip RHR model as described previously. The sham-operated rats (n =60) served as normotensive controls. Eight weeks later, 300 of RHR were randomly selected according to their systolic blood pressure (SBP) and divided into 3 sub-groups (n =100 per group): mild hypertensive group (SBP of 160-200 mm Hg), moderate hypertensive group (SBP of 200-220 mm Hg) and severe hypertensive group (SBP > 220 mm Hg). Each group was further divided into two groups (n =50) under ACE and non-ACE. Normal sham-operated SD rats (n =60), SBP < 140 mm Hg, were randomly divided into two groups: Sham-operated control group (n =30) under ACE and non-ACE. To establish the ACE and non-ACE treatment, rats were housed individually in artificial climate cabinet, and ACE was designed as three cycles of 12-hour light of 22 ℃ (7∶00-19∶00) and 12-hour dark of 4 ℃(19∶00-7∶00). The non-ACE group was kept at 22 ℃ throughout the experiment. MAIN OUTCOME MEASURES: Blood Pressure changes were measured and stroke symptom were observed; Expression of the CIRP were examined by reverse transcription-polymerase chain reaction. RESULTS: Finally 360 rats were involved in the analysis of results. ① Incidence of stroke: The incidence of stroke in 2k2c RHR was significantly higher after a three-day intermittent (12-hour) ACE (29.3%) as compared with that in non-ACE (17.3%) (P < 0.05). Furthermore, the severe hypertensive 2k2c RHR (BP > 220 mm Hg) was found to have much higher incidence of stroke (66%, 33/50) than the mild (8%, 4/50) and moderate (18%) hypertensive 2k2c RHR. ② CIRP mRNA in brain tissue: ACE treatment stimulated the mRNA expression of CIRP in non-stroke 2k2c RHR but not in stroke 2k2c RHR (P < 0.05). CONCLUSION: High blood pressure and low expression of CIRP are associated with ACE induced stroke. | Xiaoaena Shi Jianwen Lin Ying Peng Lally L.K. Chan Hsiang Fu Kung Marie C. Lin Ruxun Huang | 2007 | Neural Regeneration Research2007，2，8： | 2 |
| 17 | Access to Occupations through Social Ties 显示文摘 | Lin Nan Mary Dumin | 1986 | Social Networks1986，8，4： | 1 |
| 18 | Suppression of microR- NA - silencing pathway by HIV - 1 during virus replication 显示文摘 | TRIBOULET R MARI B LIN Y L | 2007 | Science2007，315，5818： | 1 |
| 19 | High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA显示文摘Normal high-density lipoprotein(nHDL)can induce angiogenesis in healthy individuals.However,HDL from patients with coronary artery disease undergoes various modifications,becomes dysfunctional(dHDL),and loses its ability to promote angiogenesis.Here,we identified a long non-coding RNA,HDRACA,that is involved in the regulation of angiogenesis by HDL.In this study,we showed that nHDL downregulates the expression of HDRACA in endothelial cells by activating WW domain-containing E3 ubiquitin protein ligase 2,which catalyzes the ubiquitination and subsequent degradation of its transcription factor,Kruppel-like factor 5,via sphingosine 1-phosphate(S1P)receptor 1.In contrast,dHDL with lower levels of S1P than nHDL were much less effective in decreasing the expression of HDRACA.HDRACA was able to bind to Ras-interacting protein 1(RAIN)to hinder the interaction between RAIN and vigilin,which led to an increase in the binding between the vigilin protein and proliferating cell nuclear antigen(PCNA)mRNA,resulting in a decrease in the expression of PCNA and inhibition of angiogenesis.The expression of human HDRACA in a hindlimb ischemia mouse model inhibited the recovery of angiogenesis.Taken together,these findings suggest that HDRACA is involved in the HDL regulation of angiogenesis,which nHDL inhibits the expression of HDRACA to induce angiogenesis,and that dHDL is much less effective in inhibiting HDRACA expression,which provides an explanation for the decreased ability of dHDL to stimulate angiogenesis. | Zhi-Wei Mo Yue-Ming Peng Yi-Xin Zhang Yan Li Bi-Ang Kang Ya-Ting Chen Le Li Mary GSorci-Thomas Yi-Jun Lin Yang Cao Si Chen Ze-Long Liu Jian-Jun Gao Zhan-Peng Huang Jia-Guo Zhou Mian Wang Guang-Qi Chang Meng-Jie Deng Yu-Jia Liu Zhen-Sheng Ma Zuo-Jun Hu Yu-Gang Dong Zhi-Jun Ou Jing-Song Ou | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 1 |
| 20 | Suppression of microRNA-silencing pathway by HIV-1 during virus replication显示文摘 | Triboulet R Mari B Lin Y L | 2007 | Science2007，315，15： | 1 |
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