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| 1 | Treatment outcomes for different subgroups of nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy显示文摘Although many studies have investigated intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC),sample sizes in the reported studies are usually small and different in outcomes in different T and N subgroups are seldom analyzed.Herein,we evaluated the outcomes of NPC patients treated with IMRT and further explored treatment strategy to improve such outcome.We collected clinical data of 865 NPC patients treated with IMRT alone or in combination with chemotherapy,and classified all cases into the following prognostic categories according to different TNM stages:early stage group (T1-2N0-1M0),advanced local disease group (T3-4N0-1M0),advanced nodal disease group (T1-2N2-3M0),and advanced locoregional disease group (T3-4N2-3M0).The 5-year overall survival (OS),local relapse-free survival (LRFS),and distant metastases-free survival (DMFS) were 83.0%,90.4%,and 84.0%,respectively.The early disease group had the lowest treatment failure rate,with a 5-year OS of 95.6%.The advanced local disease group and advanced nodal disease group had similar failure pattern and treatment outcomes as well as similar hazard ratios for death (4.230 and 4.625,respectively).The advanced locoregional disease group had the highest incidence of relapse and death,with a 5-year DMFS and OS of 62.3% and 62.2%,respectively,and a hazard ratio for death of 10.402.Comparing with IMRT alone,IMRT in combination with chemotherapy provided no significant benefit to locoregionally advanced NPC.Our results suggest that the decision of treatment strategy for NPC patients should consider combinations of T and N stages,and that IMRT alone for early stage NPC patients can produce satisfactory results.However,for advanced local,nodal,and locoregional disease groups,a combination of chemotherapy and radiotherapy is recommended. | Sheng-Fa Su 1,2,3,Fei Han 1,2,Chong Zhao 1,2,Ying Huang 1,2,Chun-Yan Chen 1,2,Wei-Wei Xiao 1,2,Jia-Xin Li 1,2 and Tai-Xiang Lu 1,2 1 State Key Laboratory of Oncology in South China,Guangzhou,Guangdong 510060,P.R.China 2 Department of Radiation Oncology,Sun Yat-sen University Cancer Center,Guangzhou,Guangdong 510060,P.R.China 3 Department of Oncology,Guiyang Medical College Hospital,Tumor Hospital of Guizhou,Guiyang,Guizhou 550003,P.R.China. | 2011 | Chinese Journal of Cancer2011，30，8： | 40 |
| 2 | Nasopharyngeal carcinoma as a paradigm of cancer genetics显示文摘The unusual incidence patterns for nasopharyngeal carcinoma(NPC) in China,Northeast India,Arctic Inuit,Peninsular and island Southeast Asia,Polynesian Islanders,and North Africans indicate a role for NPC risk genes in Chinese,Chinese-related,and not-obviously Chinese-related populations.Renewed interest in NPC genetic risk has been stimulated by a hypothesis that NPC population patterns originated in Bai-Yue /pre-Austronesian-speaking aborigines and were dispersed during the last glacial maximum by Sundaland submersion.Five articles in this issue of the Chinese Journal of Cancer,first presented at a meeting on genetic aspects of NPC [National Cancer Center of Singapore(NCCS),February 20-21,2010],are directed towards incidence patterns,to early detection of affected individuals within risk populations,and to the application of genetic technology advances to understanding the nature of high risk.Turnbull presents a general framework for understanding population migrations that underlie NPC and similar complex diseases,including other viral cancers.Trejaut et al.apply genetic markers to detail migration from East Asia through Taiwan to the populating of Island Polynesia.Migration dispersal in a westward direction took mongoloid peoples to modern day Northeast India adjacent to Western China(Xinjiang).NPC incidence in mongoloid Nagas ranks amongst the highest in the world,whereas elsewhere in India NPC is uncommon.Cao et al.detail incidence patterns in Southeast China that have occurred over recent decades.Finally,Ji et al.describe the utility of Epstein-Barr virus serostatus in early NPC detection.While genetic risk factors still remain largely unknown,human leukocyte antigen(HLA) genes have been a focus of attention since the discovery of an HLA association with NPC in 1973 and,two years later,that NPC susceptibility in highest-risk Cantonese involved the co-occurrence of multi-HLA locus combinations of HLA genes as chromosome combinations,or haplotypes(e.g.HLA-A2-B46),whereas in relatively lower-risk non-Cantonese Chinese(Hokkiens,Teochews) they appeared to act independently,a strength of association reflecting the 30-50-fold difference in incidence between highest risk Cantonese and lowest-risk Indians.The prototypic haplotype HLA-A2-B46 extends over megabases.An upstream DNA segment(near HLA-DPA1),has close similarity to Gorilla,with no obvious homology to Chimpanzee in current databases,suggesting that a reticulate model of primate evolution may be more appropriate than simple phylogeny.The DNA variation level in this segment is high enough for it to be a hominin remnant.HLA-B46 arose in mongoloids and remains largely limited to Chinese so the question arises as to whether the hominin candidate segment indicates an eastward trek of Homo neanderthalensis or the survival of much earlier Homo erectus? In 2011 sequencing technologies have finally caught up with the requirement to separate parental haplotypes.Recently achieved chromosome separation for whole genome di-haploid genetic and epigenetic analysis of parental inheritance in single individuals will reveal interacting patterns of multi-locus haplotypes as humans move in and through successive environments,thus providing definitive information on the genetic affinities between extant populations,and of the migrations that have led to the global distribution of modern Homo.The challenge can now be met of seeking HLA-associated locations both within and outside the HLA complex on each of the pair of chromosomes.More broadly,for every disease,genetic risk detection will require resolution of the diploid genome as a di-haplome.In the context of NPC,HLA genetic risk complete autosomal di-haplomic sequencing will enable testing of the Wee unitary origin hypothesis of NPC risk even among populations with no apparent mongoloid affinity. | Malcolm J. Simons | 2011 | Chinese Journal of Cancer2011，30，2： | 5 |
| 3 | HLA与鼻咽癌易感风险的研究进展显示文摘鼻咽癌是与病毒相关的癌症,在东南亚和北非地区高发。几组基因连锁分析研究显示,易患性人类白细胞抗原(HLA)等位基因和单倍型与鼻咽癌的发展相关。HLA系统是高度多态性的,根据人类种群研究发现其有能力赋予鼻咽癌易患性或抵抗性。现概述在鼻咽癌发病率不同的各个地区间的HLA阳性、阴性与鼻咽癌流行的信息。根据HLA相关的免疫功能及HLA基因与鼻咽癌易感假基因之间存在的潜在连锁不平衡关系,来重点讨论这些相关性的可能意义。 | 张丽煌 赵亮 阮标 | 2011 | 医学综述2011，17，9： | 3 |
| 4 | Survivin、Bcl-2、Pml的基因表达及其与鼻咽癌临床分期及预后的关系显示文摘目的探讨鼻咽癌(NPC)患者Survivin、Bcl-2、Pml基因的表达情况,分析其与NPC临床分期及预后的关系。方法选取2010年1月~2012年5月本院与合作医院耳鼻喉科门诊收治的55例NPC患者和50鼻咽慢性炎症患者,将其作为临床研究对象。采用实时荧光定量PCR检测组织和外周血中Survivin、Bcl-2和Pml mRNA的表达,同时利用TUNEL法检测细胞的凋亡情况。结果 NPC患者Survivin、Bcl-2、Pml基因表达阳性率分别为68.00%、74.00%、60.00%,均明显高于对照组;Ⅰ、Ⅱ期NPC患者Survivin、Bcl-2基因表达阳性率明显低于Ⅲ、Ⅳ期NPC患者,而Pml基因表达阳性率则明显高于Ⅲ、Ⅳ期NPC者;Survivin、Bcl-2、Pml阳性率患者放疗后1年后的生存率明显低于6个月后,差异具有统计学意义(P<0.05)。结论 NPC患者Survivin、Bcl-2和Pml基因表达呈高阳性率,且Survivin、Bcl-2、Pml基因的表达与临床分期和预后存在密切的相关性,临床上可作为预测NPC放射敏感性和预后的有效指标。 | 何清泉 张冬林 吴肖仙 张建国 | 2013 | 中国当代医药2013，20，16： | 1 |
| 5 | 慢病毒介导RNA干扰Pin1异构酶的鼻咽癌稳定细胞株的建立和鉴定显示文摘目的:应用慢病毒介导的RNA干扰技术,建立稳定表达si Pin1的鼻咽癌细胞株。方法:将对照组病毒液lv-3和实验组病毒液si Pin1感染CNE2细胞,通过嘌呤霉素和绿色荧光检测筛选si Pin1稳定细胞株,在荧光显微镜下观察细胞的荧光表达,通过定量PCR和Western blot鉴定si Pin1细胞Pin1 mRNA和蛋白的表达。结果:筛选si Pin1稳定表达细胞株嘌呤霉素筛选浓度为1μg/ml,病毒感染后超过90%细胞发出绿色荧光,实验组si Pin1与对照组lv-3相比,Pin1 mRNA表达水平下降,Western blotting检测Pin1蛋白表达明显减少。结论:成功构建Pin1干扰的稳定表达鼻咽癌细胞株,为后续研究提供工具细胞。 | 陈华 黄国良 何志巍 | 2015 | 现代肿瘤医学2015，23，7： | 0 |
| 6 | High incidence of nasopharyngeal cancer: similarity for 60% of mitochondrial DNA signatures between the Bidayuhs of Borneo and the Bai-yue of Southern China显示文摘Populations in Southern China (Bai-yue) and Borneo (Bidayuh) with high incidence of nasopharyngeal cancer (NPC) share similar mitochondrial DNA signatures, supporting the hypothesis that these two populations may share the same genetic predisposition for NPC, which may have first appeared in a common ancestral reference population before the sea levels rose after the last ice age. | Joseph Wee Tam Cam Ha Susan Loong Chao-Nan Qian | 2012 | Chinese Journal of Cancer2012，31，9： | 0 |
| 7 | HLA-DRB1位点等位基因多态性与新疆汉族鼻咽癌的相关性研究显示文摘目的探讨新疆汉族人群HLA-DRB1位点基因多态性与鼻咽癌(nasopharyngeal carcinoma,NPC)遗传易感性的关系。方法应用聚合酶链反应/序列特异性引物(PCR-SSP)方法对50例鼻咽癌患者(NPC组)及43例正常体检者(对照组)进行HLA-DRB1位点基因分型,比较两组HLA-DRB1位点等位基因频率分布差异。结果 NPC组DRB1*1201较对照组降低(χ2=6.785,P=0.009,OR=0.319,CI=0.131~0.777),P值经Bonferroni校正后HLA-DRB1位点等位基因频率差异均无统计学意义(Pc>0.05)。结论新疆汉族人群HLA-DRB1位点基因多态性与鼻咽癌遗传易感性无相关性。 | 陈婷 吴冉 王若峥 | 2013 | 新疆医科大学学报2013，36，7： | 0 |
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