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| 1 | Short and long term fate of human AMSC subcutaneously injected in mice显示文摘AIM:To study the ability of human adipose-derived mesenchymal stem cells(AMSCs)to survive over the short and long term,their biodistribution and their biosafety in vivo in tumor-prone environments.METHODS:We subcutaneously injected human AMSCs from different human donors into immunodeficient SCID mice over both short-(2 and 4 mo)and long-(17 mo)term in young,and aged tumor-prone mice.Presence of human cells was studied by immunohistochemistry and polymerase chain reaction analysis in all organs of injected mice.RESULTS:Subcutaneously injected AMSCs did not form teratomas at any time point.They did not migrate but remained at the site of injection regardless of animal age,and did not fuse with host cells in any organ examined.AMSCs survived in vivo for at least 17 mo after injection,and differentiated into fibroblasts of the subdermic connective tissue and into mature adipocytes of fat tissue,exclusively at the site of injection.CONCLUSION:Our results support the assertion that AMSC may be safe candidates for therapy when injected subcutaneously because of their long term inability to form teratomas. | Pilar López-Iglesias Alejandro Blázquez-Martínez Jorge Fernández-Delgado Javier Regadera Manuel Nistal Maria P De Miguel | 2011 | World Journal of Stem Cells2011，3，6： | 5 |
| 2 | Neurobiology of disease in children: tourette syndrome显示文摘 | Maria BL | 2006 | J Child Neurol2006，21，8： | 1 |
| 3 | Clinical features and revised diagnostic critertia in Joubert syndrome显示文摘 | Maria BL Boltshauser E Palmer SC | 1999 | J Child Neurol1999，14，： | 1 |
| 4 | Magnetic resonance imaging features and classification of central nervous system malformations in Joubert syndrome显示文摘 | Quisling RG Barkovich AJ Maria BL | 1999 | J Child Neurol1999，14，： | 1 |
| 5 | Molar tooth signin Joubert syndrome: clinical, radiolgic, and pathologic sig-nificance显示文摘 | Maria BL Quisling RG Rosainz LG | 1999 | J Child Neurol1999，14，6： | 1 |
| 6 | Soil redistribution by terracing alleviates soil organic carbon losses caused by forest conversion to rubber plantation显示文摘 | Marleen de Blécourt Vera Maria H?nsel Rainer Brumme Marife D. Corre Edzo Veldkamp | 2014 | Forest Ecology and Management2014，，： | 1 |
| 7 | Chapter 38-Tuberous sclerosis显示文摘 | Curatolo P Maria BL | 2013 | Handb Clin Neurol2013，111，2： | 1 |
| 8 | Molar tooth sign in Jou- bert syndrome : clinical, radiologic, and pathologic significance 显示文摘 | Maria BL Quisling RG Rosainz LC | 1999 | J Child Neurol1999，14，： | 1 |
| 9 | Gene therapy for pediatric brain tumors显示文摘 | Maria BL Friedman T | 1997 | Semin Pediatr Neurol1997，4，4： | 1 |
| 10 | Sturge-Weber syndrome:a review显示文摘 | Vaslow DF Maria BL | 2004 | Pediatr Neurol2004，30，5： | 1 |
| 11 | Central nervous system structure and function in Sturge - Weber syndrome: evidence of neurologic and radiologic progression显示文摘 | Maria BL Neufeld JA Rosainz LC | 1998 | J Child Neurol1998，13，12： | 1 |
| 12 | Central nervous system structure and function in Sturge - Weber syndrome: evidence of neurologic and radiologic progression显示文摘 | Maria BL Neufeld JA Rosain ZLC | 1998 | J Child Neurol1998，13，12： | 1 |
| 13 | Fibrosis and heart failure 显示文摘 | Maria SA Frazier OH Maximilian BL | 2014 | Heart Fail Rev2014，19，2： | 1 |
| 14 | High prevalence of bihemispheric structural and functional defects in Sturge-Weber syndrome显示文摘 | Neufeld JA Rosainz LC | 1998 | J Child Neurol1998，13，12： | 1 |
| 15 | Sturge-Weber syndrome:a review显示文摘 | Thomas-Sohl KA Vaslow DF Maria BL | | 0，，05： | 1 |
| 16 | Sturge-Weber Syndrome:a review显示文摘 | Vaslow DF Maria BL | 2004 | Pediatr Neurol2004，30，： | 1 |
| 17 | Consensus statement on the surgicalmanagement of spasticity related to cerebral palsy显示文摘 | Boop FA Woo R Maria BL | 2008 | J Child Neu-ral2008，16，1： | 1 |
| 18 | Molar tooth sign in Jou-bert syndrome:clinical,radiologic and pathologic significance显示文摘 | Maria BL Quisling RG Rosainz LC | 1999 | JChild Neurol1999，14，6： | 1 |
| 19 | Quantitative as-sessment of brainstem development in Joubert syndrome and Dan-dy-walker syndrome显示文摘 | Maria BL Bozorgmanesh A Kimmel KN | 2001 | J Child Neurol2001，16，10： | 1 |
| 20 | Sturge-Weber syndrome : a review 显示文摘 | Thomas-Sohl KA Vaslow DF Maria BL | 2004 | Pediatr Neurol2004，30，5： | 1 |
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