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| 1 | Small intestinal bacterial overgrowth syndrome显示文摘Human intestinal microbiota create a complex polymi-crobial ecology. This is characterised by its high population density, wide diversity and complexity of interaction. Any dysbalance of this complex intestinal microbiome, both qualitative and quantitative, might have serious health consequence for a macro-organism, including small intestinal bacterial overgrowth syndrome (SIBO).SIBO is defined as an increase in the number and/or alteration in the type of bacteria in the upper gastro-intestinal tract. There are several endogenous defence mechanisms for preventing bacterial overgrowth: gastric acid secretion, intestinal motility, intact ileo-caecal valve, immunoglobulins within intestinal secretion and bacte-riostatic properties of pancreatic and biliary secretion. Aetiology of SIBO is usually complex, associated with disorders of protective antibacterial mechanisms (e.g. achlorhydria, pancreatic exocrine insuff iciency, immuno-deficiency syndromes), anatomical abnormalities (e.g. small intestinal obstruction, diverticula, f istulae, surgical blind loop, previous ileo-caecal resections) and/or motility disorders (e.g. scleroderma, autonomic neuropathy in diabetes mellitus, post-radiation enteropathy, small intestinal pseudo-obstruction). In some patients more than one factor may be involved. Symptoms related to SIBO are bloating, diarrhoea, malabsorption, weight loss and malnutrition. The gold standard for diagnosing SIBO is still microbial investigation of jejunal aspirates. Noninvasive hydrogen and methane breath tests are most commonly used for the diagnosis of SIBO using glucose or lactulose. Therapy for SIBO must be com-plex, addressing all causes, symptoms and complica-tions, and fully individualised. It should include treatment of the underlying disease, nutritional support and cyclical gastro-intestinal selective antibiotics. Prognosis is usually serious, determined mostly by the underlying disease that led to SIBO. | Jan Bures Jiri Cyrany Darina Kohoutova Miroslav Frstl Stanislav Rejchrt Jaroslav Kvetina Viktor Vorisek Marcela Kopacova | 2010 | World Journal of Gastroenterology2010，16，24： | 52 |
| 2 | Relationship between Fusobacterium nucleatum,inflammatory mediators and microRNAs in colorectal carcinogenesis显示文摘AIM To examine the effect of Fusobacterium nucleatum(F. nucleatum) on the microenvironment of colonic neoplasms and the expression of inflammatory mediators and microRNAs(miRNAs).METHODS Levels of F. nucleatum DNA, cytokine gene mRNA(TLR2, TLR4, NFKB1, TNF, IL1 B, IL6 and IL8), and potentially interacting miRNAs(miR-21-3p, miR-22-3p, mi R-28-5p, miR-34a-5p, miR-135b-5p) were measured by quantitative polymerase chain reaction(qPCR) TaqMan? assays in DNA and/or RNA extracted from the disease and adjacent normal fresh tissues of 27 colorectal adenoma(CRA) and 43 colorectal cancer(CRC) patients. KRAS mutations were detected by direct sequencing and microsatellite instability(MSI) status by multiplex PCR. Cytoscape v3.1.1 was used to construct the postulated miRNA:mRNA interaction network.RESULTS Overabundance of F. nucleatum in neoplastic tissue compared to matched normal tissue was detected in CRA(51.8%) and more markedly in CRC(72.1%). We observed significantly greater expression of TLR4, IL1 B, IL8, and miR-135 b in CRA lesions and TLR2, IL1 B, IL6, IL8, mi R-34 a and miR-135 b in CRC tumours compared to their respective normal tissues. Only two transcripts for miR-22 and miR-28 were exclusively downregulated in CRC tumour samples. The mRNA expression of IL1 B, IL6, IL8 and miR-22 was positively correlated with F. nucleatum quantification in CRC tumours. The mRNA expression of miR-135 b and TNF was inversely correlated. The miRNA:mRNA interaction network suggested that the upregulation of miR-34 a in CRC proceeds via a TLR2/TLR4-dependent response to F. nucleatum. Finally, KRAS mutations were more frequently observed in CRC samples infected with F. nucleatum and were associated with greater expression of miR-21 in CRA, while IL8 was upregulated in MSI-high CRC.CONCLUSION Our findings indicate that F. nucleatum is a risk factor for CRC by increasing the expression of inflammatory mediators through a possible mi RNA-mediated activation of TLR2/TLR4. | Marcela Alcantara Proenca Joice Matos Biselli Maysa Succi Fábio Eduardo Severino Gustavo Noriz Berardinelli Alaor Caetano Rui Manuel Reis David J Hughes Ana Elizabete Silva | 2018 | World Journal of Gastroenterology2018，24，47： | 15 |
| 3 | Intraoperative Radiation Therapy in the Treatment of PelvicGynecologic Malignancies: A Review of Fifteen Cases显示文摘 | Marcela G Del C James F | 2000 | Gynecologic Oncology2000，79，3： | 1 |
| 4 | The role of rhizobacteria in rice plants: Growth and mitigation of toxicity显示文摘Allelopathic compounds reduce the growth and productivity of upland rice plants, especially in consecutive plantations. The rhizobacteria Pseudomonas fluorescens BRM-32111 and Burkholderia pyrrocinia BRM-32113 have been recorded as growth promoters in rice. This study was developed to understand the effect of the application of rhizobacteria on upland rice plants in consecutive plantations. Experiments were conducted in a completely randomized design with four replications of four treatments: rice seed inoculated with P. fluorescens BRM-32111, rice seed inoculated with B. pyrrocinia BRM-32113(both sown on soil with rice residue), non-inoculated plants sown on soil with rice residue(control with residue(WR)), and non-inoculated plants on soil with no residue(NR). Roots and seedling growth were adversely affected by allelopathic compounds in control WR plants. Plants inoculated with rhizobacteria P. fluorescens BRM-32111 or B. pyrrocinia BRM-32113 induced an increase of 88% in biomass, 3% in the leaf area, 40% in length, 67% in root biomass, 21% in chlorophyll a, 53% in chlorophyll(a+b), 50% in rate of carbon assimilation(A), 227% in A/rubisco carboxylation efficiency(C_i) and 63% in water use efficiency(WUE) compared to control WR plants. These results indicate that rhizobacteria P. fluorescens BRM-32111 and B. pyrrocinia BRM-32113 increase the tolerance of rice plants to stress from allelochemicals. There are possible practical agricultural applications of these results for mitigating the effects of environmental allelochemistry on upland rice. | Marcela C F Rêgo Aline F Cardoso Thayná da C Ferreira Marta C C de Filippi Telma F V Batista Rafael G Viana Gisele B da Silva | 2018 | Journal of Integrative Agriculture2018，17，12： | 1 |
| 5 | Brewer's spent grain as raw material for lactic acid production by Lactobacillus delbrueckii 显示文摘 | Mussatto S I Marcela F Dragone G | 2007 | Biotechnology Letters2007，，12： | 1 |
| 6 | In vivo charaterization of the murine intranasal model fro assessing the immunogenicity of attenuated Salmonella enterica servar Typhi strains as live mucosal vaccines and as live vectors 显示文摘 | Pickett T Marcela F | 2000 | Infect Immunol2000，68，1： | 1 |
| 7 | Production, characterization and application of activated carbon from brewer's spent grain lignin显示文摘 | Solange I M Marcela F George J M R | 2010 | Bioresource Technology2010，101，： | 1 |
| 8 | In vivo charaterization of the murine intranasal model for assessing the immunogenicity of attenuated Salmonella enterica servar Typhi strains as live mucosal vaccines and as live vectors显示文摘 | Pickett T Marcela F | 2000 | Infect Immunol2000，68，1： | 1 |
| 9 | Dissolving pulp production from sugar cane bagasse显示文摘 | Marcela F A Jorge L C | 2014 | Industrial Crops and Products2014，53，： | 1 |
| 10 | Biological control by Tri- choderrna species of Fusarium solani causing peanut brown root rot under field conditions显示文摘 | Federico G R Maria M R Marcela F | 2007 | Crop Protection2007，26，4： | 1 |
| 11 | Evaluation of actinomycetes strains for key traits related with plant growth promotion and mycorrhiza helping activities 显示文摘 | MARCELA F - C ANGELICA Q CHRISTIAN D | 2010 | Applied Soil Ecology2010，45，3： | 1 |
| 12 | Red, green and blue (RGB) emission doped Y3Al5O12(YAG) phosphors prepared by non-hydrolytic sol-gel route 显示文摘 | PAULA F S PEREIRA MARCELA G | 2010 | J Lumin2010，130，3： | 1 |
| 13 | Validation of a chiral HPLC assay for (R) -salbutamol sulfate 显示文摘 | ALEJANDRA H CARLOS F MARCELA P | 2004 | J Pharm Biota Anal2004，34，1： | 1 |
| 14 | The effect of agitation speed,enzyme loading and substrate concentration on enzymatic hydrolysis of cellulose from brewer′s spent grain显示文摘 | MUSSATTO S I GIULIANO D MARCELA F | 2008 | Cellulose2008，15，7： | 1 |
| 15 | Selection of an extracellular esterase producing microorganism 显示文摘 | GUILLERMO R C ADRIAN O S MARCELA A F | 1992 | Journal of Industrial Microbiology1992，10，： | 1 |
| 16 | Communication between gastrointestinal bacteria and the nervous system显示文摘 | Javier A Bravo Marcela Julio-Pieper Paul Forsythe Wolfgang Kunze Timothy G Dinan John Bienenstock John F Cryan | 2012 | Current Opinion in Pharmacology2012，，： | 1 |
| 17 | Animal models paving the way for clinical trials of attenuated Salmonella enterica serovar Typhi live oral vaccines and live vectors显示文摘 | Marcela F Pasetti Myron M Levine Marcelo B Sztein | 2002 | Vaccine2002，，： | 1 |
| 18 | Bacillus amyloliquefaciens BNM122, a potential microbial bioeontrol agent applied on soybean seeds, causes a minor impact on rhizosphere and soil microbial communities 显示文摘 | OLGA S C MARCELA S M MARIA F B | 2009 | Applied Soil Ecology2009，41，2： | 1 |
| 19 | Communication between gastrointestinal bacteria and the nervous system显示文摘 | Javier A Bravo Marcela Julio-Pieper Paul Forsythe Wolfgang Kunze Timothy G Dinan John Bienenstock John F Cryan | 2012 | Current Opinion in Pharmacology2012，，6： | 1 |
| 20 | Validation ofa chiral HPLC assay for0)-salbutamol sulfate 显示文摘 | Alejandra H Carlos F Marcela P | 2004 | Pharmaceutical and Biomedical Analysis2004，34，1： | 1 |
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