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| 1 | 应用组织型纤溶酶原激活物行静脉溶栓治疗急性缺血性卒中的时间窗延长——美国心脏协会/美国卒中协会的科学建议显示文摘美国心脏协会卒中委员会发布了关于急性缺血性卒中的现行治疗指南,其中包括应用重组组织型纤溶酶原激活物(rt—PA)行静脉溶栓的建议。尽管该药对改善神经功能预后有一定的疗效,但由于患者通常在发病3h后方能到达医院,往往已经超过了用药的时间窗。因此,大部分缺血性卒中患者未能接受rt—PA治疗。目前研究认为,增加rt—PA治疗例数的最可能方法就是延长治疗时间窗。 | del Zoppo G J Saver J L Jauch E C Adams H P Jr. | 2009 | 中国脑血管病杂志2009，6，8： | 8 |
| 2 | Clinical significance of'anti-HBc alone'in human immunodeficiency virus-positive patients显示文摘AIM:To determine the prevalence and clinical relevance of isolated antibodies to hepatitis B core antigen as the only marker of infection('anti-HBc alone')among human immunodeficiency virus(HIV) type-1 infected patients.Occult hepatitis B infection frequency was also evaluated. METHODS:Three hundred and forty eight histories from 2388 HIV-positive patients were randomly reviewed.Patients with serological markers of hepatitis B virus(HBV)infection were classified into three groups:past hepatitis,'anti-HBc alone'and chronic hepatitis.Determination of DNA from HBV,and RNA and genotype from hepatitis C virus(HCV)were performed on'anti-HBc alone'patients. RESULTS:One hundred and eighty seven(53.7%) HIV-positive patients had markers of HBV infection: 118 past infection(63.1%),14 chronic hepatitis (7.5%)and 55'anti-HBc alone'(29.4%).Younger age[2.3-fold higher per every 10 years younger;95% confidence intervals(CI)1.33-4.00]and antibodies to HCV infection[odds ratio(OR)2.87;95%CI 1.10-7.48]were factors independently associated with the'anti-HBc alone'pattern.No differences in liver disease frequency were detected between both groups. Serum levels of anti-HBs were not associated with HCV infection(nor viral replication or HCV genotype),or with HIV replication or CD4 level.No'anti-HBc alone' patient tested positive for HBV DNA. CONCLUSION:'Anti-HBc alone'prevalence in HIVpositive patients was similar to previously reported data and was associated with a younger age and with antibodies to HCV infection.In clinical practice,HBV DNA determination should be performed only in those patients with clinical or analytical signs of liver injury. | M~aTeresa Pérez-Rodríguez Bernardo Sopea Manuel Crespo Alberto Rivera Teresa González del Blanco Antonio Ocampo César Martínez-Vázquez | 2009 | World Journal of Gastroenterology2009，15，10： | 2 |
| 3 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 4 | -592 and -1082 interleukin-10 polymorphisms in pulmonary tuberculosis with type 2 diabetes显示文摘Objective:To determine the polymorphisms of Interleukin-10(IL-10)(-592,-1082) in pulmonary tuberculosis(PTB)with and without type 2 diabetes(T2D).Methods:We studied a Mexican mestizo population of 37 patients with TB in remission(TBr) and 40 with active pulmonary TB (PTB),21 patients with TB + T2D.47 blood donors accepted,and 13 healthy health-care workers with tuberculin skin lest positive.Determination of IL-10 polymorphisms was performed by real-lime Polymerase chain reaction.Results:IL-10-592C/A presented in a greater proportion in healthy individuals than in patients with type 2 diabetes and TB in a not quite significant statistically manner.IL-10-1082A/A presented more frequently in the group of patients with both diseases,not being statistically significant in comparison with the group of healthy subjects. Conclusions:This study describes two important new findings.First,it reveals that the IL-10 (-592 A/A and -592 C/C) polymorphisms were found in a greater proportion in a group of patients with T2D and TB than in healthy subjects.Second,the study provides evidence that the(-1082 G/G) polymorphism presented with greater frequency in healthy individuals than in patients with both ol these diseases. | Guadalupe García-Elorriaga Leila Vera-Ramírez Guillermo del Rey-Pineda Csar Gonzlez-Bonilla | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，7： | 2 |
| 5 | Clinical history and new prognostic indicators in metachromatic leukodystrophy 显示文摘 | Del Carro U Bifffi A Boldoll C | 2004 | J Peripher Nerv Syst2004，9，： | 1 |
| 6 | Persistent pulmonary hypertension of the newborn: therapeutical approach 显示文摘 | Latini G Del Vecchio A De Felice C | 2008 | Mini Rev Med Chem2008，8，14： | 1 |
| 7 | Corticosteroids effectiveness in IgA nephropathy: long-term results of a randomized controlled trial显示文摘 | Pozzi C Andrulli S Del Vecchio L | 2004 | J Am Soc Nephrol2004，15，1： | 1 |
| 8 | 显示文摘 | del Valle J A Picasso A C Alvarez I | 1999 | Scripta Materialia1999，41，3： | 1 |
| 9 | Realization theorems for categories of graded module over semigroup- graded ring显示文摘 | Abrams G Menimi C Angel Del Rio | 1994 | CommAlgebra1994，22，13： | 1 |
| 10 | Size-dependent electron-electron interactions in metal nanoparticles 显示文摘 | VOISIN C CHRISTOFILOS D DEL FATTI N | 2000 | Phys Rev Lett2000，85，10： | 1 |
| 11 | Phosphorus removal by sands for use as media in subsurface flow constructed reed beds 显示文摘 | Arias C A Del Bubba M Brix H | 2001 | Water Res2001，35，5： | 1 |
| 12 | Amplitude reduction in visual event-related potentials as a function of sleep deprivation 显示文摘 | Corsi CM Arce C del Rio Portilla IY | 1999 | Sleep1999，22，1： | 1 |
| 13 | On-line preconcentration and speciation of arsenic by flow injection hydride generation atomic absorption spectrophotometry显示文摘 | NARCISE C I S COO L C DEL MUNDO F R | 2005 | Talanta2005，68，： | 1 |
| 14 | ADC measure-ments at low and high structure with b values:insight into normalbrain clinical DWI显示文摘 | Garcia Santos JM Ordonez C Torres del Rio S | 2008 | Magn Reson Imaging2008，26，1： | 1 |
| 15 | Multiaxial fatigue and failure analysis of helical compression springs 显示文摘 | Del LlanoVizcaya L RubioGonzalez C Mesmaeque G | 2006 | Engineering Fatigue Analy- sis2006，13，8： | 1 |
| 16 | The food contami- nant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression 显示文摘 | Pinton P Nougayrede J P Del rio J C | 2009 | Toxicol Appl Pharmacol2009，237，： | 1 |
| 17 | Laparoscopic testicular autotransplantation显示文摘 | Sánchez de Badajoz E Miguélez Lago C del Rosal Samaniego JM | 1992 | Arch Esp Urol1992，45，10： | 1 |
| 18 | 查看详情显示文摘 | del Olmo E Barboza B Ybarra M.I Lopez-Perez J.L Carron R Sevilla M.A Boselli C Feliciano A.S | | 0，，： | 1 |
| 19 | Ebola hemorrhagic fever in 2014: the tale of an evolving epidemic显示文摘 | Del Rio C Mehta AK Lyon GM | 2014 | Ann Intern Med2014，10，161： | 1 |
| 20 | Abnormal processing of the nociceptive input in Parkinson's disease: a study with CO2 laser evoked potentials 显示文摘 | Tinazzi M Del Vesco C Defazio G | 2008 | Pain2008，136，12： | 1 |
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