|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Blood glucose response after oral intake of lactulose in healthy volunteers:A randomized,controlled,cross-over study显示文摘AIM To investigate possible changes of blood glucose levels after oral intake of lactulose in healthy subjects.METHODS The study was performed as prospective, randomized, two-part study with 4-way cross-over design with n = 12 in each study arm. Capillary blood glucose levels were determined over a time period of 180 min after intake of a single dose of 10 g or 20 g lactulose provided as crystal or liquid formulation. During the manufacturing process of lactulose, impurities with sugars(e.g., lactose, fructose, galactose) occur. Water and 20 g glucose were used as control and reference. Because lactulose is used as a functional food ingredient, it may also be consumed by people with impaired glucose tolerance, including diabetics. Therefore, it is of interest to determine whether the described carbohydrate impurities may increase blood glucose levels after ingestion. RESULTS The blood glucose concentration-time curves after intake of 10 g lactulose, 20 g lactulose, and water were almost identical. None of the three applications showed any changes in blood glucose levels. After intake of 20 g glucose, blood glucose concentration increased by approximately 3 mmol/L(mean Cmax = 8.3 mmol/L), reaching maximum levels after approximately 30 min and returning to baseline within approximately 90 min, which was significantly different to the corresponding 20 g lactulose formulations(P < 0.0001). Comparing the two lactulose formulations, crystals and liquid, in the dosage of 10 g and 20 g, there was no difference in the blood glucose profile and calculated pharmacokinetic parameters despite the different amounts of carbohydrate impurities(1.5% for crystals and 26.45% for liquid). Anyhow, the absolute amount of single sugars was low with 0.3 g in crystals and 5.29 g in liquid formulation in the 20 g dosages. Lactulose was well tolerated by most volunteers, and only some reported mild to moderate mainly gastrointestinal side effects. CONCLUSION The unchanged blood glucose levels after lactulose intake in healthy subjects suggest its safe use in subjects with impaired glucose tolerance. | Jasmin Steudle Christiane Schon Manfred Wargenau Lioba Pauly Susann Schwejda-Güttes Barbara Gaigg Angelika Kuchinka-Koch John F Stover | 2018 | World Journal of Gastrointestinal Pharmacology and Therapeutics2018，9，3： | 4 |
| 2 | Current status of research and application in vascular stents显示文摘Cardiovascular diseases have been the leading cause of death in modern society.Using vascular stents to treat these coronary and peripheral artery diseases has been one of the most effective and rapidly adopted medical interventions.During the twenty-five years’development of vascular stents,revolutionary cardiovascular stents like drug eluting stents and endothelial progenitor cells capture stents have emerged.In this review,the evolution of vascular stents is summarized,aiming to provide a glimpse into the future of vascular stents.Advanced designs,focusing on the investigations of new substrates,new platforms,new drugs and new biomolecules are currently under evaluation with promising clinical studies.The concept of'time sequence functional stent'has been raised in this paper.It presents anti-proliferative properties in the first phase after implantation and subsequently support endothelialization.It also shows long-term inertness without release of toxic ions or toxic degradation products.The success of this concept is briefly presented with a clinical study in this model stents. | QI PengKai YANG Ying MAITZ F Manfred HUANG Nan | 2013 | Chinese Science Bulletin2013，58，35： | 3 |
| 3 | Salicylic Acid Alleviates the Cadmium Toxicity in Barley Saedlings显示文摘 | Ashraf M Iris F Manfred G | 2003 | Plant Physiology2003，132，： | 1 |
| 4 | New savings based algorithms for time come constrained pickup and delivery of full truckloads显示文摘 | Manfred Gronalt Richard F Hartl Marc Reimann | 2003 | European Journal of Operational Research2003，23，3： | 1 |
| 5 | NMR spectra of fluorinated carbohydrates显示文摘 | Manfred M Martin H Michael F | 2000 | Carbohyd Res2000，327，： | 1 |
| 6 | Salicylic Acid Alleviates the Cadmium Toxicity in Barley Seedlings显示文摘 | Ashraf M Iris F Manfred G | 2003 | Plant Physiol2003，132，： | 1 |
| 7 | In vitro measurement accuracy' of an electronic apex loeator in teeth with simulated apical root resorption 显示文摘 | Goldberg F Silvio ACD Manfre A | 2002 | J Endod2002，28，6： | 1 |
| 8 | In vitro measurement accuracy of an electronic apex locator in teeth with simulated apical root resorption显示文摘 | Goldberg F De Silvio AC Manfre S | 2002 | J Endod2002，28，6： | 1 |
| 9 | In vitro measurement accuracy of an electronic apex locator in teeth with simulate apical root resorption显示文摘 | Goldberq F De Silvio AC Manfre S | 2002 | Endod2002，28，6： | 1 |
| 10 | MR dacryocystography:comparison with dacryocystography and CT dacryocystography显示文摘 | Manfrè L de Maria M Todaro E Mangiameli A Ponte F Lagalla R | | 0，，06： | 1 |
| 11 | The paleozoic origin of eymatic lignin decomposition reconstructed from 31 fungal genomes显示文摘 | Dimitfios F Manfred B Robert R | 2012 | Science2012，338，29： | 1 |
| 12 | A novel synthesis of 2-deoxy-L-ribose 显示文摘 | Fabil F Manfred P S | 2000 | Tetrahedron: Asymmetry2000，11，： | 1 |
| 13 | In vitro measurement accuracy of an electronic apex locator in teeth with simulated apical root resorption显示文摘 | Goldberg F De Silvio AC Manfre S | 2002 | J Endod2002，28，6： | 1 |
| 14 | In vitro measurement accuracy of an electronic apex locator in teeth with simulated apical root resorption显示文摘 | Goldberg F De Silvio AC Manfre S | 2002 | J Endodont2002，28，6： | 1 |
| 15 | In situ conformational analysis of fibrinogen adsorbed on Si surfaces 显示文摘 | Sibel Tunc Manfred F Matiz Gerald Steiner | 2005 | Colloids and Surfaces B2005，42，： | 1 |
| 16 | Zika virus in Gabon(Central Africa)-2007:a new threat from Aedes albopictus?显示文摘 | Grard G Mélanie C Illich Manfred M DieudonnéN Statiana MO Davy J Didier F Christophe P Eric Maurice L | 2014 | PLoS Negl Trop Dis2014，8，2： | 1 |
| 17 | Energy requirements of Sydney households 显示文摘 | Manfred L Christopher D Barney F | 2004 | Ecological Economics2004，，49： | 1 |
| 18 | Interference control during recognition of facial affect enhances the processing of expression specific properties-an event-related fMRI study显示文摘 | Sascha F Thorsten F Manfred H | 2009 | Brain Res2009，1269，： | 1 |
| 19 | Allicin, a naturally occurring antibiotic from garlic, specifically inhibits acctyl CoA syn thetase显示文摘 | Manfred F Andrea F Hartnut K | 1990 | FEBSLetters1990，261，1： | 1 |
| 20 | In vitro measurement accuracy of an electronic apex locator in teeth with simulated apical root resorption显示文摘 | De Silvio AC Manfre S | 2002 | J Endod2002，28，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员