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| 1 | Inhibin/Activin信号对卵巢癌生长调控的初步研究显示文摘目的 :分析抑制素 (Inhibin)和激活素 (Activin)在卵巢癌上皮和间质中的表达 ,评估两种多肽信号对卵巢癌生长的调控作用 ,探讨卵巢癌发病机制。方法 :采用免疫组化法检测 10 2例卵巢癌上皮及间质中抑制素和激活素的表达。结果 :( 1)激活素在卵巢癌组织上皮和间质中的总阳性表达率显著高于抑制素 ( 79/ 2 0 4vs 5 2 / 2 0 4 ,P <0 .0 0 5 ) ;( 2 )卵巢癌上皮中激活素阳性表达率显著高于抑制素 ( 61/ 10 2vs 2 2 / 10 2 ,P <0 .0 0 5 ) ,而间质中抑制素阳性表达率显著高于激活素 ( 30 / 10 2vs 18/ 10 2 ,P <0 .0 5 ) ;( 3)高分化癌组织(G1、G2 )上皮中激活素阳性表达率显著低于低分化癌组织 (G3、G4 )上皮中激活素阳性表达率 ( 4 5 / 66vs 16/ 36,P <0 .0 0 5 )。结论 :抑制素和激活素在卵巢癌组织中的不平衡表达可能是卵巢癌发生、发展的原因之一 ;低分化癌组织较高分化癌组织合成更多的激活素 ,通过与受体结合 ,激活信号放大 。 | 张慧娟 刘伯宁 Sanjiv Manek TravidiS.Ganesan | 2003 | 现代妇产科进展2003，12，1： | 6 |
| 2 | 卵巢癌临床和生物学预测因子研究显示文摘目的 :研究影响卵巢癌患者预后的临床和生物学因素。方法 :回顾分析卵巢癌患者 88例的临床资料 ,并检测肿瘤组织上皮中血管内皮生长因子 (VEGF)和胸苷磷酸化酶 (TP)的表达及肿瘤间质内微血管密度 (MVD) ,应用Cox比例风险模型评估临床因素包括年龄、临床分期、组织学类型、细胞分化级别、术后残余癌灶及生物学因子 :VEGF、TP、MVD与总生存期 (OS)和无进展生存期 (PFS)之间的相关性。结果 :(1)患者的年龄、临床分期和术后癌灶大小显著影响其生存期的长短 ;(2 )Cox模型未发现VEGF、TP和MVD与OS和PFS之间的相关性 ;(3)低分化 (G3、G4 )肿瘤细胞中VEGF的表达显著高于高分化(G1、G2 )者。结论 :(1)年龄、临床分期和术后残余癌灶是三个独立的临床预测因子 ,表明早期诊断和适宜治疗极为重要 ;对老年患者应密切监护 ;(2 )低分化肿瘤细胞比高分化肿瘤细胞具有更恶的基因型和表现型 ,更易诱导间质内微血管生成 ,促进肿瘤的复发、转移和快速生长 。 | 张慧娟 Sanjiv Manek Han Chen Trivadi S.Ganesan | 2002 | 现代妇产科进展2002，11，4： | 5 |
| 3 | Investigation of the liquid recycle in the reactor cascade of an industrial scale ebullated bed hydrocracking unit显示文摘One of the commercial means to convert heavy oil residue is hydrocracking in an ebullated bed. The ebullated bed reactor includes a complex gas–liquid–solid backmixed system which attracts the attention of many scientists and research groups. This work is aimed at the calculation of the internal recycle flow rate and understanding its effect on other parameters of the ebullated bed. Measured data were collected from an industrial scale residual hydrocracking unit consisting of a cascade of three ebullated bed reactors. A simplified block model of the ebullated bed reactors was created in Aspen Plus and fed with measured data. For reaction yield calculation, a lumped kinetic model was used. The model was verified by comparing experimental and calculated distillation curves as well as the calculated and measured reactor inlet temperature. Influence of the feed rate on the recycle ratio(recycle to feed flow rate) was estimated. A relation between the recycle flow rate, pump pressure difference and catalyst inventory has been identified. The recycle ratio also affects the temperature gradient along the reactor cascade. Influence of the recycle ratio on the temperature gradient decreased with the cascade member order. | Eduard Manek Juma Haydary | 2019 | Chinese Journal of Chemical Engineering2019，27，2： | 2 |
| 4 | Linkage and association studies of the relationship between endometriosis and gene encoding the detoxification enzymes GSTM1,GSTT1 and CYP1A1显示文摘 | Hadfield RM Manek S Weeks DE | 2001 | Mol Hum Reprod2001，7，11： | 1 |
| 5 | Molecular genetic evidence that endometriosis is a precursor of ovarian cancer显示文摘 | Prowse AH Manek S Varma R | 2006 | Int J Cancer2006，119，3： | 1 |
| 6 | Inhibin expression in normal and pre-eclamptic placental tissue显示文摘 | Biddolph SC Ledger W Groome NP Manek S | 2000 | Int J Gynecol Pathol2000，19，3： | 1 |
| 7 | PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a non-estrogenic mechanism in the human endometrium 显示文摘 | Zhao Y Hague S Manek S el al | 1998 | Oncogone1998，16，3： | 1 |
| 8 | Molecular genetic evidencethat endometriosis is a precursor of ovarian cancer显示文摘 | Prowse AH Manek S Varma H | 2006 | Int J Canc-er2006，119，3： | 1 |
| 9 | High - power picosecond fiber amplifier based on nonlinear spectral compression 显示文摘 | Limpert J Deguil -Robin N Manek -Honinger I | 2005 | Opt Lett2005，30，7： | 1 |
| 10 | Tacrolimus (FK506) in the treatment of severe, refractory rheumatoid arthritis: initial experience in 12 patients显示文摘 | Gremillion RB Posever JO Manek N | 1999 | J Rheumatol1999，26，11： | 1 |
| 11 | The association of body mass index and osteoarthritis of the knee joint显示文摘 | Manek NJ Hart D Spector TD | | 0，，04： | 1 |
| 12 | Objective measures of laryngeal function after rennervation of the anterior and posterior recurrent laryngeal nerve branches显示文摘 | PETERSON K L ANDREW R MANEK A | 1998 | Laryngoscope1998，10，： | 1 |
| 13 | Epidemiology of back disorders:prevalence,risk factors,and prognosis显示文摘 | Manek Nisha J MacGregor AJ | 2005 | Rheumatology2005，17，2： | 1 |
| 14 | Endometrial atypical hyperplasia and subsequent diagnosis of endometrial cancer:a retrospective audit and literature review显示文摘 | Pennant S Manek S Kehoe S | 2008 | J Obstet Gynecol2008，28，6： | 1 |
| 15 | Pathology of ovarian cancers in BRCA1 and BRCA2 carriers 显示文摘 | Lakhani SR Manek S Penault-Llorca F | 2004 | Clin Cancer Res2004，10，7： | 1 |
| 16 | Born globals: How to reach new business space rapidly显示文摘 | Gabrielsson M and Kirpalani Manek V H | 2004 | International Business Review2004，13，5： | 1 |
| 17 | Pathology of warm ischaemia and reperfusion injury in adipomusculocuta- neous flap显示文摘 | Nishikawa H Manek S Barnett SS | 1993 | Int J Exp Path1993，74，： | 1 |
| 18 | Generation of a hollow laser beam for atom trapping using an axicon 显示文摘 | Manek I Ovehinnikov Y B Grimm R | 1998 | Opt Commun1998，147，： | 1 |
| 19 | Linkage and association studies of the relationship between endometriosis and genes encoding the detoxification enzymes GSTM1,GSTT1 and CYP1A1显示文摘 | Hadfield RM Manek S Weeks DE | 2001 | Mol Hum Reprod2001，7，： | 1 |
| 20 | Anaphylaxis following single component measles and rubella immunisation显示文摘 | Erlewyn-Lajeunesse M Manek R Lingam R | 2008 | Archives of Disease in Childhood2008，93，11： | 1 |
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