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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Surveillance for hepatocellular carcinoma in chronic liver disease:Evidence and controversies显示文摘Primary liver cancer is the sixth most common cancer in the world and the third cause of cancer-related death.Hepatocellular carcinoma(HCC)represents more than90%of primary liver cancers and generally occurs in patients with underlying chronic liver disease such as viral hepatitis,hemochromatosis,primary biliary cirrhosis and non-alcoholic steatohepatitis.Especially cirrhotic patients are at risk of HCC and regular surveillance could enable early detection and therapy,with potentially improved outcome.We here summarize existing evidence for surveillance including ultrasound,other radiological modalities and various serum biomarkers,and current international guideline recommendations for surveillance.Ultrasound andα-fetoprotein(alone or in combination)are most frequently used for surveillance,but their sensitivities and specificities are still far from perfect,and evidence for surveillance remains weak and controversial.Various other potential surveillance tools have been tested,including serum markers as des-carboxyprothrombin,lectin-boundα-fetoprotein,and(most recently)circulating TIE2-expressing monocytes,and radiological investigations such as computed tomographyscan or magnetic resonance imaging-scan.Although early results appear promising,these tools have generally been tested in diagnostic rather than surveillance setting,and in most cases,no detailed information is available on their cost-effectiveness.For the near future,it remains important to define those patients with highest risk of HCC and most benefit from surveillance,and to restrict surveillance to these categories. | Suzanne van Meer Robert A de Man Peter D Siersema Karel J van Erpecum | 2013 | World Journal of Gastroenterology2013，19，40： | 10 |
| 3 | Effect of salmeterol on resoiratory muscle activity during exercise in poorly reversible COPD 显示文摘 | Man WDC Mustfa N Nikoletou D | 2004 | Thorax2004，59，6： | 1 |
| 4 | Subsideband generation and modulational instability lasing in a fiber soliton laser显示文摘 | TAN D Y FLEMING S MAN W S | 2001 | JOSA B2001，18，10： | 1 |
| 5 | The effect test method and surface condition on pitting potential of single and duplex phase 304 L stainless steel 显示文摘 | Manning P E Duquette D Jand Savage W F | 1979 | Corroion1979，35，4： | 1 |
| 6 | The petrogenetic and metallogenetic significance of topaz granite from the SW England orefield 显示文摘 | Manning D A C Hill P I | 1990 | Geol Soc Am Spec Pap1990，246，： | 1 |
| 7 | Urinary leukotriene F4 levels during early and late asthmatic responses 显示文摘 | Manning PJ Rokach J Malo JL Ethier D Cartier A Girard Y Charleson S O'Byrne PM | 1990 | J Allergy Clin Immunol1990，86，2： | 1 |
| 8 | Comparison of geochemical indices used for the interpretation of palaeoredox conditions in ancient mudstones 显示文摘 | Jones B Manning D A C | 1994 | Chemical Geology1994，111，： | 1 |
| 9 | A control strategy for a robot with one articulate leg hopping on irregular terrain 显示文摘 | Vermeulen J Lefebor D De Man H | 2000 | Professional Engineering Publishing2000，，10： | 1 |
| 10 | Human rabies prevention-United States, 2008: recommendation of the Adviso- ry Committee on Immunization Practices显示文摘 | Manning SE Rupprecht CE Fishbein D | 2008 | MMWR Recomm Rep2008，57，3： | 1 |
| 11 | Nuclear receptor BgFTZ-F1 regulates molting and the timing of ecdysteroid production during nymphal development in the hemimetabolous insect Blattella germanica显示文摘 | Cruz J Nieva C Mané-Padrós D | | 0，，11： | 1 |
| 12 | Diversification and spectral tuning in marine proteorhodopsins显示文摘 | Man D Wang W Sabehi G | 2003 | European Molecular Biology Organization2003，22，8： | 1 |
| 13 | Surface morphology of a laser surface nitrided and etched Ti-6A1-4V alloy 显示文摘 | Man H C Zhao N Q Cui Z D | 2005 | Surfaceand Coatings Technology2005，192，： | 1 |
| 14 | Efficient algo- rithms for generalized stable marriage and roomates prob- lems 显示文摘 | FLEINER T IRVING R W MAN L D F | 2007 | Theoretical Computer Science2007，381，13： | 1 |
| 15 | AKT/PKB signaling: Navigating downstream 显示文摘 | MANNING B D CANTLEY L C | 2007 | Cell2007，129，7： | 1 |
| 16 | Determination of munition components in water by resin adsorption and high performance liquid chromatography-electrochemical detection显示文摘 | Manning D L Harvey R W | 1984 | J Chromatogr1984，302，： | 1 |
| 17 | AP-I and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis 显示文摘 | Han Z Boyle D L Manning A M | 1998 | Autoimmunity1998，28，4： | 1 |
| 18 | Occupational slip,trip, and fall- related injuries- can the contribution of slipperiness be isolated 显示文摘 | Courtney T K Sorock G S Manning D P | 2001 | Ergonomics2001，44，13： | 1 |
| 19 | Atril ejectionforce:a noninvasive assessment of atrial systolic function显示文摘 | Manning W J Silverman D I Katz S E | 1993 | J Am coll cardiol1993，22，1： | 1 |
| 20 | Expression of the apoptosis inhibitor,surviving,in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line显示文摘 | Gross man D MC Niff JM Li F | 1999 | Lab Invest1999，79，： | 1 |
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