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| 1 | Hepatitis B virus reactivation in hepatitis B virus surface antigen negative patients receiving immunosuppression: A hidden threat显示文摘AIM: To present the characteristics and the course of a series of anti- hepatitis B virus core antibody (HBc) antibody positive patients, who experienced hepatitis B virus (HBV) reactivation after immunosuppression. METHODS: We retrospectively evaluated in our tertiary centers the medical records of hepatitis B virus surface antigen (HBsAg) negative patients who suffered from HBV reactivation after chemotherapy or immunosuppression during a 3-year period (2009-2011). Accordingly, the clinical, laboratory and virological characteristics of 10 anti-HBc (+) anti-HBs (-)/HBsAg (-) and 4 anti-HBc (+)/antiHBs (+)/HBsAg (-) patients, who developed HBV reactivation after the initiation of chemotherapy or immunosuppressive treatment were analyzed. Quantitative determination of HBV DNA during reactivation was performed in all cases by a quantitative real time polymerase chain reaction kit (COBAS Taqman HBV Test; cut-off of detection: 6 IU/mL). RESULTS: Twelve out of 14 patients were males; median age 74.5 years. In 71.4% of them the primary diagnosis was hematologic malignancy; 78.6% had received rituximab (R) as part of the immunosuppressive regimen. The median time from last chemotherapy schedule till HBV reactivation for 10 out of 11 patients who received R was 3 (range 2-17) mo. Three patients (21.4%) deteriorated, manifesting ascites and hepatic encephalopathy and 2 (14.3%) of them died due to liver failure. CONCLUSION: HBsAg-negative anti-HBc antibody positive patients can develop HBV reactivation even 2 years after stopping immunosuppression, whereas prompt antiviral treatment on diagnosis of reactivation can be lifesaving. | Kalliopi Zachou Alexandros Sarantopoulos Nikolaos K Gatselis Themistoklis Vassiliadis Stella Gabeta Aggelos Stefos Asterios Saitis Panagiota Boura George N Dalekos | 2013 | World Journal of Hepatology2013，5，7： | 6 |
| 2 | Reversion of severe hepatopulmonary syndrome in a non cirrhotic patient after corticosteroid treatment for granulomatous hepatitis:A case report and review of the literature显示文摘肝肺症候群(HPS ) 包括肺内的脉管的膨胀的肝疾病,反常肺的煤气的交换和证据被定义为一个临床的三个一组。我们报导在最后年与疲劳,长持续的发烧,体重减轻,门静脉高血压的符号,肝脾大,胆汁郁积和进步 dyspnoea 介绍的 61 岁的男性。临床,实验室和组织检查所见证实了肉芽肿肝炎的诊断。由于肝的导致 granuloma 的门静脉高血压的 HPS 被证明是由提高对比的回响心动描记法证实了的病人的严重血氧不足的原因。在皮质甾治疗以后的 HPS 的回复被新提高对比的回响心动描记法与胆汁郁积的酶的正规化和病人的条件的改进一起证实。这是在有肝的肉芽肿的一个非肝脏硬化症的病人的 HPS 的完全的回复的第一个案例,显示在肝疾病的那肺内分流是功能的现象, HPS 能甚至在象在这种情况中的其他的肝参与被开发。 | Nikolaos Tzovaras Aggelos Stefos Sarah P Georgiadou Nikolaos Gatselis Georgia Papadamou Eirini Rigopoulou Maria Ioannou Ioannis Skoularigis Georgios N Dalekos | 2006 | World Journal of Gastroenterology2006，12，2： | 3 |
| 3 | Descriptive epidemiology ofchronic hepatitis B by using data from a hepatitis registry in CentralGreece 显示文摘 | Stefos A Gatselis N Zachou K | 2009 | Eur J Intern Med2009，20，1： | 1 |
| 4 | Emergence of Escherichia coli sequence type 410 (ST410) with KPC-2 β-lactamase显示文摘 | Angeliki Mavroidi Vivi Miriagou Ergina Malli Angelos Stefos George N. Dalekos Leonidas S. Tzouvelekis Efthymia Petinaki | 2011 | International Journal of Antimicrobial Agents2011，，3： | 1 |
| 5 | Phosphatidylethanolamine N-methyltransferase and choline dehydrogenase gene polymorphisms are associated with human sperm concentration显示文摘胆碱是在精子膜结构和流动性的规定的一个关键因素,并且这营养素在成熟和精子的使肥沃的能力起一个重要作用。phosphatidylethanolamine N-methyltransferase (PEMT ) 和胆碱脱氢酶(CHDH ) 的抄本,胆碱新陈代谢的二基本的酶,在人的睾丸被观察了,在这纸巾表明他们的基因表示。在现在的学习,我们探索了 PEMT 和 CHDH 基因变体的贡献到精子参数。200 oligospermic 和 250 个 normozoospermic 人被招募。DNA 从精子,和 PEMT − 被提取; 774G > C 和 CHDH + 432G > T 多型性是 genotyped。PEMT − 的遗传型分发; 774G > C 多型性没在 oligospermic 和 normozoospermic 人之间不同。相反,在 CHDH + 的情况中; 432G > T 多型性, oligospermic 人比 normozoospermic 人更经常介绍了 CHDH 432G/G 遗传型(62 %对 42 %, P< 0.001 ) 。 PEMT 774G/G 遗传型在 oligospermic 人与 PEMT 774G/C 和 774C/C 遗传型相比与更高的精子集中被联系( 12.5 ± ; 5.6 × ; 10 6精子 ml −1对 8.3 ± ; 5.2 × ; 10 6精子 ml −1, P< ; 0.002 )并且 normozoospermic 人( 81.5 ± ; 55.6 × ; 10 6对 68.1 ± ; 44.5 × ; 10 6精子 ml −1, P< ; 0.006 )。另外, CHDH 432G/G 遗传型在 oligospermic 与 CHDH 432G/T 和 432T/T 遗传型相比与更高的精子集中被联系( 11.8 ± ; 5.1 × ; 10 6对 7.8 ± ; 5.3 × ; 10 6精子 ml −1, P< ; 0.003 )并且 normozoospermic 人( 98.6 ± ; 62.2 × ; 10 6对 58.8 ± ; 33.6 × ; 10 6精子 ml −1, P< ; 0.001 )。在我们的系列, PEMT − 774G > C 和 CHDH + 432G > T 多型性与精子集中被联系。这发现在精子质量上建议这些基因的可能的影响。 | Leandros Lazaros Nectaria Xita Elissavet Hatzi Apostolos Kaponis Georgios Makrydimas Atsushi Takenaka Nikolaos Sofikitis Theodoros Stefos Konstantinos Zikopoulos Ioannis Georgiou | 2012 | Asian Journal of Andrology2012，14，5： | 1 |
| 6 | A case of partial mole and atypical type Ⅰ triploidy associated with severe HELLP syndrome at 18 weeks' gestation显示文摘 | Stefos T Plachouras N Mari G | | 0，，04： | 1 |
| 7 | Intramural pregnancy with negative maternal serum b-HCG显示文摘 | Dousias V Stefos T Chouliara S | 2003 | Eur J Obstet Gynecol Reprod Biol2003，111，1： | 1 |
| 8 | Correction of fetal anemia on the middle cerebral artery peak systolic velocity显示文摘 | Stefos T Cosmi E Detti L | 2002 | Obstetrics and Gynecology2002，99，2： | 1 |
| 9 | Intramural pregnancy with negative maternal serum β-HCG显示文摘 | Dousias V Stefos T Chouliara S | 2003 | Eur J Obstet Gynecol Reprod Biol2003，111，1： | 1 |
| 10 | Reproductive outcome in patients treated by oral methotrexate or laparoscopic salpingotomyfor the management of tubal ectopic pregnancy显示文摘 | Dalkalitsis N Stefos T Kaponis A | 2006 | Clin Exp ObstetGynecol2006，33，2： | 1 |
| 11 | Routinc obstetrical ultrasound at 18-22 weeks:our experience on 7,236 fetuses显示文摘 | Stefos T Plachouras N Sotiriadis A | | 0，，02： | 1 |
| 12 | Spontaneous spondy- lodiscitis: presentation, risk factors, diagnosis, management, and outcome显示文摘 | Kapsalaki E Gatselis N Stefos A | 2009 | Int J Infect Dis2009，13，5： | 1 |
| 13 | Intramural pregnancy with negative maternal serum β-hCG 显示文摘 | Dousias V Stefos T Chouliara S | 2003 | Eur J Obstet Oynecol Reprod Biol2003，111，1： | 1 |
| 14 | Fibrinolytic defects and recurrent miscarriage:a systematic review and metaanalysis显示文摘 | Sotiriadis A Makrigiannakis A Stefos T | 2007 | Obstet Gynecol2007，109，5： | 1 |
| 15 | Intramual pregnancy with negative oatmeal serum β-HCG显示文摘 | Dousias V stefos T chouliara S | | 0，，01： | 1 |
| 16 | Intramural preg-nancy with negative maternal serumβ-HCG显示文摘 | Dousias V Stefos T Chouliara S | 2003 | Eur JObstet Gynecol and Reprod Biol2003，111，1： | 1 |
| 17 | Repductive outcome in patients treated by oral methotrexatelaparoscopic salpingotomy for the management of tubal etopic pregnancy显示文摘 | Dalkalitsis N Stefos T Kaponis A | 2006 | Clin Exp Obstet Gynecol2006，33，2： | 1 |
| 18 | Routine obstetrical ultrasound at 18-22 weeks: our experience on 7,236 fetuses显示文摘 | Stefos T Plachouras N Sotiriadis A | 1999 | J Matern Fetal Med1999，8，2： | 1 |
| 19 | Reproductive outcome in patients treated by oral methotrexate or laparoscopic salpingotomy for the management of tubal ectopic pregnancy显示文摘 | Dalkalitsis N Stefos T Kaponis A | 2006 | Clin Exper Obste Gynecol2006，33，2： | 1 |
| 20 | Neuroendocrine and clinical characteristics of major depressed patients exhibiting sleep-onset REM显示文摘 | Van VC Stefos G | 1998 | Biol Psychiatry1998，43，： | 1 |
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