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| 1 | Presepsin teardown- pitfalls of biomarkers in the diagnosis and prognosis of bacterial infection in cirrhosis显示文摘AIM To evaluate the diagnostic and prognostic value of presepsin in cirrhosis-associated bacterial infections. METHODS Two hundred and sixteen patients with cirrhosis were enrolled. At admission, the presence of bacterial infections and level of plasma presepsin, serum C-reactive protein(CRP) and procalcitonin(PCT) were evaluated. Patients were followed for three months to assess the possible association between presepsin level and short-term mortality.RESULTS Present 34.7 of patients had bacterial infection. Presepsin levels were significantly higher in patients with infection than without(median, 1002 pg/m L vs 477 pg/m L, P < 0.001), increasing with the severity of infection [organ failure(OF): Yes vs No, 2358 pg/m L vs 710 pg/m L, P < 0.001]. Diagnostic accuracy of presepsin for severe infections was similar to PCT and superior to CRP(AUC-ROC: 0.85, 0.85 and 0.66, respectively, P = NS for presepsin vs PCT and P < 0.01 for presepsin vs CRP). At the optimal cut-off value of presepsin > 1206 pg/m L sensitivity, specificity, positive predictive values and negative predictive values were as follows: 87.5%, 74.5%, 61.8% and 92.7%. The accuracy of presepsin, however, decreased in advanced stage of the disease or in the presence of renal failure, most probably because of the significantly elevated presepsin levels in non-infected patients. 28-d mortality rate was higher among patients with > 1277 pg/m L compared to those with ≤ 1277 pg/m L(46.9% vs 11.6%, P < 0.001). In a binary logistic regression analysis, however, only PCT(OR = 1.81, 95%CI: 1.09-3.01, P = 0.022) but neither presepsin nor CRP were independent risk factor for 28-d mortality after adjusting with MELD score and leukocyte count.CONCLUSION Presepsin is a valuable new biomarker for defining severe infections in cirrhosis, proving same efficacy as PCT. However, it is not a useful marker of short-term mortality. | Maria Papp Tamas Tornai Zsuzsanna Vitalis Istvan Tornai David Tornai Tamas Dinya Andrea Sumegi Peter Antal-Szalmas | 2016 | World Journal of Gastroenterology2016，22，41： | 9 |
| 2 | mRNA expression, functional profiling and multivariate classification of colon biopsy specimen by cDNA overall glass microarray显示文摘AIM: To understand the local pathophysiological altera- tions and gene ontology-based functional classification of colonic biopsies into inflammatory and neoplastic dis- eases. METHODS: Total RNA was extracted from frozen biop- sies and amplified by T7-method. Expression profile was evaluated by Atlas Glass 1K microarrays. After microar- ray quality control, applicable data were available from 10 adenomas, 6 colorectal adenocarcinomas (CRCs), and 6 inflammatory bowel diseases (IBDs). Multivariate statistical and cell functional analyses were performed. Real-time RT-PCR and immunohistochemistry were used for validation. RESULTS: Discriminant analysis of selected genes, could correctly reclassify all 22 samples using 4 parameters (heat shock transcription factor-1, bystin-like, calgranu- lin-A, TRAIL receptor 3). IBD samples were characterized by overregulated chemokine (C-X-C motif) ligand 13, replication protein A1, E74-like factor 2 and downregu- lated TNF receptor-associated factor 6, BCL2-interacting killer genes. In adenomas upregulation of TNF receptor- associated factor 6, replication protein A1, E74-like factor 2 and underexpression of BCL2-associated X protein, cal- granulin-A genes were found. CRC cases had significantly increased epidermal growth factor receptor, topoisomer- ase-1, v-jun, TNF receptor-associated factor 6 and TRAIL receptor 3, and decreased RAD51 and RAD52 DNA repair gene, protein phosphatase-2A and BCL2-interacting killer mRNA levels. Epidermal growth factor receptor RT-PCR and immunohistochemistry, topoisomerase-1 RT-PCRconfirmed the chip results. CONCLUSION: Different histological alterations can be reclassified by functional, multivariate analysis using cDNA microarrays. Further studies with expanded sample number are needed for subclassification of pathological alterations. | Orsolya Galamb Ferenc Sipos Elek Dinya Sandor Spisak Zsolt Tulassay Bela Molnar | 2006 | World Journal of Gastroenterology2006，12，43： | 2 |
| 3 | Recovery of motor disability and spasticity in post-stroke after repetitive transcranial magnetic stimulation (rTMS)显示文摘 | Mally J Dinya E | | 0，，04： | 1 |
| 4 | Malignancies after renal transplantation during 33 years at a single center显示文摘 | Gyula Végs? Maria Tóth Márta Hídvégi éva Toronyi Robert Mlanger Elek Dinya András Tóth Ferenc Perner Jen? Járay | 2007 | Pathology & Oncology Research2007，，1： | 1 |
| 5 | Recovery of motor disability and spasticity in post stroke after repetitive transcranial magnetic stimulation (rTMS)显示文摘 | Mdlly J Dinya E | 2008 | Brain Res Bull2008，76，4： | 1 |
| 6 | Safety and efficacy of combined ezetimibe/ simvastatin treatment and simvastatin monotherapy in patients with non- alcoholic fatty liver disease显示文摘 | Abel T Feher J Dinya E | 2009 | Med Sci Monit2009，15，12： | 1 |
| 7 | Efficacy and safety of ezetimibe/simvastatin combination therapy in patients with type 2 diabetes and nonalcoholic fatty liver disease显示文摘 | Abel T Fehér J Dinya E | | 0，，21： | 1 |
| 8 | Risk status of patients with peripheral arterial disease (PAD)显示文摘 | JASSO I LANDI A DINYA E | 2007 | Orv Hetil2007，148，52： | 1 |
| 9 | Occurrence of oral leukoplakia and lichen planus in diabetes mellitus显示文摘 | Albrecht M Banoczy J Dinya E | | 0，，： | 1 |
| 10 | Structure elucidation of the antibiotic desertomycin through the use of new two-dimensional NMR techniques 显示文摘 | Bax A Aszalos A Dinya Z | 1986 | J Am Chem Soc1986，108，： | 1 |
| 11 | Functional mRNA expression analysis and classification of colonic biopsy samples using overall cDNA microarray technique显示文摘 | Galamb O Sipos F Dinya E | 2008 | Orv Hetil2008，149，5： | 1 |
| 12 | Occurrence of oral leukoplakia and lichen planus in diabetes mellitus显示文摘 | Albrecht M Banoczy J Dinya E | 1992 | J Oral Pathol Med1992，21，8： | 1 |
| 13 | Photodegradation study for accessing the environmental fates of some triazine-, urea-, thiolcarbamate-type herbicides 显示文摘 | Lanyi K Dinya Z | 2005 | Microchem J2005，80，1： | 1 |
| 14 | Recovery of motor disability and spasticity in post-stroke after repetitive transcranial magnetic stimulation (rTMS)显示文摘 | Mally J Dinya E | 2008 | Brain Res Bull2008，76，： | 1 |
| 15 | Photodegradation study of some triazine-type herbicides显示文摘 | Lányi Katalin Dinya Zoltán | 2003 | Microchemical Journal2003，75，1： | 1 |
| 16 | Flavonoid content and antioxidant activ- ity of vegetables from Indonesia 显示文摘 | Nufi A Ratna B Dinya S | 2010 | Food Chem2010，121，4： | 1 |
| 17 | Efficacy and safety of czctimibe/simvastafin combination therapy in patients with type 2 diabetes and nonalcoholic fatty liver disease显示文摘 | Abel T Feher J Dinya E | 2009 | Orv Hctil2009，150，21： | 1 |
| 18 | Recovery of motor disability and spasticity in poststroke after repetitive transcranial magnetic stimulation (rT- MS)显示文摘 | Mdlly J Dinya E | 2008 | Brain Res Bull2008，76，4： | 1 |
| 19 | LC-SSI-MS techniques as efficient tools for characterization of nonvolatile phenolic compounds of a special hungarian wine 显示文摘 | Kovács Z Dinya Z Antus S | 2004 | Chromatographic Sci Mar2004，42，3： | 1 |
| 20 | Recovery of motor disability and spasticity in post-stroke after repetitive transcranial magnetic stimulation(rTMS)显示文摘 | Mally J Dinya E | | 0，，04： | 1 |
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