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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Modelling the coordination of the controls of stomatal aperture,transpiration,leaf growth,and abscisic acid:update and extension of the TardieuDavies model显示文摘 | TARDIEU F SIMONNEAU T PARENT B | 2015 | Journal of Experimental Botany2015，66，8： | 1 |
| 3 | Contrast radiology, computed tomography and ultrasonography in detecting internal fistulas and intra-abdominal abscesses in Crohn's disease: a prospective comparative study显示文摘 | Maconi G Sampietro GM Parente F | 2003 | Am J Gastroenterol2003，98，： | 1 |
| 4 | A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep vein thrombosis显示文摘 | Decousus H Leizorovicz A Parent F | 1998 | N Engl J Med1998，33，： | 1 |
| 5 | Use of maximum entropy spectral analysis to improve ship detection by the over-the-horizon radar显示文摘 | Bourdillon A Gouthier F Parent J | 1987 | Radio Science1987，22，2： | 1 |
| 6 | A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep- vein thrombosis 显示文摘 | DECOUSUS H LEIZOROVICZ A PARENT F | 2001 | N Engl J Med2001，338，： | 1 |
| 7 | Double-bl-ind randomized,multicenterstudy comparing aluminium phosphate gel with ranitidine in the short-term treat-ment ofduodenal ulcer显示文摘 | Parente F Bianchi Porro G Canali A | 1995 | Hepatogastroenterology1995，42，2： | 1 |
| 8 | Fertilization strategies for lowering nitrate contents in leafy vegetables: Chicory and rocket salad cases 显示文摘 | Stantamaria P Elia Parente A Serio F | 1998 | Journal of plant nutrition1998，21，9： | 1 |
| 9 | Numerical models for 2D free boundary analysis of groundwater in slopes stabilized by drain trenches显示文摘 | DACUNTO B PARENTE F URCIUOLI G | 2007 | Computers & Mathematics with Applications2007，53，10： | 1 |
| 10 | High prevalence of detectable deep venous thrombosis in patients with acute pulmonary embolism显示文摘 | Girard P Musset D Parent F | 1999 | Chest1999，116，4： | 1 |
| 11 | New brace de- sign combining CAD/ CAM and biomechanical simulation for the treatment of adolescent idiopathic scoliosis显示文摘 | Desbiens-Blais F Clin J Parent S9 | 2012 | Clin Biomech(Bristol Avon)2012，27，10： | 1 |
| 12 | Sulfuration and re- version reactions of brominated poly (isobutylene-co-isoprene) 显示文摘 | Parent J S White G D F Thorn D J | 2003 | Journal of Polymer Science ( part A ) : Polymer Chemistry2003，41，13： | 1 |
| 13 | 肺动脉高压启动治疗后血流动力学指标的预后价值显示文摘血流动力学指标,如心脏指数和右心房压力(right atrial pressure,RAP)与患者确诊肺动脉高压时的生存率持续相关。近期研究表明,肺动脉顺应性(pulmon aryarterial compliance,Pea)也可能预测肺动脉高压的预后。而在治疗开始之后测定的血流动力学指标对预后的价值还未确定。 | 黄洁 叶鹏 Weatherald J Boucly A Chemla D Savale L Peng M Jevnikar M Ja?s X Taniguchi Y O'Connell C Parent F Sattler C Hervé P Simonneau G Montani D Humbert M Adir Y Sitbon O | 2017 | 中华高血压杂志2017，25，11： | 1 |
| 14 | On the estimation of quasi-instantaneous frequency modulation of HF signals propagated through the ionosphere显示文摘 | GAUTHIER F BOURDILLON A PARENT J | 1990 | IEEE Trans Antennas Propagat1990，38，3： | 1 |
| 15 | Saturator analysis for an evaporative gas turbine cycle 显示文摘 | PARENTE J TRAVERSO A MASSARDO A F | 2003 | Applied Thermal Engineering2003，23，： | 1 |
| 16 | A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis显示文摘 | Decousus H Leizorovicz A Parent F | 1998 | N Engl J Med1998，338，7： | 1 |
| 17 | Contrast radiology,computed tomography and ultrasonography in detecting internal fistulas and intraabdominal abbcesses in Crohn's disease:a prospective comparative study显示文摘 | Sampietro GM Parente F | 2003 | Am J Gastroenterol2003，98，7： | 1 |
| 18 | Saturator analysis for an evaporative gas turbine cycle显示文摘 | PARENTE J O S TRAVERSO A MASSARDO A F | 2003 | Applied Thermal Engineering2003，23，10： | 1 |
| 19 | Diagnostic strategy for patients with suspected pulmonary embolism:a prospective multicentre outcome study 显示文摘 | Musset D Parent F Meyer G | 2002 | Lancet2002，360，： | 1 |
| 20 | Optimal duration of chemotherapy in non-small-cell lung cancer:multicenter,randomized,prospective clinical trial comparing 4 vs 6 cycles of carboplatin and gerncitabine显示文摘 | Barata F Parente B Teixeira E | | 0，，08： | 1 |
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