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| 1 | Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients显示文摘Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome.In clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to stroke.So far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS evaluation.Thus,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not reveal.Methods Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE trial.The NIHSS domains were grouped into six categories using two schemes.LSM was conducted for each category of the two groupings and the total NIHSS score.Results Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised assessments.Conclusion These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging. | Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal Sean P Dukelow Nils Daniel Forkert | 2022 | Stroke & Vascular Neurology2022，7，2： | 7 |
| 2 | Haploid culture and uv mutagenesis in rapid - cycling Brassica napus for the generation of resistance to chlorsulfuron and Alternaria brassicicola显示文摘 | Ahmad L Day J P MacDonald M V | 1991 | Annals of Botany1991，67，： | 2 |
| 3 | Role of the vitamin D receptor in hair follicle biology显示文摘 | DEMAY M B MACDONALD P N SKORIJA K | 2007 | J Steroid Biochem Mol Biol2007，103，35： | 1 |
| 4 | Strategic management of technical functions 显示文摘 | Adler P S McDonald D W MacDonald F | 1992 | Sloan Management Review1992，33，2： | 1 |
| 5 | A case-control family history study of autism显示文摘 | Bohon P Macdonald H Pickles A | 1994 | J Child Psychol Psychiatry1994，35，5： | 1 |
| 6 | A review of world wide contamination of cereal grains and animal feed with fusarium mycotoxins 显示文摘 | Plcinta C M Mello J P E Macdonald A M C | 1999 | J Animal feed science and technology1999，78，： | 1 |
| 7 | Marked redution of cerebral vasospasm with lumbar drainage of cerebrospinal fluid after subarachnoid hemorrhage 显示文摘 | Klimo P Kestle JR MacDonald J D | 2004 | J Neurosurgery2004，100，2： | 1 |
| 8 | Endothelin-1 gene expression and biosynthesis in human endometrial HEC-IA cancer cells 显示文摘 | Economos K Macdonald P C Casey M L | 1992 | Caner Res1992，52，3： | 1 |
| 9 | Tacrolimus(FK506)increases neuronal expression of GAP-43 andiroves functional recovery after spinal cord injury in rats显示文摘 | Madsen JR MacDonald P Irwin N | 1998 | Exp Neurol1998，154，2： | 1 |
| 10 | The unexpected movement of the HIV epidemic in the Southeastern United States: transmission among college students 显示文摘 | Hightow L Macdonald P Pilcher C | 2005 | J Acquir Immune Defic Syndr2005，38，5： | 1 |
| 11 | Cerebral vasospasm: looking beyond vasoconstriction 显示文摘 | Hansen-Schwartz J Vajkoczy P Macdonald RL | 2007 | Pharmacological Sciences2007，28，6： | 1 |
| 12 | Glucocorticoids and serotonin alter glucocorticoid receptor mRNA levels in fetal guinea-pig hippocampal neurons,in vitro显示文摘 | Erdeljan P Andrews MH MacDonald JF | | 0，，07： | 1 |
| 13 | Unused fertilizer nitrogen in arable soils:Its contribution to nitrate leaching显示文摘 | MacDonald A J PowlsonD S Poulton P R | 1989 | Journal of the Science of Food and Agriculture1989，46，4： | 1 |
| 14 | Baseline predic, tors of tolerability to carvedilol in patients with chronic heart failure显示文摘 | KRUM H NINIO D MacDONALD P | 2000 | Heart2000，849，6： | 1 |
| 15 | Development of a novel method of tube bending using finite element simulation显示文摘 | Baudin S Ray P MacDonald B J | 2004 | Journal of Materials Processing Technology2004，，： | 1 |
| 16 | Neutrophil proteas inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain显示文摘 | Saadoun S Waters P MacDonald C | 2012 | Ann Neurol2012，71，3： | 1 |
| 17 | The role of b-type natriuretic peptide in heart failure management显示文摘 | Newton PJ Betihavas V Macdonald P | 2009 | Aust Crit Care2009，8，22： | 1 |
| 18 | Apoptosis as a mechanism for cell surface expression of the autoantigen pyruvate dehydrogenase complex显示文摘 | Macdonald P Palmer J Kirby JA | 2004 | Clin Exp Immunol2004，136，3： | 1 |
| 19 | Members of a new family of DNA binding proteins bind to a conserved cis-element in the promoters of a Amy2 genes显示文摘 | Rushton P J Macdonald H Huttly A K | 1995 | Plant Mol Biol1995，29，： | 1 |
| 20 | pH Measurements of High Temperature Aqueous Environments with Stabilized-Zirconia Membranes 显示文摘 | Hettiarachchi S Kedzierzawski P Macdonald D D | 1985 | J Electrochem Soc1985，132，8： | 1 |
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