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| 1 | Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients显示文摘Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome.In clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to stroke.So far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS evaluation.Thus,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not reveal.Methods Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE trial.The NIHSS domains were grouped into six categories using two schemes.LSM was conducted for each category of the two groupings and the total NIHSS score.Results Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised assessments.Conclusion These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging. | Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal Sean P Dukelow Nils Daniel Forkert | 2022 | Stroke & Vascular Neurology2022，7，2： | 7 |
| 2 | Haploid culture and uv mutagenesis in rapid - cycling Brassica napus for the generation of resistance to chlorsulfuron and Alternaria brassicicola显示文摘 | Ahmad L Day J P MacDonald M V | 1991 | Annals of Botany1991，67，： | 2 |
| 3 | Role of the vitamin D receptor in hair follicle biology显示文摘 | DEMAY M B MACDONALD P N SKORIJA K | 2007 | J Steroid Biochem Mol Biol2007，103，35： | 1 |
| 4 | A review of world wide contamination of cereal grains and animal feed with fusarium mycotoxins 显示文摘 | Plcinta C M Mello J P E Macdonald A M C | 1999 | J Animal feed science and technology1999，78，： | 1 |
| 5 | Endothelin-1 gene expression and biosynthesis in human endometrial HEC-IA cancer cells 显示文摘 | Economos K Macdonald P C Casey M L | 1992 | Caner Res1992，52，3： | 1 |
| 6 | Laser capture microdissection (LCM)and expression analyses of Gtycine max (soybean) syncytium containing root regions formed by the plant pathogen Heterodera glycines ( soybean cyst nematode) 显示文摘 | KLINK V P ALKHAROUF N MACDONALD M | 2005 | Plant Molecular Biology2005，59，6： | 1 |
| 7 | Laser capture microdissection (LCM) and comparative microarray expression analysis of syncytial cells isolated from incompatible and compatible soybean (Glycine max) roots infected by soybean cyst nematode (Heterodera glycines)显示文摘 | Klink V P Overall C C Alkharouf N MacDonald M H Matthews B F | | 0，，06： | 1 |
| 8 | Creation and manipulation of three-dimensional optically trapped structures显示文摘 | MacDonald M P Paterson L Volke-Sepulveda K | 2002 | Science2002，296，5570： | 1 |
| 9 | Aldosterone to renin ratio as a determinant of exercise blood pressure response in hypertensive patients显示文摘 | LIM P O DONNAN P T MACDONALD T M | 2001 | J Hum Hypertens2001，15，： | 1 |
| 10 | Mycotoxin pro-duction in a carbendazim-resistant strain of fusarium sporotri-chioides 显示文摘 | DMELLO J P MACDONALD A M BRIERE L | 2000 | Mycotoxin Research2000，16，2： | 1 |
| 11 | Phrasal Ordering Constraints in Sentence Production:Phrase Length and Verb Disposition in Heavy-NP Shift显示文摘 | STALLINGS L M MACDONALD M C O' SEAGHDHA P | | 0，，39： | 1 |
| 12 | A review ofworldwide contamination of cereal grains and animal feed withFusarium mycotoxins显示文摘 | Placinta C M D' Mello J P F Macdonald A M C | 1999 | Animal Feed Science and Technology1999，78，12： | 1 |
| 13 | Physiological adaptations to low-volume,high-intensity interval training in health and disease显示文摘 | GIBALA M J LITTLE J P MACDONALD M J | 2012 | J Physiol2012，590，5： | 1 |
| 14 | Laser capture microdissection (LCM) and expression analyses of Glycine max (soybean) syncytium containing root regions formed by the plant pathogen Heterodera glycines (soybean cyst nematode)显示文摘 | Klink V P Alkharout N MacDonald M Matthews B | | 0，，： | 1 |
| 15 | Microfluidic sorting in an optical lattice显示文摘 | MacDonald M P Spalding G C Dholakia K | 2003 | Nature2003，426，： | 1 |
| 16 | , Volke-Sepulveda K, Arlt J, Sibbert W,Dholakia K, Scienee显示文摘 | MacDonald M P Paterson I | 2002 | 2962002，，： | 1 |
| 17 | Mycotoxins显示文摘 | MELLO J P F MACDONALD A M C | 1997 | Animal Feed Science Technology1997，69，： | 1 |
| 18 | Organ preservation显示文摘 | Hicks M Hing A Gao L Ryan J Macdonald P S | 2006 | Methods Mol Biol2006，333，： | 1 |
| 19 | Improved endothelial cell adhesion and proliferation on patterned titanium surfaces with rationally designed, micrometer to nanometer features显示文摘 | LU J RAO M P MACDONALD N C | 2008 | Aeta Biomaterialia2008，4，1： | 1 |
| 20 | Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy显示文摘 | Naumov G N MacDonald I C Weinmeister P M | 2002 | Cancer Res2002，62，7： | 1 |
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