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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Anaerobic digestion of organicsolid wastes:Anoverview of research achievements and perspectives显示文摘 | Alvarez J M Macés L P | | 0，，74： | 1 |
| 3 | Deletion of dentin matrix protein-1 leads to a partpal failure of maturation of pre- dentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development 显示文摘 | YE L MAC DOUGALL M ZHANG S | 2004 | Biol Chem2004，279，18： | 1 |
| 4 | Risk of Liver Decompensation Among HIV/Hepatitis C Virus–Coinfected Individuals With Advanced Fibrosis: Implications for the Timing of Therapy显示文摘 | Juan Macías Manuel Márquez Francisco Téllez Dolores Merino Patricia Jiménez-Aguilar Luis F. López-Cortés Enrique Ortega Miguel A. von Wichmann Antonio Rivero María Mancebo Jesús Santos Montserrat Pérez-Pérez Ignacio Suárez-Lozano Alberto Romero-Palacios A | 2013 | Clinical Infectious Diseases2013，，10： | 1 |
| 5 | Statistical methods for dissecting triploid endosperm traits using molecular markers: an autogamous model显示文摘 | WU R L MAC X MARIA G M | 2002 | Genetics2002，162，： | 1 |
| 6 | Fiber inclination model of three dimensional textile structural composites显示文摘 | YANG J M MAC L CHOU T W | 1986 | Journal of Composite Materials1986，20，5： | 1 |
| 7 | Acupuncture on the day of embryo transfer significantly improves the reproductive outcome in infertile women:A prospective,randomized trial显示文摘 | Westergaard L G Mac Q Krogslund M | 2006 | Fertility and Sterility2006，85，5： | 1 |
| 8 | Studying of weighted compact high-order nonlinear scheme WCNS-E-5 for complex flows显示文摘 | Liu X Deng X G Mac M L | 2004 | CFD Journal2004，13，2： | 1 |
| 9 | Comparative study of carbon dioxide reforming of methane to synthesis gas over Ni/La2O3 and conventional nickel-based catalysts 显示文摘 | Verykios X E Mac Donald S M | 1996 | J Phys Chem1996，100，： | 1 |
| 10 | Shark Depredation Rates in Pelagic Longline Fisheries:A Case Study from the Northwest Atlantic显示文摘 | Mac Neil M A Carlson J K Beerkircher L R | 2009 | ICES Journal of Marine Science2009，，4： | 1 |
| 11 | Consumption of pornographic materials among early adolescents in Hong Kong: Profiles and psychoso- cial correlates显示文摘 | SHEK D T L MAC M S | 2012 | Disab Hum Dev2012，，2： | 1 |
| 12 | refractory periodontitis associated with abnormal polymorphonuclear leukocyte显示文摘 | Herzberg M Wolff L Hardie N | 1992 | J periodontol1992，63，： | 1 |
| 13 | Graphical representation and stability conditions of predator- prey interactions显示文摘 | Rosenzweig M L Mac Arthur R | 1963 | Am Nat1963，97，： | 1 |
| 14 | In vitro cytotoxicity of a remineralizing resin-based calcium phosphate cement显示文摘 | BOLAND E J MAC DOUGALL M M CARNES D L | 2006 | Dent Mater2006，22，4： | 1 |
| 15 | Fiber inclination model of three-dimensional textile structural composites显示文摘 | YANG J M MAC L CHOU T W | 1986 | Journal of Composite Material1986，20，5： | 1 |
| 16 | Tribo-layer and its role in dry sliding wear of Ti-6A1-4V alloy显示文摘 | Mac Y S Wang L Chert K M et a/ | 2013 | Wear2013，297，： | 1 |
| 17 | Elevation of creatine in red blood cells in vegetarians and nonvegetarians after creatine supplementation显示文摘 | Mac Cormick V M Hill L M Mac Neil L | 2004 | Can J Appl Physiol Rev2004，29，6： | 1 |
| 18 | Purification and characterization of an alkaline protease from the marine yeast Aureobasidium pullulans for bioac- tive peptide production from different sources 显示文摘 | MAC L NI X M CHI Z M | 2007 | Mar Biotechno12007，9，： | 1 |
| 19 | Morphological, electrical, electromagnetic interferenc'e (EMI) shiel- ding, and tribologieal properties of functionalized multi-walled carbon nanotube/poly methyl methacrylate (PM MA) composites显示文摘 | HUANG Y L YUEN S M MAC C eta| | 2009 | Compos Sci Technol2009，69，： | 1 |
| 20 | Statistical methods for dissecting triploid endospermtraits using molecular markers: an autogamous model显示文摘 | WU R L MAC X MARIA G M | 2002 | Genetics2002，162，： | 1 |
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