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| 1 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 2 | 质子泵抑制剂增高伏立康唑血药浓度显示文摘伏立康唑治疗药物监测与侵袭性真菌病的疗效密切相关。在侵袭性曲霉病的治疗中临床上普遍接受的伏立康唑目标治疗浓度为谷浓度1~2 mg/L,谷浓度≤5.5 mg/L可预防不良反应发生。由于不同患者伏立康唑的生物利用度有较大差异,故目标血药浓度较难达到,尤其是谷浓度。
Boyd等报道1例额叶曲霉病患者联合应用质子泵抑制剂奥美拉唑,使伏立康唑达到目标治疗浓度。 | Boyd NK Zoellner CL Swancutt MA 吴真 徐晓刚 | 2015 | 中国感染与化疗杂志2015，15，1： | 2 |
| 3 | 弓形虫感染引起小胶质细胞与神经元的接触以及细胞体周边抑制性突触丧失显示文摘大脑内的感染和炎症会引起神经元连通性和功能的改变。细胞内的原生动物寄生虫,弓形虫,是一种感染脑部的病原体,可引起脑炎和癫痫发作。这种寄生虫的持续感染还与行为改变和发生精神疾病(包括精神分裂症)的风险增加有关。目前来自人类和小鼠模型的研究证据表明,癫痫发作和精神分裂症均由抑制性突触的丧失或功能障碍引起。与此相符,我们最近报道了持续性弓形虫感染改变谷氨酸脱羧酶67(GAD67)的分布,该酶在抑制性突触中催化GABA的合成。这些变化可能反映突触前装置在抑制性神经元中的重新分布或抑制性神经末梢的丧失。为了直接评估后者的可能性,我们采用序列块面扫描电子显微镜(SBFSEM)并量化寄生虫感染后新皮质和海马中的细胞体周边抑制性突触。持续感染不仅导致明显的细胞体周边突触丧失,而且还诱导髓样来源的细胞对神经元细胞体的包封。免疫组织化学、遗传和超微结构分析显示,这些髓样来源的细胞包括活化的小胶质细胞。最后,超微结构分析确定了包膜于细胞体周围神经末梢的髓样来源的细胞,提示它们可能会主动置换或吞噬突触元件。因此,这些结果表明,活化的小胶质细胞有助于寄生虫感染后细胞体周围抑制突触损失,并对于弓形虫的持续感染可能如何导致癫痫发作和精神疾病提供了一种新的机制。 | Carrillo GL Ballard VA Glausen T Boone Z Teamer J Hinkson CL Wohlfert EA Blader IJ Fox MA 杜一星(编译) | 2020 | 神经损伤与功能重建2020，15，3： | 2 |
| 4 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 5 | Is fusion necessary for surgical-ly treated burst factures of the thoraco lumber and lumbar spine?Aprospective randomized study显示文摘 | WANG ST MA HL LIU CL | 2006 | Spine2006，31，23： | 1 |
| 6 | Total parenteral nutrition显示文摘 | Peden VH Witzleben CL Skelton MA | 1971 | J Pediatr1971，78，1： | 1 |
| 7 | Effect of allopurinol on the survival of experimental pig flaps 显示文摘 | Louis AP Andrew MA Kerrigan CL | 1992 | Plast Reconstr Surg1992，89，6： | 1 |
| 8 | Calcified atherosclerosis in different vascular beds and the risk of mortality显示文摘 | Allison MA Hsi S Wassel CL | | 0，，01： | 1 |
| 9 | Efficacy and safe- ty of deep brain stimulation in patients with medication-in- duced tardive dyskinesia and/or dystonia:a systematic review 显示文摘 | Mentzel CL Tenback DE Tijssen MA | 2012 | J Clin Psychiatry2012，73，11： | 1 |
| 10 | Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients显示文摘 | Jamerson K Weber MA Bakris CL | 2008 | N Engl J Med2008，359，23： | 1 |
| 11 | Changes in procoagulant and fibrinolytic gene expression during blemycininduced lung injury in the mouse显示文摘 | Olman MA Iackman N Gladson CL | 1995 | J Clin Invest1995，96，3： | 1 |
| 12 | ImmunoCyt and cytokeratin,20 immunocytochemistry as adjunct markers for urine cytologic detection of bladder cancer:a prospective study显示文摘 | Li HX Li M Li CL Ma JH Wang MR Rao J | | 0，，： | 1 |
| 13 | Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-over- expressing metastatic breast cancer 显示文摘 | Vogel CL Cobleigh MA Tripathy D | 2002 | J Clin Oncol2002，20，3： | 1 |
| 14 | DEVELOPMENT OF Sr0.69La0.31F2.31+SrSSOLID ELECTROLYTE SENSOR AND ITS APPLICATION显示文摘DEVELOPMENTOFSr0.69La0.31F2.31+SrSSOLIDELECTROLYTESENSORANDITSAPPLICATIONZhai;YuchunMa;PingTian;YanwenXiao;FeiJi;Chun?.. | ZHAI, YC MA, P TIAN, YW XIAO, F JI, CL | 1995 | 中国有色金属学会会刊:英文版1995，5，1： | 1 |
| 15 | Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease显示文摘 | Cobleigh MA Vogel CL Tripathy D | 1999 | JClin Oncol1999，17，9： | 1 |
| 16 | The JT interval as a depolarization independent measurement of repolarization:Lessons from catheter ablation of the Wolff-Parkinson-White syndrome显示文摘 | Case CL Gillette PC | 1995 | PACE1995，18，12： | 1 |
| 17 | Predicting registered nurse job satisfaction and intent to leave显示文摘 | Larrabee JH Janney MA Ostrow CL | 2003 | Journal of Nursing Administration2003，33，5： | 1 |
| 18 | Is fusion necessary for surgically treated burst fractures of the thoracolnmbar and lumbar spine?A prospective, randomized study显示文摘 | Wang ST Ma HL Lu CL | 2006 | Spine2006，31，： | 1 |
| 19 | Development of microsatellite markers from an ectomycorrhizal fungus, Laccaria amethystina, by a dual-suppression-PCR technique显示文摘 | Wadud MA Lian CL Nara K | 2006 | Molecular Ecology Notes2006，6，1： | 1 |
| 20 | Relationships of protective factors to stress and symptoms of illness 显示文摘 | DOLBIER CL SMITH SE STEINHARDT MA | 2007 | American Journal of Health Behavior2007，，31： | 1 |
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