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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。 | 刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR | 2016 | 中华高血压杂志2016，24，8： | 4 |
| 3 | Evaluation of landfarm remediation of hydrocarbon-contaminated soil at the inveresk railyard,Launceston,Australia显示文摘 | Line MA Garlandh CD and Crowley M | 1996 | Waste Management1996，16，7： | 1 |
| 4 | Complement-induced endothelial dysfunction in rabbits: mechanism, recovery, and gender differences显示文摘 | Lennon PF Collard CD Morrissey MA | 1996 | Am J Physiol1996，270，62： | 1 |
| 5 | Increased urinary albu- min excretion,endothelial dysfunction, and chronic low-grade in- flammation in type 2 diabetes: progressive, interrelated, and inde- pendently associated with risk of death显示文摘 | Stehouwer CD Gall MA Twisk JW | 2002 | Diabetes2002，51，4： | 1 |
| 6 | Prognostic value of bronchiectasis in patients with moderate - to - se- vere chronic obstructive pulmonary disease显示文摘 | Martinez - Garcia MA de la Rosa CD Soler - Cataluna JJ | 2013 | Am J Respir Crit Care Med2013，187，8： | 1 |
| 7 | Increased urinary albumin excretion,endothelial dysfunction,and chronic low-grade inflammation in type 2 diabetes:progressive,interrelated,and independently associated with risk of death显示文摘 | Stehouwer CD Gall MA Twisk JW | 2002 | Diabetes2002，51，4： | 1 |
| 8 | The effect of total knee arthroplasty design on extensor mechanism function显示文摘 | Mahoney OM McClung CD dela Rosa MA | 2002 | J Arthroplasty2002，17，： | 1 |
| 9 | MRI shows increased sciatic nerve cross sectional area in inherited and inflammatory neuropathies显示文摘 | Sinclair CD Miranda MA Cowley P | 2011 | J Nenrol Nenrosurg Psychiatry2011，82，11： | 1 |
| 10 | Allergy practice word-wide: a report by the world allergy organization specialty andtraining council 显示文摘 | WamerJO Kaliner MA Crisci CD | 2006 | Int Arch Allergy Immunol2006，139，2： | 1 |
| 11 | Increased urinary albumin excretion,endothelial dvsfunction and chronic low-grade inflammation in type-2 diabetes:progressive,interre-lated,and independently associated with risk of death显示文摘 | Stehouwer CD Gall MA Twisk JW | 2002 | Diabetes2002，51，4： | 1 |
| 12 | Loss of promyelocytic leuke- mia protein in human gastric cancers显示文摘 | Lee HE Jee CD Kim MA | 2007 | Cancer Lett2007，247，1： | 1 |
| 13 | Microbial contamination in two antimicrobial and four control brands of alginate impression material显示文摘 | Rise CD Dykstra MA Feil PH | 1992 | J Prosthet Dent1992，67，： | 1 |
| 14 | Diagnosis and management of acute myeloid leukemia in adults:recommendations from an international expert panel,on behalf of the European LeukemiaNet显示文摘 | Dhner H Estey EH Amadori S Appelbaum FR Büchner T Burnett AK Dombret H Fenaux P Grimwade D Larson RA Lo-Coco F Naoe T Niederwieser D Ossenkoppele GJ Sanz MA Sierra J Tallman MS Lwenberg B Bloomfield CD | 2010 | {H}Blood2010，，03： | 1 |
| 15 | The effect of total knee arthroplasty design on extensor mechanism function 显示文摘 | Mahoney OM McClung CD dela Rosa MA | 2002 | J Arthroplasty2002，17，4： | 1 |
| 16 | Apple pomance: a versatile substrate for biotechnology applications显示文摘 | Francielo V Patrcia MA Femanda S et cd | 2008 | Critical Reviews in Biotechnology2008，28，1： | 1 |
| 17 | Allergy practice worldwide:a report by the World Allergy Organization Specialtyand Training Council显示文摘 | Warner JO Kaliner MA Crisci CD | | 0，，： | 1 |
| 18 | Silencing of the maternally imprinted tumor suppressor ARHI contributes to follicular thyroid carcinogenesis显示文摘 | Weber F Aldred MA Morrison CD | 2005 | J Clin Endocrinol Metabolism2005，90，2： | 1 |
| 19 | Prospective, pilot, open-label, short-term study of conversion to leflunomide reverses chronic renal allograft dysfunetion显示文摘 | Hardinger KL Wang CD Schnitzler MA | 2002 | Am J Transplant2002，2，9： | 1 |
| 20 | Molecular and clinical advances in core binding factor primary acute myeloid leukemia: a paradigm for translational research in malignant hematology显示文摘 | Marcucci G Caligiuri MA Bloomfield CD | 2000 | Cancer Invest2000，18，8： | 1 |
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