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| 1 | Resting heart rate control and prognosis in coronary artery disease patients with hypertension previously treated with bisoprolol:a subgroup analysis of the BISO-CAD study显示文摘Background:Resting heart rate(RHR)is considered as a strong predictor of total mortality and hospitalization due to heart failure in hypertension patients.Bisoprolol fumarate,a second-generation beta-adrenoreceptor blockers(β-blocker)is commonly prescribed drug to manage hypertension.The present study was to retrospectively evaluate changes in the average RHR and its association with cardiovascular outcomes in bisoprolol-treated coronary artery disease(CAD)patients from the CAD treated with bisoprolol(BISO-CAD)study who had comorbid hypertension.Methods::We performed ad-hoc analysis for hypertension sub-group of the BISO-CAD study(n=866),which was a phase IV,multination,multi-center,single-arm,observational study carried out from October 2011 to July 2015 across China,South Korea,and Vietnam.Multivariate regression analysis was used to identify factors associated with incidence of composite cardiac clinical outcome(CCCO),the results were presented as adjusted odds ratio(OR)along with 95%confidence interval(CI)and adjusted P value.Results::A total of 681 patients(mean age:64.77±10.33 years)with hypertension from BISO-CAD study were included in the analysis.Bisoprolol improved CCCOs in CAD patients with comorbid hypertension,with RHR<65 and<70 beats/min compared with RHR≥65 and≥75 beats/min,respectively,in the efficacy analysis(EA)set.In addition,it lowered RHR in both intent-to-treat(ITT)and EA groups after 6,12,and 18 months of treatment.Further,RHR 70 to 74 beats/min resulted in significantly higher risk of CCCOs EA set of patients(adjusted OR:4.34;95%CI:1.19-15.89;P=0.03).Also,events of hospitalization due to acute coronary syndrome were higher when RHR 69 to 74 beats/min compared to RHR<69 beats/min in ITT patients.Conclusion::Bisoprolol can effectively reduce RHR in Asian CAD patients with comorbid hypertension and hence,improve CCCO without affecting their blood pressure. | Yun-Dai Chen Xin-Chun Yang Vinh Nguyen Pham Shi-An Huang Guo-Sheng Fu Xiao-Ping Chen Binh Quang Truong Yu Yang Shao-Wen Liu Tian-Rong Ma Dong-Soo Kim Tae-hoon Kim | 2020 | Chinese Medical Journal2020，，10： | 10 |
| 2 | A novel role of hematopoietic CCL5 in promoting triple-negative mammary tumor progression by regulating generation of myeloid-derived suppressor cells显示文摘CCL5 是响应压力信号在有免疫力、非有免疫力的房间的一个宽数组表示的 CC chemokine 家庭的一个成员。有先进人的乳癌的 CCL5 表示相互关联。然而,它行动的功能的意义和模式没被建立。这里,我们证明 CCL5 缺乏的老鼠对高度好攻击的、三元组否定的乳房的肿瘤生长抵抗。造血的 CCL5 在这显型是主导的。造血的 CCL5 的缺席由积累 Ly6C +/Gr-1+, 的异常产生导出 myeloid 的 suppressor 房间(MDSC )> 嗨有损害能力到的 和 Ly6G + MDSC 压制 CD8 + T 房间的 cytotoxicity。CCL5 的这些性质在 orthotopic 和自发的乳房的肿瘤被观察。CCL5 的调停抗体的全身的封锁禁止肿瘤前进并且对非产生免疫性的肿瘤提高治疗学的种痘的功效。CCL5 也帮助维持人的 MDSC 的抑制免疫力的能力。我们的学习揭开经由与导出肿瘤的刺激殖民地的因素在合作在骨头髓产生 MDSC 支持乳房的肿瘤前进的造血地导出的 CCL5 的一项新奇、 chemokine 独立的活动。学习在在造血的分隔空间和肿瘤壁龛之间的相互影响上打开可观的灯。因为在正常生理学的这个分子的明显的非必需的性质, CCL5 可以象有 MDSC 渗入的重要数量的大量稳固的肿瘤一样为乳癌在免疫疗法代表一个优秀治疗学的目标。 | Yan Zhang Dandan Lv Ha-Jeong Kim Robert A Kurt Wen Bu Yi Li Xiaojing Ma | 2013 | Cell Research2013，23，3： | 9 |
| 3 | Regulation of cytokine production during phagocytosis of apoptotic cells显示文摘自我忍耐的损失和汽车反应的淋巴细胞的扩大是汽车免疫的基础。当保证的协调过程与非病理学的结果调整了细胞质和压力反应, Apoptosis 和由吞噬细胞的 apoptotic 房间的快速的清理通常发生。在 apoptotic 房间的清理的缺点将贡献自我反应的淋巴细胞的产生,它驾驶象风湿性关节炎(RA ) 和全身的豺狼座 erythematosus (SLE ) 那样的自体免疫的混乱。cytokines (IL-12, IL-23,和 IL-27 ) 和 IL-10 的 IL-12 家庭被吞噬细胞的巨噬细胞生产并且在对病原体的有免疫力的回答期间在介绍抗原的房间(APC ) 和受动器淋巴细胞的规定起关键作用。这些 cytokines 和他们的 dysregulated 活动的不恰当的表示强烈在几自体免疫的疾病的致病被含有。由吞噬细胞的 APC 的支持 inflammatory 和反煽动性的 cytokines 的生产精巧地作为内在的机制的部分在 apoptotic 房间的摄取期间被调整阻止煽动性的自体免疫的反应。怎么导出房间的信号调整的 apoptotic cytokine 生产糟糕被理解。由我们的组的最近的研究证明由激活的巨噬细胞的 apoptotic 房间的那个吞噬作用由激活一个新奇抄写抑压者导致 IL-12 p35 基因表示的强壮的抑制,我们把它称为 GC 有约束力的蛋白质(GC-BP ) ,通过酷氨酸 dephosphorylation。我们开始也正在理解位于 apoptotic 下面的分子的机制由吞噬细胞的 IL-10 的被触发房间的生产。阐明的这些研究愿望帮助一些新奇有免疫力的规章的机制并且与潜力探索对汽车抗原的有免疫力的回答的规定为自体免疫的混乱的处理发现新治疗学的目标。 | Elaine Y Chung Sun Jung Kim Xiao Jing Ma | 2006 | Cell Research2006，16，2： | 9 |
| 4 | :CL5 as a potential immunotherapeutic target in triple-negative breast cancer显示文摘乳癌(BC ) 是在在世界上的女人之中的死亡的一个领先的原因。迄今为止,很多个分子作为疾病地位指示物和治疗学的目标被建立了。在他们之中知道的最好是雌激素 receptor-α(ER-α) ,孕酮受体(PR ) 和 HER-2/neu。大约 15 % -20%BC 病人不对指向支持肿瘤的因素的这些班的治疗有效地作出回应。因此,另外的目标强烈并且着急地被寻求在以后在为为否定的人的英国计算机学会的治疗嗯, PR 和 HER-2,所谓的三元组否定的 BC (TNBC ) 。最近的临床的工作揭示了那 CC chemokine ligand (CCL5 ) 5 强烈与 BC 的前进被联系,特别地 TNBC。CCL5 怎么贡献 TNBC 的发展,很好没被理解。试验性的动物研究开始处理了机械学的问题。在这篇文章,我们将考察临床并且在导致了我们在 TNBC 的那指向的 CCL5 将有的自己的假设的这个区域的实验室工作有一般生理学上的最小的不利影响的有利治疗学的结果。 | Dandan Lv Yan Zhang Ha-Jeong Kim Lixing Zhang Xiaojing Ma | 2013 | Cellular & Molecular Immunology2013，10，4： | 7 |
| 5 | Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation显示文摘Mitochondrial 反应的氧种类(mROS ) 被认为有害到房间。然而,他们的生理的角色一直不作为表明调停人是彻底地探索了。这里,我们调查了 mROS 是否从 mitochondrial 电子运输链(mETC ) 产生了复杂我刺激了肌肉区别。我们的结果证明 mROS 的数量被增加并且锰 superoxide dismutase (MnSOD ) 在肌肉区别期间经由 NF-B 激活被导致。指向线粒体的抗氧化剂(MitoQ 和 MitoTEMPOL ) 和指向线粒体的过氧化氢酶减少了没有影响 ATP 的数量的 mROS 数量和压制的肌肉区别。Mitochondrial 改变包括在线粒体的数字和尺寸的 mitochondrial 抄写因素 A 和增加的正式就职,并且功能的激活在肌肉区别期间被观察。特别地,增加了 mETC 建筑群的表示层次我子单元和建筑群的一项更高的活动我比另外的建筑群被观察。毒鱼藤素, mETC 建筑群的一个禁止者我,减少 mitochondrial NADH/NAD+ 比率和 mROS 层次在肌肉区别期间。mROS 铺平的我用小介入 RNA 和毒鱼藤素减少了的建筑群的抑制,压制的肌肉区别,和有伴随物的弄空的 ATP 层次在 glycolysis 增加。从这些结果,我们结束那复杂我导出 | Seonmin Lee Eunyoung Tak Jisun Lee MA Rashid Michael P Murphy Joohun Ha Sung Soo Kim | 2011 | Cell Research2011，21，5： | 4 |
| 6 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 7 | High-performance flexible BiCMOS electronics based on single-crystal Si nanomembrane显示文摘In this work,we have demonstrated for the first time integrated flexible bipolar-complementary metal-oxide-semiconductor(BiCMOS)thin-film transistors(TFTs)based on a transferable single crystalline Si nanomembrane(Si NM)on a single piece of bendable plastic substrate.The n-channel,p-channel metal-oxide semiconductor field-effect transistors(N-MOSFETs&P-MOSFETs),and NPN bipolar junction transistors(BJTs)were realized together on a 340-nm thick Si NM layer with minimized processing complexity at low cost for advanced flexible electronic applications.The fabrication process was simplified by thoughtfully arranging the sequence of necessary ion implantation steps with carefully selected energies,doses and anneal conditions,and by wisely combining some costly processing steps that are otherwise separately needed for all three types of transistors.All types of TFTs demonstrated excellent DC and radio-frequency(RF)characteristics and exhibited stable transconductance and current gain under bending conditions.Overall,Si NM-based flexible BiCMOS TFTs offer great promises for high-performance and multifunctional future flexible electronics applications and is expected to provide a much larger and more versatile platform to address a broader range of applications.Moreover,the flexible BiCMOS process proposed and demonstrated here is compatible with commercial microfabrication technology,making its adaptation to future commercial use straightforward. | Jung-Hun Seo Kan Zhang Munho Kim Weidong Zhou Zhenqiang Ma | 2017 | npj Flexible Electronics2017，1，1： | 3 |
| 8 | Risk factors of electrocoagulation syndrome after esophageal endoscopic submucosal dissection显示文摘AIM To investigate post endoscopic submucosal dissection electrocoagulation syndrome(PEECS) of the esophagus.METHODS We analyzed 55 consecutive cases with esophageal endoscopic submucosal dissection for superficial esophageal squamous neoplasms at a tertiary referral hospital in South Korea. Esophageal PEECS was defined as 'mild' meeting one of the following criteria without any obvious perforation: fever(≥ 37.8 ℃), leukocytosis(> 10800 cells/μl), or regional chest pain more than 5/10 points as rated on a numeric pain intensity scale. The grade of PEECS was determined as 'severe' when meet two or more of above criteria.RESULTS We included 51 cases without obvious complications in the analysis. The incidence of mild and severe esophageal PEECS was 47.1% and 17.6%, respectively. Risk factor analysis revealed that resected area, procedure time, and muscle layer exposure were significantly associated with PEECS. In multivariate analysis, a resected area larger than 6.0 cm^2(OR = 4.995, 95%CI: 1.110-22.489, P = 0.036) and muscle layer exposure(OR = 5.661, 95%CI: 1.422-22.534, P = 0.014) were independent predictors of esophageal PEECS. All patients with PEECS had favorable outcomes with conservative management approaches, such as intravenous hydration or antibiotics.CONCLUSION Clinicians should consider the possibility of esophageal PEECS when the resected area exceeds 6.0 cm^2 or when the muscle layer exposure is noted. | Dae Won Ma Young Hoon Youn Da Hyun Jung Jae Jun Park Jie-Hyun Kim Hyojin Park | 2018 | World Journal of Gastroenterology2018，24，10： | 3 |
| 9 | Angiogenic peptide hydrogels for treatment of traumatic brain injury显示文摘Traumatic brain injury(TBI)impacts over 3.17 million Americans.Management of hemorrhage and coagulation caused by vascular disruption after TBI is critical for the recovery of patients.Cerebrovascular pathologies play an important role in the underlying mechanisms of TBI.The objective of this study is to evaluate a novel regenerative medicine for the injured tissue after brain injury.We utilized a recently described synthetic growth factor with angiogenic potential to facilitate vascular growth in situ at the injury site.Previous work has shown how this injectable self-assembling peptide-based hydrogel(SAPH)creates a regenerative microenvironment for neovascularization at the injury site.Supramolecular assembly allows for thixotropy;the injectable drug delivery system provides sustained in vivo efficacy.In this study,a moderate blunt injury model was used to cause physical vascular damage and hemorrhage.The angiogenic SAPH was then applied directly on the injured rat brain.At day 7 post-TBI,significantly more blood vessels were observed than the sham and injury control group,as well as activation of VEGF-receptor 2,demonstrating the robust angiogenic response elicited by the angiogenic SAPH.Vascular markers von-Willebrand factor(vWF)andα-smooth muscle actin(α-SMA)showed a concomitant increase with blood vessel density in response to the angiogenic SAPH.Moreover,blood brain barrier integrity and blood coagulation were also examined as the parameters to indicate wound recovery post TBI.Neuronal rescue examination by NeuN and myelin basic protein staining showed that the angiogenic SAPH may provide and neuroprotective benefit in the long-term recovery. | Xiaotang Ma Agnieszka Agas Zain Siddiqui KaKyung Kim Patricia Iglesias-Montoro Jagathi Kalluru Vivek Kumar James Haorah | 2020 | Bioactive Materials2020，5，1： | 3 |
| 10 | Whole Exome Sequencing to Identify a Novel Gene (Caveolin-1) Associated With Human Pulmonary Arterial Hypertension显示文摘 | Eric D. Austin Lijiang Ma Charles LeDuc Erika Berman Rosenzweig Alain Borczuk John A. Phillips Teresa Palomero Pavel Sumazin Hyunjae R. Kim Megha H. Talati James West James E. Loyd Wendy K. Chung | 2012 | Circulation: Cardiovascular Genetics2012，，3： | 2 |
| 11 | Understanding of the capacity Contribution of carbon in phosphorus-carbon composites for high-performance anodes in lithium ion batteries显示文摘Phosphorus has recently received extensive attention as a promising anode for lithium ion batteries (LIB ) due to its high theoretical capacity of 2,596 | Jiantie Xu In-Yup Jeon Jianmin Ma Yuhai Dou Seok-Jin Kim Jeong-Min Seo Huakun Liu Shixue Dou Jong-Beom Baek Liming Dai | 2017 | Nano Research2017，10，4： | 2 |
| 12 | Rational Design and Application of an Indolium-Derived Heptamethine Cyanine with Record-Long Second Near-Infrared Emission显示文摘Heptamethine cyanine dyes,typified by indocyanine green,have been extensively employed as bioimaging indicators and theranostic agents.Significant efforts have been made to develop functional heptamethine cyanine dyes with outstanding bioimaging and theranostic utilities.In this work,we rationally designed and successfully developed a novel indolium-like heptamethine cyanine dye by installing indolium-derived polycyclic aromatic hydrocarbons on the terminal ends of a conjugated polyene backbone.This dye showed excellent photostability and showed bright fluorescent emission in the second near-infrared(NIR-Ⅱ)window with a peak at approximately 1120 nm.Such long wavelength emission prompted a superior bioimaging resolution in vivo.In particular,this NIR-Ⅱ dye had the remarkable capability of marking the blood vessels of the hindlimbs,abdomens,and brains of mice.More significantly,this dye involved a typical indolium-like heptamethine skeleton and exhibited two strong absorption bands in the 700–1300 nm NIR range,which endowed it with an intrinsic tumor-targeting capability and a high photothermal conversion efficiency(up to 68.2%),serving for the photothermal therapy of tumors under the guidance of NIR-Ⅱ fluorescence imaging.This work provides an efficient design strategy for achieving indolium-like heptamethine cyanine dyes with further NIR-Ⅱ emission. | Xiaoxie Ma Yurou Huang Syed Ali Abbas Abedi Heejeong Kim Tan Teck Boon Davin Xiaogang Liu Wen-Chao Yang Yao Sun Sheng Hua Liu Jun Yin Juyoung Yoon Guang-Fu Yang | 2022 | CCS Chemistry2022，4，6： | 2 |
| 13 | Type I interferon: the mediator of bacterial infection-induced necroptosis显示文摘 | Qinglin Du Jianping Xie Ha-Jeong Kim Xiaojing Ma | 2013 | Cellular & Molecular Immunology2013，10，1： | 2 |
| 14 | Alterations of Gefitinib Pharmacokinetics by Co-administration of Herbal Medications in Rats显示文摘Objective: To evaluate the potential pharmacokinetic interactions of the anticancer agent gefitinib(Iressa?) and the oriental medications Guipi Decoction(归脾汤, GPD, Guibi-tang in Korean) and Bawu Decoction(八物汤, BWD, Palmul-tang in Korean). Methods: Methylcellulose(MC, control), GPD(1,200 mg/kg), or BWD(6,000 mg/kg) was orally administered to rats either as a single dose or multiple doses prior to gefitinib administration. To examine the effects of a single dose of the herbal medicines, gefitinib(10 mg/kg) was orally administered after 5 min or 1 h of MC or the herbal medicine pretreatments. To examine the effects of the multiple doses of the herbal medicines, gefitinib(10 mg/kg) was orally administered following 7 consecutive days of the administration of MC or each herbal medicine. The plasma concentrations of gefitinib were determined with liquid chromatography-tandem mass spectrometry assay. The plasma concentration-time profiles of gefitinib were analyzed with a noncompartmental analysis. Results: Gefitinib was rapidly absorbed and showed a monoexponential decline with an elimination half-life of 3.7–4.1 h. The pharmacokinetics of gefitinib was not affected by GPD pretreatment. However, a significantly lower maximum plasma concentration(Cmax, P<0.05) and area under the curve(P<0.05), and a delayed time to reach Cmax(Tmax, P<0.01) were observed in both single-and multipledose BWD-pretreated rats compared with the control rats. Conclusions: BWD and not GPD might delay and interfere with gefitinib absorption. Further evaluations of the clinical significance of these findings are needed. | Kwon-Yeon Weon Min Gi Kim Soyoung Shin Tae Hwan Kim Sang Hoon Joo Eunsook Ma Seok Won Jeong Sun Dong Yoo Yu Seok Youn Beom Soo Shin | 2018 | Chinese Journal of Integrative Medicine2018，24，6： | 2 |
| 15 | Effects of Trichoderma harzianum YC_(459) and soil types on seed germination and seedling growth in rock slope restoration显示文摘We carried out experiments with various concentrations of Trichoderma harzianum YC459 in different soil types(forest soil, mixed soil,merchantable soil, and leaf mold soil) to evaluate its effect on seed germination and seedling establishment of four species(Festuca arundinacea Schreb., Dianthus barbatus var. asiaticus Nakai,Lespedeza cyrtobotrya Miq., and Parthenocissus tricuspidata Planch) for rock slope restoration. We also investigated the use of drilled slanted holes on the rock slopes for seedling establishment. The results showed that T. harzianum concentration had significant effects on seed germination, seedling growth, and seedling survival for all the species with different soil types. Seed germination and survival rates peaked at 5% T. harzianum concentration with leaf mold soil and decreased as T. harzianum concentration increased from 5% to 10%. Seedling survival rates of all four species were generally lowest at 0% T. harzianum concentration in all soil types.The height of F. arundinacea and L. cyrtobotrya peaked at 5% T. harzianum concentration whereas that of D. barbatus and P. tricuspidata peaked at 10%T. harzianum concentration. We concluded that 5% T. harzianum concentration with leaf mold soil is appropriate for seed germination and seedling survival rates of most species, thus enhancing seedling establishment. Practical application of the findings of this study will contribute in the vegetation restoration of steep rocks in mountain environments. | MA Hoseop ETTAGBOR Hans Enukwa KIM Choonsig | 2018 | Journal of Mountain Science2018，15，4： | 2 |
| 16 | Newπ-conjugated cyanostilbene derivatives:Synthesis,characterization and aggregation-induced emission显示文摘Two novel π-conjugated cyanostilbene derivatives,FLU-CNPH and TPE-CNPH,were designed and synthesized by introducing the strong electron donor 1,4-dihydropyrro[3,2-b]indole and AIE electron donor tetraphenylethylene(TPE)to the(3',5'-bis(trifluoromethyl)-biphenyl-4-yl)-acetonitrile,respectively.Both of them were fully characterized and their AIE behaviors were investigated using fluorescence spectroscopy and FE-SEM images.Their optimized structures and frontier molecular orbitals were calculated with the DFT by using Materials Studio 7.0 software to study the relationship between the structure and properties. | Fang Wang Xue Li Sheng Wang Cheng-Peng Li Huan Dong Xiang Ma Sung-Hoon Kim De-Rong Cao | 2016 | Chinese Chemical Letters2016，27，10： | 2 |
| 17 | 18 F-fluorodeoxyglucose positron emission tomography–computed tomography for the evaluation of bone metastasis in patients with gastric cancer显示文摘 | Dae Won Ma Jie-Hyun Kim Tae Joo Jeon Yong Chan Lee Mijin Yun Young Hoon Youn Hyojin Park Sang In Lee | 2013 | Digestive and Liver Disease2013，，： | 2 |
| 18 | Aberrant unclear factor-K appaB/Rel expression and the pathogenesis of breast cancer 显示文摘 | Sovak MA Bellas RE Kim DW | 1997 | Clin Invest1997，100，12： | 1 |
| 19 | Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design,synthesis,and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity显示文摘 | Lew W Williams MA | 1997 | J Am Chem Soc1997，119，： | 1 |
| 20 | Hyaluronan facilitates invasion of colon carcinoma cells in vitro via interaction with CD44显示文摘 | WHEELER MA WILSON CM | 2004 | Cancer Res2004，64，13： | 1 |
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