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| 1 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 2 | Protective effect of carnosol on CC14-induced acute liver damage in rats 显示文摘 | Sotelo-Felix J I Martinez-Fong D Muriel De la Torre P | 2002 | Eur J Gastroenterol Hepatol2002，14，9： | 1 |
| 3 | Dopamine depletion impairs precursor cell prolifer-ation in Parkinson disease显示文摘 | Hoglinger GU Rizk P Muriel MP Duyckaerts C Oertel WH Caille I Hirsch EC | | 0，，： | 1 |
| 4 | Effects of silyrnarin and vitamins E and C on liver damage induced by prolonged biliary obstruction in the rat 显示文摘 | Muriel P MorenoMG | 2004 | Pharmacol and Toxicol2004，94，2： | 1 |
| 5 | Role of free radicals in liver diseases显示文摘 | Muriel P | 2009 | Hepatology2009，3，4： | 1 |
| 6 | Thalidomide ameliorates carbon tetrachlofide induced cirrhosis in the rat 显示文摘 | Muriel P Femgmdez Martinez E Alvarez V | 2003 | Eur J Gastroenteml Hepatol2003，15，9： | 1 |
| 7 | Protective effect of s2adenosyl212methio2nine on liver damage induced by biliaryob-struction in rats :a histological , ultra2tructural and biochemical approach显示文摘 | Muriel P Suarez OR Gonzalez P | 1994 | J Hepatol1994，21，1： | 1 |
| 8 | Multi-technique Monitoring of Ocean Tide Loading in Northern France显示文摘 | Muriel L Florseh N Boy J P | 2008 | C R Geoscience2008，340，6： | 1 |
| 9 | Effects of s2adeno2syl212methionine and interfer on 2alpha2bon liver damage induced by bile ductligation in rats 显示文摘 | Muriel P Gastro V | 1998 | J Appl Toxicol1998，18，2： | 1 |
| 10 | Effects of silymarin and vitamins E and C on liver damage induced by prolonged biliary obstruction in the rat显示文摘 | MURIEL P MORENO MG | 2004 | Pharmacol Toxicol2004，94，2： | 1 |
| 11 | Phosphoinositide 3 - Kinase signaling - which way to target? 显示文摘 | MATTHIAS P W MARKETA Z MURIEL L | 2003 | Trends Pharmacol Sci2003，24，7： | 1 |
| 12 | Inhibition of mitochondrial respiration by nitric oxide is independent of membrane fluidity modulation or oxidation of sulfhydryl groups 显示文摘 | PEREZ-ROJAS J M MURIEL P | 2005 | J Appl Toxicol2005，25，6： | 1 |
| 13 | Protective effect of s-adenosyl-l-methionine on liver damage induced by biliary obstruction in rats: a histological,ultratructural and biochemical approach显示文摘 | Muriel P Suarez OR Gonzalez P | 1994 | J Hepatol1994，21，1： | 1 |
| 14 | Dopamine depletion impairs precursor cell proliferation in parkinson disease 显示文摘 | Hoglinger GU Rizk P Muriel MP | 2004 | Nat Neurosei2004，7，7： | 1 |
| 15 | Effects of s-adenosyl-l-methionine and interfer on-alpha2b on liver damage induced by bile duct ligation in rats显示文摘 | Muriel P Gastro V | 1998 | J Appl Toxicol1998，18，2： | 1 |
| 16 | Prevention by silymarin of membrane alterations in acute CC14 liver damage 显示文摘 | Muriel P Mourelle M | 1990 | Journal of Applied Toxicology1990，10，4： | 1 |
| 17 | Prevention by silymarin of membrane alterations in acute CC14 liver damage 显示文摘 | Muriel P Mourelle M | 1990 | J Appl Toxicol1990，10，4： | 1 |
| 18 | Role of free radicals in liver diseases 显示文摘 | Muriel P | 2009 | Hepa-tology2009，3，： | 1 |
| 19 | Dose - respoes studies of interferon - alpha 2b on livertlbrosis and cholestasis induced by biliary obstruction in rats 显示文摘 | Muriel P Castro V | 1997 | Pharmacology1997，54，4： | 1 |
| 20 | Nitric oxide inhibits mitochondrial monoamine oxidase activitv and decreases outer mitochondrial membrane fluidity显示文摘 | Muriel P Perez-Rojas JM | 2003 | Comp Biochem Physiol C Toxicol Pharmacol2003，136，3： | 1 |
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