|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Removal of PCBs from wastewater using fly ash显示文摘 | HENDRIK N MURIELLE R PIERRE L | 2003 | Chemosphere2003，53，6： | 1 |
| 3 | Multi-technique Monitoring of Ocean Tide Loading in Northern France显示文摘 | Muriel L Florseh N Boy J P | 2008 | C R Geoscience2008，340，6： | 1 |
| 4 | Fatty acids and triacylglycerols profiles from different types of Iberian dry-cured hams 显示文摘 | PETRON M J MURIEL E TIMON M L | 2004 | Meat Science2004，68，： | 1 |
| 5 | Phosphoinositide 3 - Kinase signaling - which way to target? 显示文摘 | MATTHIAS P W MARKETA Z MURIEL L | 2003 | Trends Pharmacol Sci2003，24，7： | 1 |
| 6 | Demonstrating the Burden of Hypoglycemia on Patients’ Quality of Life in Diabetes Clinical Trials: Measurement Considerations for Hypoglycemia显示文摘 | Hélène Gilet Jean-Bernard Gruenberger Giovanni Bader Muriel Viala-Danten | 2012 | Value in Health2012，，8： | 1 |
| 7 | Haemophilus parasuis-novel proteins-hopes for vaccine显示文摘 | Mcvicker J Tabatabai L Muriel V S | 2005 | Respiratory Diseases of Livestock2005，10，： | 1 |
| 8 | Methodology of analysis of a spiral-wound module Application to PES membrane for ultrafiltration of skimmed milk显示文摘 | Bégoina L Murielle R B Chaufera B | 2006 | Desalination2006，192，： | 1 |
| 9 | Hatmophilus parasuis-novel proteins-hopes for vaccine显示文摘 | Mcvicker J Tabatabal L Muriel V S | 2005 | Respiratory diseases of livestock2005，10，： | 1 |
| 10 | Removal of PCBs from wastewater using fly ash显示文摘 | Hendrik N Murielle R Pierre L | | 0，，06： | 1 |
| 11 | Alkaline cleaning of PES membranes used in skimmed milk ultrafiltration:from reactor to spiral-wound module via a plate-and-frame module显示文摘 | Murielle R B Paugam L Bégoin L | 2006 | Desalination2006，191，： | 1 |
| 12 | Simple detem inaion of human sperm DNA fragmentation with an inproved sperm chromation dispersion test显示文摘 | FEMANGEZ JL MURIEL L GOVANES V | 2005 | Fertil Steril2005，84，1： | 1 |
| 13 | Removal of PCBs from wastewater using fly ash显示文摘 | HENDRIK N MURIELLE R PIERRE L | 2003 | Chemosphere2003，53，6： | 1 |
| 14 | Ketopantoate reductase activity is only encoded by ilvC in Corynebacterium gtutamicum 显示文摘 | Muriel M Christophe C Nic D L | 2003 | Journal of Biotechnology2003，104，： | 1 |
| 15 | Prevention of CCl4 induced liver cirrhosis by silymarin显示文摘 | Mourelle M Muriel P Favari L | 1989 | Fundam Clin Pharmacol1989，3，： | 1 |
| 16 | The sperm chromatin dis- persion test: a simple method for the determination of sperm DNA Fragmentation 显示文摘 | Femt:ndez JL Muriel L Rivero MT | 2003 | J Androl2003，24，1： | 1 |
| 17 | Y chromosome microdeletions, sperm DNA fragmentation and sperm oxidative stress as causes of recurrent spontaneous abortion of unknown etiology 显示文摘 | Bellver J Meseguer M Muriel L | 2010 | Hum Reprod2010，25，7： | 1 |
| 18 | Value of the sperm deoxyribonucleic acid fragmentation level, as measured by the sperm chromatin dispersion test, in the outcome of in vitro fertilization and intracytoplasmic sperm injection显示文摘 | Muriel L Garrido N Ferndndez JL | 2006 | Fertil Steril2006，85，2： | 1 |
| 19 | On the effectiveness of zeroinventory-ordering policies for the economic lot-sizing model with a class of piecewise linear cost structures显示文摘 | Chan L M A Muriel A Shen Z J | 2002 | Computers & Operations Research2002，50，： | 1 |
| 20 | Y chromosome microdeletions, sperm DNA fragmentation and sperm oxidative stress as causes of recurrent spontaneous abortion of unknown etiology显示文摘 | BELLVER J MESEGUER M MURIEL L | 2010 | Hum Reprod2010，25，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员