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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | A new method of measuring involute profile deviations of gear teeth显示文摘 | Munro R G | 1996 | Journal of Mechanical Engineering Science1996，210，： | 2 |
| 3 | The use of Gauss-Laguerre vector beams in STED microscopy显示文摘 | TOROK P MUNRO P R T | 2004 | Opt Express2004，12，15： | 1 |
| 4 | Aspects of the surface and bulk ni- tration of cellulose in nitric acid, nitric acid/water, and ni- tric acid/dichloromethane mixes 显示文摘 | Short R D Munro H S | 1990 | Journal of Applied Polymer Science1990，39，： | 1 |
| 5 | Determingtion of Sulfon-amide Residues in the Tissues of Food Animals Using Automated Precolumn Derivatization and Liquid Chromatography with Fluorescence Detection显示文摘 | Salisburk C D C Sweet J C Munro R | 2004 | J AOAC Int2004，87，5： | 1 |
| 6 | The impact of subsidies upon fisheries management and sustainability: The case of the North Atlantic 显示文摘 | MUNRO G SUMAILA U R | 2002 | Fish and Fisheries2002，3，： | 1 |
| 7 | An Hsp70-like protein in the ER:identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein显示文摘 | MUNRO S PELHAM H R | 1986 | Cell1986，46，： | 1 |
| 8 | Commerlcal Manila clam( Tapes philippinarum) culture in British Columbia, Canada: The effects of predator netting on intertidal sediment characteristics 显示文摘 | Munroe D McKinley R S | 2007 | Estuarine Coastal and Shelf Science2007，72，： | 1 |
| 9 | Marine natural prod- uets显示文摘 | Blunt J W Copp B R Munro M G H | 2004 | Nat Prod Rep2004，21，1： | 1 |
| 10 | Threshold criteria for incipient sediment motion on an inclined bedform in the presence of oscillating-grid turbulence显示文摘 | WAN MOHTAR W H M MUNRO R J | 2013 | Physics of Fluids2013，25，01： | 1 |
| 11 | An evaluation of the in vitro activity of piperacillin/tazobactam显示文摘 | Daley D Mulgrave L Munro R | 1996 | Pathology1996，28，2： | 1 |
| 12 | Game theory and the development of resourcemanagement policy显示文摘 | GORDON R MUNRO | 2009 | Environment and Development Economics2009，14，1： | 1 |
| 13 | A procedure for the safety evaluation of flavoring substances显示文摘 | MUNRO I C KENNEPOHL E KROES R | 1999 | Food and Chemical Toxicology1999，37，： | 1 |
| 14 | Observations on the use of rigid fixation for craniofacial deformities in infants and young children显示文摘 | Fearon J A Munro I R Bruce D A | 1995 | Plast Reconstr Surg1995，5，4： | 1 |
| 15 | Study of particle nucleation, flocculation, and growth in the emulsion -free polymerization of styrene in water intensity light scattering and photon correlation spectroscopy 显示文摘 | Munro D Goodall A R Wilkinson M C | 1979 | J Conoid Interface Sci1979，68，： | 1 |
| 16 | Systemic sepsis and intra venous devices ,a prospective survey显示文摘 | Collignon PJ Munro R Sorrell TC | 1984 | Med J Aust1984，141，6： | 1 |
| 17 | Complex formation by dithionate(V) ion显示文摘 | GREATREX R MUNRO D C | 1997 | J Chem Research1997，9495，： | 1 |
| 18 | Investigation of the effect of type 2 diabetes mellitus on subgingival plaque microbiota by high -throughput 16S rDNA pyrosequeneing 显示文摘 | Zhou M Rong R Munro D | 2013 | PLoS One2013，228，61： | 1 |
| 19 | Microstructure,mechanical properties and wear of Ni-Al-Fe alloys显示文摘 | Munroe P R George M Baker I | 2002 | Mater Sci Eng A2002，325，12： | 1 |
| 20 | Correlation of structural class with no observed effect levels: a proposal for establishing a threshold of concern 显示文摘 | MUNRO I C FORD R A KENNEPOHL E | 1996 | Food Chem Toxicol1996，34，9： | 1 |
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