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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Numerical analysis of electron beam lithography systems显示文摘 | Munro E Chu H C | 1982 | Optik1982，61，4： | 2 |
| 3 | Determingtion of Sulfon-amide Residues in the Tissues of Food Animals Using Automated Precolumn Derivatization and Liquid Chromatography with Fluorescence Detection显示文摘 | Salisburk C D C Sweet J C Munro R | 2004 | J AOAC Int2004，87，5： | 1 |
| 4 | Evening Primrose Oil and Treatment of Premenstrual Syndrome显示文摘 | Khoo S K Munro C Battistutta D | 1990 | The Medical Journal of Australia1990，153，4： | 1 |
| 5 | Exogenous manganous ion at millimolar levels rescues all known dioxygen-sensitive phenotypes of yeast lacking CuZnSOD显示文摘 | Sanchez RJ Srinivasan C Munroe WH | | 0，，08： | 1 |
| 6 | Chitin synthesis and fungal pathogenesis显示文摘 | Lenardon M D Munro C A Gow N A | 2010 | Curr Opin Microbiol2010，13，： | 1 |
| 7 | A procedure for the safety evaluation of flavoring substances显示文摘 | MUNRO I C KENNEPOHL E KROES R | 1999 | Food and Chemical Toxicology1999，37，： | 1 |
| 8 | Study of particle nucleation, flocculation, and growth in the emulsion -free polymerization of styrene in water intensity light scattering and photon correlation spectroscopy 显示文摘 | Munro D Goodall A R Wilkinson M C | 1979 | J Conoid Interface Sci1979，68，： | 1 |
| 9 | Detection of Lactobacillus, Pediococcus, Leuconostoc, and Weissellaspecies in human feces by using group-specific PCR primers anddenaturing gradient gel electrophoresis 显示文摘 | Walter J Hertel C Tannock GW Lis CM Munro K Hammes WP | 2001 | Appl Environ Microbiol2001，67，： | 1 |
| 10 | UV Studies of Tetrahedral Bonding in Diamondlike Amorphous Carbon显示文摘 | Merkulov V I Lannin J S Munro C H | 1997 | Physical Review Letters1997，78，25： | 1 |
| 11 | Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy 显示文摘 | Ali RR0 Sarra GM Stephens C Alwis MD Bainbridge JW Munro PM | 2000 | Nat Genet2000，25，3： | 1 |
| 12 | Complex formation by dithionate(V) ion显示文摘 | GREATREX R MUNRO D C | 1997 | J Chem Research1997，9495，： | 1 |
| 13 | Restocking and stock enhancement of marine invertebrate fisheries显示文摘 | Bell J D Rothlisberg P C Munro J L | 2005 | Adv Mar Biol2005，49，： | 1 |
| 14 | Oral Health and Care in the Intensive Care Unit:State of the Science显示文摘 | Munro C L Grap M J Ruth K | 2004 | Am J Crit Care2004，13，1： | 1 |
| 15 | Correlation of structural class with no observed effect levels: a proposal for establishing a threshold of concern 显示文摘 | MUNRO I C FORD R A KENNEPOHL E | 1996 | Food Chem Toxicol1996，34，9： | 1 |
| 16 | Information Technology Assessment and Ddoption:A Field Study显示文摘 | Huff S L Munro M C | 1985 | MIS Quarterly1985，9，4： | 1 |
| 17 | Fire retardant mechanism of aliphatic bromine compounds in polystyrene and polypropylene显示文摘 | Kaspersma J Doumen C Munro S | 2002 | Polym Degrad Stab2002，77，2： | 1 |
| 18 | Erythritol:an interpretive summary of biochemical,metabolic,toxicological and clinical data显示文摘 | Munro C Bernt W O Borzelleca J F | 1998 | Food and Chemical Toxicol1998，36，12： | 1 |
| 19 | Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient,glyphosate,for humans显示文摘 | WILLIAMS G M KROES R MUNRO I C | 2000 | Regulatory Toxicology and Pharmacology2000，31，： | 1 |
| 20 | Effect of back-rest elevation on the development of ventilator - associated pneu- monia显示文摘 | GRAP M J MUNRO C L HUMMEL R S | 2005 | Am J Crit Care2005，14，4： | 1 |
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