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| 1 | Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease显示文摘Emerging data have shown a close association between compositional changes in gut microbiota and the development of nonalcoholic fatty liver disease(NAFLD).The change in gut microbiota may alter nutritional absorption and storage.In addition,gut microbiota are a source of Toll-like receptor(TLR)ligands,and their compositional change can also increase the amount of TLR ligands delivered to the liver.TLR ligands can stimulate liver cells to produce proinflammatory cytokines.Therefore,the gut-liver axis has attracted much interest,particularly regarding the pathogenesis of NAFLD.The abundance of the major gut microbiota,including Firmicutes and Bacteroidetes,has been considered a potential underlying mechanism of obesity and NAFLD,but the role of these microbiota in NAFLD remains unknown.Several reports have demonstrated that certain gut microbiota are associated with the development of obesity and NAFLD.For instance,a decrease in Akkermansia muciniphila causes a thinner intestinal mucus layer and promotes gut permeability,which allows the leakage of bacterial components.Interventions to increase Akkermansia muciniphila improve the metabolic parameters in obesity and NAFLD.In children,the levels of Escherichia were significantly increased in nonalcoholic steatohepatitis(NASH)compared with those in obese control.Escherichia can produce ethanol,which promotes gut permeability.Thus,normalization of gut microbiota using probiotics or prebiotics is a promising treatment option for NAFLD.In addition,TLR signaling in the liver is activated,and its downstream molecules,such as proinflammatory cytokines,are increased in NAFLD.To data,TLR2,TLR4,TLR5,and TLR9 have been shown to be associated with the pathogenesis of NAFLD.Therefore,gut microbiota and TLRs are targets for NAFLD treatment. | Kouichi Miura Hirohide Ohnishi | 2014 | World Journal of Gastroenterology2014，20，23： | 78 |
| 2 | Multidisciplinary therapy for treatment of patients with peritoneal carcinomatosis from gastric cancer显示文摘There is no standard treatment for peritoneal carcinomatosis (PC) from gastric cancer.A novel multidisciplinary treatment combining bidirectional chemotherapy [neoadjuvant intraperitoneal-systemic chemotherapy protocol (NIPS)],peritonectomy,hyperthermic intraperitoneal chemoperfusion (HIPEC) and early postoperative intraperitoneal chemotherapy has been developed.In this article,we assess the indications,safety and eff icacy of this treatment,review the relevant studies and introduce our experiences.The aims of NIPS are stage reduction,the eradication of peritoneal free cancer cells,and an increased incidence of complete cytoreduction (CC-0) for PC.A complete response after NIPS was ob-tained in 15 (50%) out of 30 patients with PC.Thus,a signif icantly high incidence of CC-0 can be obtained in patients with a peritoneal cancer index (PCI) ≤ 6.Using a multivariate analysis to examine the survival benef it,CC-0 and NIPS are identified as significant indicators of a good outcome.However,the high morbidity and mortality rates associated with peritonectomy and perioperative chemotherapy make stringent patient selection important.The best indications for multidisciplinary therapy are localized PC (PCI≤6) from resectable gastric cancer that can be completely removed during a peritonectomy.NIPS and complete cytoreduction are essential treatment modalities for improving the survival of patients with PC from gastric cancer. | Yutaka Yonemura Ayman Elnemr Yoshio Endou Mitsumasa Hirano Akiyoshi Mizumoto Nobuyuki Takao Masumi Ichinose Masahiro Miura | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 27 |
| 3 | Compound Danshen injection improves endotoxin-induced microcirculatory disturbance in rat mesentery显示文摘AIM: To investigate the effect of compound Danshen injection on lipopolysaccharide (LPS)-induced rat mesenteric microcirculatory dysfunctions and the underlying possible mechanism by an inverted intravital microscope and high-speed video camera system. METHODS: LPS was continuously infused through the jugular artery of male Wistar rats at the dose of 2 mg/kg per hour. Changes in mesenteric microcirculation,such as diameters of arterioles and venules,velocity of RBCs in venules,leukocyte rolling,adhesion and emigration,free radicals released from post-capillary venules,FITC- albumin leakage and mast cell degranulation,were observed through an inverted intravital microscope assisted with CCD camera and SIT camera. Meanwhile,the expression of adhesion molecules CD11b/CD18 and the production of free radical in neutrophils,and the expression of intercellular adhesion molecule 1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs) were quantified by flow cytometry (FACS) in vitro. RESULTS: The continuous infusion with LPS resulted in a number of responses in microcirculation,including a significant increase in the positive region of venulestained with Monastral blue B,rolling and adhesion of leukocytes,production of oxygen radical in venular wall,albumin efflux and enhanced mast cell degranulation in vivo,all of which,except for the leukocyte rolling,were attenuated by the treatment with compound Danshen injection. Experiments performed in vitro further revealed that the expression of CD11b/CD18 and the production of oxygen free radical in neutrophils,and the expression of ICAM-1 in HUVECs were increased by exposure to LPS,and they were attenuated by compound Danshen injection. CONCLUSION: These results suggest that compound Danshen injection is an efficient drug with multi-targeting potential for improving the microcirculatory disturbance. | Jing-Yan Han Yoshinori Horie Soichiro Miura, Yasutada Akiba Jun Guo Dan Li Jing-Yu Fan Yu-Ying Liu Bai-He Hu Li-Hua An Xin Chang Man Xu De-An Guo Kai Sun Ji-Ying Yang Shu-Ping Fang Ming-Ji Xian Masahiro Kizaki Hiroshi Nagata Toshifumi Hibi | 2007 | World Journal of Gastroenterology2007，13，26： | 26 |
| 4 | Dynamic recrystallization and texture development during hot deformation of magnesium alloy AZ31显示文摘The dynamic recrystallization(DRX) and texture development, taking place during hot deformation of magnesium alloy AZ31 with a strong wire texture, were studied in compression at 673 K (0.73 Tm). Two kinds of samples were machined parallelly to the extruded and transverse directions of Mg alloy rods. New fine grains are evolved at original grain boundaries corrugated at low strains and develop rapidly in the medium range of strain, finally leading to a roughly full evolution of equiaxial fine grains. Kink bands are evolved at grain boundaries corrugated and also frequently in grain interiors at low strains. The boundary misorientations of kink band increase rapidly with increasing strain and approach a saturation value in high strain. The average size of the regions fragmented by kink band is almost the same as that of new grains evolved in high strain. These characteristics of new grain evolution process are not changed by the orientation of the samples, while the flow behaviors clearly depend on it. It is concluded that new grain evolution can be controlled by a deformation-induced continuous reaction, i.e. continuous dynamic recrystallization(DRX). The latter is discussed by comparing with conventional, i.e. discontinuous DRX. | 杨续跃 吉泽升 H. MIURA T. SAKAI | 2009 | 中国有色金属学会会刊:英文版2009，19，1： | 16 |
| 5 | The Phosphate Transporter PHT4;6 Is a Determinant of Salt Tolerance that Is Localized to the Golgi Apparatus of Arabidopsis显示文摘破坏 PHT4 的功能的插入变化;(At5g44370 ) 6 引起 NaCl 被主要的根的减少的生长根尖端描绘,提高的侧面的分叉,并且胀大的 Arabidopsis 幼苗的超敏性。变异的显型被蔗糖,然而并非由甘露糖醇的 equiosmolar 集中加重,并且在媒介由低无机的磷酸盐稀释了。蛋白质 PHT4; 6 属于分享重要顺序类似到哺乳动物的类型的 permeases 的主要 Facilitator 总科 -- 我 Pi transporters 和小囊的 glutamate transporters,并且是植物的通常认为的细胞内部的磷酸盐 transporters 的 PHT4 家庭的一个成员。PHT4; 6 本地化那 PHT4 到膜和运输研究显示的 Golgi; 6 便于 Pi 然而并非氯化物或无机的阴离子的选择运输。有显示根胀大的另外的异种的 Phenotypic 类似建议那 PHT4;在蛋白质 N-glycosylation 和房间的 6 可能的功能围生合成,它为盐忍耐是必要的。一起,我们的结果显示那 PHT4;从为再循环免除 glycosylation 的 Pi 的 Golgi lumenal 空间的 6 运输 Pi 处理。 | Beatriz Cubero Yuko Nakagawa Xing-Yu Jiang Ken-Ji Miura Fang Li Kashchandra G. Raghothama Ray A. Bressan Paul M. Hasegawa Jose M. Pardo | 2009 | Molecular Plant2009，2，3： | 15 |
| 6 | Eosinophilic gastroenteritis with cytomegalovirus infection in an immunocompetent child显示文摘A 3-year-old boy developed transient protein-losing gastroenteropathy associated with cytomegalovirus (CMV) infection. Both IgG and IgM antibodies to CMV were positive in a serologic blood test. Upper gastrointestinal endoscopy showed multiple erosions throughout the body of the stomach, without enlarged gastric folds. Histological examination of the biopsy specimens indicated eosinophilic gastroenteritis and CMV infection. The patient had complete resolution without specific therapy for CMV in four weeks. An allergic reaction as well as CMV infection played important roles in the pathogenesis of this case. | Junji Takeyama Daiki Abukawa Katsushi Miura | 2007 | World Journal of Gastroenterology2007，13，34： | 11 |
| 7 | 早胃的癌症用的程度的诊断灵活光谱成像颜色改进显示文摘 The demarcation line between the cancerous lesion and the surrounding area could be easily recognized with flexible spectral imaging color enhancement (FICE) system compared with conventional white light images. The characteristic f inding of depressed-type early gastric cancer (EGC) in most cases was revealed as reddish lesions distinct from the surrounding yellowish non-cancerous area without magnification. Conventional endoscopic images provide little information regarding depressed lesions located in the tangential line, but FICE produces higher color contrast of such cancers. Histological f indings in depressed area with reddish col- or changes show a high density of glandular structure and an apparently irregular microvessel in intervening parts between crypts, resulting in the higher color con- trast of FICE image between cancer and surrounding area. Some depressed cancers are shown as whitish lesion by conventional endoscopy. FICE also can pro- duce higher color contrast between whitish cancerous lesions and surrounding atrophic mucosa. For nearly flat cancer, FICE can produce an irregular structuralpattern of cancer distinct from that of the surrounding mucosa, leading to a clear demarcation. Most elevated-type EGCs are detected easily as yellowish lesions with clearly contrasting demarcation. In some cases, a partially reddish change is accompanied on the tumor surface similar to depressed type cancer. In addition, the FICE system is quite useful for the detection of minute gastric cancer, even without magnif ication. These new contrasting images with the FICE system may have the potential to increase the rate of detection of gastric cancers and screen for them more effectively as well as to determine the extent of EGC. | Hiroyuki Osawa Hironori Yamamoto Yoshimasa Miura Mitsuyo Yoshizawa Keijiro Sunada Kiichi Satoh Kentaro Sugano | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，8： | 11 |
| 8 | 以低阶煤及生物质热溶萃取物为前驱体制备炭纤维(英文)显示文摘采用热溶剂萃取法从低阶煤和生物质废弃物中获得了一种萃取物,此萃取物收率高达61%,在100℃左右开始软化。然后以此萃取物为前驱体,通过热熔纺丝-有机溶剂处理-缓慢氧化-炭化的方法制得了炭纤维。通过元素分析、傅里叶变换红外光谱(FTIR)、电子显微镜(SEM)等对炭纤维的形貌结构、物相组成等进行了表征分析,结果表明此炭纤维的基本性质与商业炭纤维相似。本方法是一种具有一定实际可行性的炭纤维制备新途径。 | 李显 朱贤青 Kenshiro Okuda 张宗 Ryuichi Ashida 姚洪 Kouichi Miura | 2017 | 新型炭材料2017，32，1： | 10 |
| 9 | Immunological Effects of Silica and Asbestos显示文摘Silicosis patients(SILs) and patients who have been exposed to asbestos develop not only respiratory diseases but also certain immunological disorders. In particular,SIL sometimes complicates autoimmune diseases such as systemic scleroderma,rheumatoid arthritis(known as Caplan syndrome) ,and systemic lupus erythematoses. In addition,malignant complications such as lung cancer and malignant mesothelioma often occurr in patients exposed to asbestos,and may be involved in the reduction of tumor immunity. Although silica-induced disorders of autoimmunity have been explained as adjuvant-type effects of silica,more precise analyses are needed and should reflect the recent progress in immunomolecular findings. A brief summary of our investigations related to the immunological effects of silica/asbestos is presented. Recent advances in immunomolecular studies led to detailed analyses of the immunological effects of asbestos and silica. Both affect immuno-competent cells and these effects may be associated with the pathophysiological development of complications in silicosis and asbestos-exposed patients such as the occurrence of autoimmune disorders and malignant tumors,respectively. In addition,immunological analyses may lead to the development of new clinical tools for the modification of the pathophysiological aspects of diseases such as the regulation of autoimmunity or tumor immunity using cell-mediated therapies,various cytokines,and molecule-targeting therapies. In particular,as the incidence of asbestos-related malignancies is increasing and such malignancies have been a medical and social problem since the summer of 2005 in Japan,efforts should be focused on developing a cure for these diseases to eliminate nationwide anxiety. | Takemi Otsuki Megumi Maeda Shuko Murakami Hiroaki Hayashi Yoshie Miura Masayasu Kusaka Takashi Nakano Kazuya Fukuoka Takumi Kishimoto Fuminori Hyodoh Ayako Ueki Yasumitsu Nishimura | 2007 | Cellular & Molecular Immunology2007，4，4： | 9 |
| 10 | An easier method for performing a pancreaticojejunostomy for the soft pancreas using a fast-absorbable suture显示文摘AIM: To clarify the usefulness of a new method for performing a pancreaticojejunostomy by using a fast-absorbable suture material irradiated polyglactin 910, and a temporary stent tube for a narrow pancreatic duct with a soft pancreatic texture.METHODS: Among 63 consecutive patients with soft pancreas undergoing a pancreaticoduodenectomy from 2003 to 2006, 35 patients were treated with a new reconstructive method. Briefly, after the pancreatic transaction, a stent tube was inserted into the lumen of the pancreatic duct and ligated with it by a fast-absorbable suture. Another tip of the stent tube was introduced into the intestinal lumen at the jejunal limb, where a purse-string suture was made by another fast-absorbable suture to roughly fix the tube. The pancreaticojejunostomy was completed by ligating two fast-absorbable sutures to approximate the ductal end and the jejunal mucosa, and by adding a rough anastomosis between the pancreatic parenchyma and the seromuscular layer of the jejunum. The initial surgical results with this method were retrospectively compared with those of the 28 patients treated with conventional duct-to-mucosa anastomosis.RESULTS: The incidences of postoperative morbidity including pancreatic fistula were comparable between the two groups (new; 3%-17% vs conventional; 7%-14% according to the definitions). There was no mortality and re-admission. Late complications were also rarely seen.CONCLUSION: A pancreaticojejunostomy using an irradiated polyglactin 910 suture material and a temporary stent is easy to perform and is feasible even in cases with a narrow pancreatic duct and a normal soft pancreas. | Kenichi Hakamada Shunji Narumi Yoshikazu Toyoki Masaki Nara Kenosuke Ishido Takuya Miura Norihito Kubo Mutsuo Sasaki | 2008 | World Journal of Gastroenterology2008，14，7： | 9 |
| 11 | Grain size and texture changes of magnesium alloy AZ31 during multi-directional forging显示文摘Grain size and texture changes of magnesium alloy AZ31 were studied in multidirectional forging(MDF) under decreasing temperature conditions.MDF was carried out up to large cumulative strains of 4.8 with changing the loading direction during decrease in temperature from pass to pass.MDF can accelerate the uniform development of fine-grained structures and increase the plastic workability at low temperatures.As a result,the MDFed alloy shows excellent higher strength as well as moderate ductility at room temperature even at the grain size below 1μm.Superplastic flow takes place at 423 K and depends on the anisotropy of MDFed samples.The mechanisms of strain-induced fine-grained structure development and of the plastic deformation were discussed in detail. | 杨续跃 孙争艳 XING 3Jie MIURA Hiromi SAKAI Taku | 2008 | 中国有色金属学会会刊:英文版2008，18，A01： | 9 |
| 12 | 根据血压等级确定脑卒中和冠状动脉粥样硬化性心脏病死亡的终生风险:日本EPOCH(观察队列的心血管预防证据)研究显示文摘在亚洲人群中.很少研究关注根据血压分类确定脑卒中和冠状动脉粥样硬化性心脏病(coronary heartdisease,CHD)的终生风险。该研究旨在用一个包含个体参与者数据的荟萃分析大数据库来评估它。该荟萃分析纳入来源于13个队列的107 737名日本人(男性占42.4%,平均年龄55.1岁)。在平均(15.2±5.3)年(1 559 136人年)的随访期.1922人死于脑卒中,913人死于CHDO研究者在调整其他死亡危险因素后估计风险。 | 陈嘉睿(译) 练桂丽(审校) Satoh M Ohkubo T Asayama K Murakami Y Sugiyama D Yamada M Saitoh S Sakata K Irie F Sairenchi T Ishikawa S Kiyama M Ohnishi H Miura K Imai Y Ueshima H Okamura T EPOCH-JAPAN research group | 2019 | 中华高血压杂志2019，27，4： | 9 |
| 13 | 玉米须的降血脂作用显示文摘 | Miura T | 2006 | 国际中医中药杂志2006，28，2： | 9 |
| 14 | Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer显示文摘AIM:To study how lymph node metastasis(LNM) risk is stratified in undifferentiated-type early gastric cancer(undiff-EGC) dependent on combinations of risk factors.METHODS:Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined retrospectively.Using clinicopathological factors of patient age,location,size,an endoscopic macroscopic tumor form,ulceration,depth,histology,lymphatic involvement(LI) and venous involvement(VI),LNM risk was examined and stratified by conventional statistical analysis and datamining analysis.RESULTS:LNM was positive in 44 of 567 cases(7.8%).Univariate analysis revealed > 2 cm,protrusion,submucosal(sm),mixed type,LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate analysis.In preoperatively evaluable factors excluding LVI,sm and > 2 cm were independent factors.According to the depth and size,cases were categorized into the low-risk group [m and ≤ 2 cm,0%(LNM incidence)],the moderaterisk group(m and > 2 cm,5.6%; and sm and ≤ 2 cm,6.0%),and the high-risk group(sm and > 2 cm,19.3%).On the other hand,LNM occurred in 1.4% in all LI-negative cases,greatly lower than 28.2% in all LI-positive cases,and LNM incidence was low in LInegative cases even in the moderate- and high-risk groups.CONCLUSION:LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size postoperatively.Among these factors,LI was the most significantly correlated factor. | Yukiko Asakawa Masahiko Ohtaka Shinya Maekawa Mitsuharu Fukasawa Yasuhiro Nakayama Tatsuya Yamaguchi Taisuke Inoue Tomoyoshi Uetake Minoru Sakamoto Tadashi Sato Yoshihiko Kawaguchi Hideki Fujii Kunio Mochizuki Masao Hada Toshio Oyama Tomotaka Yasumura Kosaku Omata Atsushi Nishiyama Keiichi Naito Hideo Hata Yoshiaki Haba Kazuyuki Miyata Haruhisa Saitoh Yoichi Yamadera Kazuo Miura Akira Kawaoi Tohru Abe Hajime Tsunoda Yuji Honda Masayuki Kurosaki Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，9： | 8 |
| 15 | 膳食中钠(盐)与血压的关系及其他膳食因素可能的调节作用显示文摘现有资料表明,膳食钠(盐)与血压直接相关。以往大多数研究结果来自缺乏膳食数据的研究;因此,这种钠-血压关系是否受其他膳食因素调节尚不清楚。国际宏量/微量营养素和血压研究(international study on macro/micronutrients and blood pressure,INTERMAP)结果显示,在控制多种非膳食因素情况下,年龄40~59岁的男性和女性4680人(中国、日本、英国和美国的17个人口样本)的血压与24h尿钠排泄和尿钠/钾直接相关。 | 刘莉 叶鹏 Stamler J Chan Q Daviglus ML Dyer AR Van Horn L Garside DB Miura K Wu Y Ueshima H Zhao L Elliott P INTERMAP Research Group | 2018 | 中华高血压杂志2018，26，4： | 8 |
| 16 | Recrystallization behaviour of fine-grained magnesium alloy after hot deformation显示文摘Annealing behaviors of hot-deformed magnesium alloy AZ31 were studied at temperatures from 300 to 673 K by optical and SEM/EBSD metallographic observation. Temperature dependence of the average grain size(D) is categorized into three temperature regions, i.e. an incubation period for grain growth, rapid grain coarsening, and normal grain growth. The number of fine grains per unit area, however, is reduced remarkably even in incubation period. This leads to grain coarsening taking place continuously in the whole temperature regions. In contrast, the deformation texture scarcely changes even after full annealing at high temperatures. It is concluded that the annealing processes operating in hot-deformed magnesium alloy with continuous dynamic recrystallized grain structures can be mainly controlled by grain coarsening accompanied with no texture change, that is, continuous static recrystallization. | 杨续跃 H. Miura T. Sakai | 2007 | 中国有色金属学会会刊:英文版2007，17，6： | 8 |
| 17 | Microstructure and mechanical properties of AZ61 Mg alloy prepared by multi directional forging显示文摘AZ61Mg alloy was multi directionally forged(MDFed) during decreasing temperature condition from 643 K to 483 K at a true strain rate of 3×10-3 s-1 up to cumulative strain of∑△ε=4.0 at maximum.A pass strain of△ε=0.8 was employed.While average grain size decreased gradually with increasing cumulative strain,the evolution of fine-grained structure strongly depended on the MDF temperature.Under the condition where the temperature was higher than the most adequate one,grain coarsening partially took place during MDF.In contrast,at lower temperature,inhomogeneous microstructure composed of the initial coarse and newly appeared fine grains was evolved.After straining over∑△ε=3.2(i.e.,over 4 passes of MDF) ,equiaxed ultrafine grains(UFGs) having average size of about and lower than 1μm were uniformly evolved.While the MDFed alloy to∑△ε=4.0 possessed relatively high hardness of HV 99,and it accepted further about 20%cold rolling almost without cracking.Because of the superior formability of the UFGed AZ61Mg alloy,the hardness was further easily raised to HV 120 by following cold rolling. | H. MIURA G. YU X. YANG T. SAKAI | 2010 | Transactions of Nonferrous Metals Society of China2010，20，7： | 7 |
| 18 | Endoscopic submucosal dissection for early esophageal neoplasms using the stag beetle knife显示文摘AIM To determine short-and long-term outcomes of endoscopic submucosal dissection(ESD) using the stag beetle(SB) knife, a scissor-shaped device.METHODS Seventy consecutive patients with 96 early esophageal neoplasms, who underwent ESD using a SB knife at Kure Medical Center and Chugoku Cancer Center, Japan, between April 2010 and August 2016, were retrospectively evaluated. Clinicopathological characteristics of lesions and procedural adverse events were assessed. Therapeutic success was evaluated on the basis of en bloc, histologically complete, and curative or non-curative resection rates. Overall and tumor-specific survival, local or distant recurrence, and 3-and 5-year cumulative overall metachronous cancer rates were also assessed.RESULTS Eligible patients had dysplasia/intraepithelial neoplasia(22%) or early cancers(squamous cell carcinoma, 78%). The median procedural time was 60 min and on average, the lesions measured 24 mm in diameter, yielding 33-mm tissue defects. The en bloc resection rate was 100%, with 95% and 81% of dissections deemed histologically complete and curative, respectively. All procedures were completed without accidental incisions/perforations or delayed bleeding. During follow-up(mean, 35 ± 23 mo), no local recurrences or metastases were observed. The 3-and 5-year survival rates were 83% and 70%, respectively, with corresponding rates of 85% and 75% for curative resections and 74% and 49% for noncurative resections. The 3-and 5-year cumulative rates of metachronous cancer in the patients with curative resections were 14% and 26%, respectively.CONCLUSION ESD procedures using the SB knife are feasible, safe, and effective for treating early esophageal neoplasms, yielding favorable short-and long-term outcomes. | Toshio Kuwai Toshiki Yamaguchi Hiroki Imagawa Ryoichi Miura Yuki Sumida Takeshi Takasago Yuki Miyasako Tomoyuki Nishimura Sumio Iio Atsushi Yamaguchi Hirotaka Kouno Hiroshi Kohno Sauid Ishaq | 2018 | World Journal of Gastroenterology2018，24，15： | 7 |
| 19 | Overview of the radiometric and biophysical performance of the MODIS vegetation indices显示文摘 | A Huete K Didan T Miura E.P Rodriguez X Gao L.G Ferreira | 2002 | Remote Sensing of Environment2002，，1： | 6 |
| 20 | Short-term effects of di-(2-ethylhexyl) phthalate on testes,liver, kidneys and pancreas in mice显示文摘瞄准:决定 di-(2-ethylhexyl ) 的生物化学的效果在生精的上皮的退化的过程的白天 10 上的睾丸,肝,肾和胰上的 phthalate (DEHP ) 。方法:包含 2% DEHP 的食谱被给男 Crlj : CD1 (ICR ) 老鼠 for10 天。DEHP 的剂量是 0.90 ± 0.52 mg/mouse/day。他们的睾丸,肝,肾 andpancreata 为察觉被检验单音 --(2-ethylhexyl ) phthalate (MEHP ) ,氮氧化物(NOx ) 生产了由每氮的氧化物的氧化(没有) 与自由激进分子,和类脂化合物一起每自由激进分子的链反应导致的氧化。结果:组织学的观察和浆液分析显示出严重 spermatogenic 骚乱, Leydig 房间机能障碍,肝机能障碍和脱水的存在。出人意料地,在睾丸的 MEHP 的集中在肝与那相比是极其低的。然而,在睾丸的 NOx 的集中象肝的集中一样高。而且,免费导致激进分子的类脂化合物组织化学地在睾丸然而并非在肝每氧化被检测。结论:结果显示阴囊的纸巾的高敏感引起到传播 MEHP 的 MEHP 而非特定的累积或举起进睾丸的那导致 DEHP 的 aspermatogenesisis。 | Yumi Miura Munekazu Naito Maira Ablake Hayato Terayama Shuang-Qin Yi Ning Qu Lin-Xian Cheng Shigeru Suna Fumihiko Jitsunari Masahiro Itoh | 2007 | Asian Journal of Andrology2007，9，2： | 6 |
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