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| 1 | Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice显示文摘BACKGROUND Non-alcoholic fatty liver disease (NAFLD) has become an epidemic largely due to the worldwide increase in obesity. While lifestyle modifications and pharmacotherapies have been used to alleviate NAFLD, successful treatment options are limited. One of the main barriers to finding safe and effective drugs for long-term use in NAFLD is the fast initiation and progression of disease in the available preclinical models. Therefore, we are in need of preclinical models that (1) mimic the human manifestation of NAFLD and (2) have a longer progression time to allow for the design of superior treatments. AIM To characterize a model of prolonged high-fat diet (HFD) feeding for investigation of the long-term progression of NAFLD. METHODS In this study, we utilized prolonged HFD feeding to examine NAFLD features in C57BL/6 male mice. We fed mice with a HFD (60% fat, 20% protein, and 20% carbohydrate) for 80 wk to promote obesity (Old-HFD group, n = 18). A low-fat diet (LFD)(14% fat, 32% protein, and 54% carbohydrate) was administered for the same duration to age-matched mice (Old-LFD group, n = 15). An additional group of mice was maintained on the LFD (Young-LFD, n = 20) for a shorter duration (6 wk) to distinguish between age-dependent and age-independent effects. Liver, colon, adipose tissue, and feces were collected for histological and molecular assessments.RESULTS Prolonged HFD feeding led to obesity and insulin resistance. Histological analysis in the liver of HFD mice demonstrated steatosis, cell injury, portal and lobular inflammation and fibrosis. In addition, molecular analysis for markers of endoplasmic reticulum stress established that the liver tissue of HFD mice have increased phosphorylated Jnk and CHOP. Lastly, we evaluated the gut microbial composition of Old-LFD and Old-HFD. We observed that prolonged HFD feeding in mice increased the relative abundance of the Firmicutes phylum. At the genus level, we observed a significant increase in the abundance of Adercreutzia, Coprococcus, Dorea, and Ruminococcus and decreased relative abundance of Turicibacter and Anaeroplasma in HFD mice. CONCLUSION Overall, these data suggest that chronic HFD consumption in mice can mimic pathophysiological and some microbial events observed in NAFLD patients. | Kandy T Velázquez Reilly T Enos Jackie E Bader Alexander T Sougiannis Meredith S Carson Ioulia Chatzistamou James A Carson Prakash S Nagarkatti Mitzi Nagarkatti E Angela Murphy | 2019 | World Journal of Hepatology2019，11，8： | 6 |
| 2 | Functional states of resident vascular stem cells and vascular remodeling显示文摘最近的证据显示脉管的干细胞(VSC ) 的不同类型住在动脉和静脉的墙壁的层以内。这些居民 VSC 的精确身份仍然是不清楚的;通常,出生后的 vasculature 包含 multilineage 干细胞和脉管的房间可以参予脉管的修理和损害形成的系特定的祖先 / 茎房间。然而,内在的机制遗体糟糕理解。在这评论,我们总结潜在的分子的机制,它可以控制居民 VSC 的静止和激活并且加亮居民 VSC 的微分状态直接被连接到脉管的修理或损害形成的一个观点。 | Desiree F. Leach Mitzi Nagarkatti Prakash Nagarkatti Taixing Cui | 2015 | Frontiers in Biology2015，10，5： | 2 |
| 3 | Organic- Inorganic Electronics显示文摘 | Mitzi D B Chondroudis K Kagan C R | 2001 | IBM J RES& DEV2001，45，1： | 2 |
| 4 | Thin Film Deposition of Organic- Inorganic Hybrid Materials Using a Single Source Thermal Ablation Technique显示文摘 | Mitzi D B Prikas M T Chondroudis K | 1999 | Chem Mater1999，11，： | 2 |
| 5 | Organic- Inorganic Hybrid Materials as Semiconducting Channels in Thin- Film Field- Effect Transistors显示文摘 | Kagan C R Mitzi D B Dimitrakopoulos C D | 1999 | Science1999，286，10： | 2 |
| 6 | Templating and structural engineering in organic- inorganic perovskites显示文摘 | Mitzi D B | 2001 | J Chem Soc2001，112，： | 2 |
| 7 | Beyond 11% Efficiency: Characteristics of State‐of‐the‐Art Cu2ZnSn(S,Se)4 Solar Cells显示文摘 | Teodor K. Todorov Jiang Tang Santanu Bag Oki Gunawan Tayfun Gokmen Yu Zhu David B. Mitzi | 2012 | Adv. Energy Mater2012，，： | 2 |
| 8 | Intercalated organic-inorganic perovskites stabilized by flouroaryl-aryl interactions 显示文摘 | David B Mitzi David R Medeiros Patrick R L Malentant | 2002 | Inorg Chem2002，41，： | 1 |
| 9 | Organic-Inorganic Hybrid Materials as Semiconducting Channels in Thin-Film Field-Effect Transistors显示文摘 | Kagan C R Mitzi D B Dimitrakopoulos C D | 1999 | Science1999，286，： | 1 |
| 10 | Thin-Film Deposition of Organic-Inorganic Hybrid Materials 显示文摘 | David B Mitzi | 2001 | Chem Mater2001，13，： | 1 |
| 11 | Effect of thermal annealing on the optical and morphological properties of (AETH) PbX4 ( X = Br, I) perovskite films prepared using single source thermal ablation 显示文摘 | Konstantinos Chondroudis David B Mitzi Phillip Brock | 2000 | Chem Mater2000，12，： | 1 |
| 12 | Solution-Processed Inorganic Semiconductors显示文摘 | Mitzi David B | 2004 | J MaterChem2004，14，： | 1 |
| 13 | Solution-Processed Inorganic Semiconductors 显示文摘 | Mitzi D B | 2004 | J Mater Chem2004，14，： | 1 |
| 14 | Semicondueting perovskites (2-XC6H4 C2 H4 NH3 ) 2 SnI4 ( X = F, Cl, Br) sterie interaction between the organic and inorganic layers 显示文摘 | Zhengtao Xu David B Mitzi Christos D Dimitrakopoulos | 2003 | Inorg Chem2003，42，： | 1 |
| 15 | Structurally tailored organic-inorganic perovskites: Optical properties and solution-processed channel material for thin-film transistors显示文摘 | David B Mitzi Christos D Dimitrakopoulos Laura L Kosbar | 2001 | Chem Mater2001，13，： | 1 |
| 16 | Synthesis and characterization of organic-inorganic perovskite thin films prepared using a versatile two-step dipping technique显示文摘 | Liang K Mitzi D B Prikas M T | 1998 | Chem Mater1998，10，： | 1 |
| 17 | High-Efficiency Solar Cell with Earth-Abundant Liquid-Processed Absorber显示文摘 | Todorov T K Reuter K B Mitzi D B | 2010 | Advanced Materials2010，22，： | 1 |
| 18 | A layered solution crystal growth technique and the crystal structure of (C6H5 C2H4NH3 )2 PbCl4 显示文摘 | David B Mitzi | 1999 | Journal of Solid State Chemistry1999，145，： | 1 |
| 19 | Solvent Properties of Hydra- zine in the Preparation of Metal Chalcogenide Bulk Materials and Films显示文摘 | YUAN M MITZI D B | 2009 | Dalton Trans2009，31，： | 1 |
| 20 | Immune stimulating activity of two new chitosan containing adjuvant formulations显示文摘 | Peter GS Mitzi LM | 2001 | Vaccine2001，19，： | 1 |
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