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| 1 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 2 | Galectin-3 possible involvement in antipsychotic-induced metabolic changes of schizophrenia:A minireview显示文摘Recently,specific immunometabolic profiles have been postulated in patients with schizophrenia,even before full-blown disease and independent of antipsychotic treatment.Proteomic profiling studies offer a promising potential for elucidating the cellular and molecular pathways that may be involved in the onset and progression of schizophrenia symptoms,and co-occurrent metabolic changes.In view of all this,we were intrigued to explore galectin-3(Gal-3)as a glycan,and in our previous study,we measured its elevated levels in remission of schizophrenia.The finding may be a consequence of antipsychotic treatment and may have an impact on the onset of inflammation,the development of obesity,and the presumed cognitive changes in schizophrenia.In the animal study,it was shown that downregulation of Gal-3 was beneficial in insulin regulation of obesity and cognitive preservation.Strategies involving plasma exchange are discussed in this review,particularly in the context of Gal-3 elimination. | Milica M Borovcanin Katarina Vesic Milena Jovanovic Natasa R Mijailovic | 2021 | World Journal of Diabetes2021，12，10： | 4 |
| 3 | Glycolyzed poly (ethylene terephthalate) waste and castor oil - based polyols for waterborne polyurethane adhesives containing hexamethoxymethyl melamine显示文摘 | SUZANA M C IVAN S R MILENA M | 2015 | Progress in Organic Coatings2015，78，： | 1 |
| 4 | The application of Scanning Electronic Microscopy:The study of the surface of the upper layers of dyed polyester fibre samples in the ostacet yellow E-LSR显示文摘 | MILENA N M MILOVAN M P ALEKSANDRA R Z | 2004 | FACTA Universitis ( Physics Chemistry and Technology )2004，3，1： | 1 |
| 5 | Comparison of the hemostatic effects of a levonorgestrel-releasing intrauterine system and leuprolide acetate in women with endometriosis : A' randomized clinical trial 显示文摘 | Erciliene M Milena B Rui AF | 2014 | Thromb Res2014，134，6： | 1 |
| 6 | DNA damage and apoptosis in the mussel Mytilus galloprovincialis显示文摘 | Milena M Nevenka B Zeljko J | 2002 | Marine Environmental Research2002，53，： | 1 |
| 7 | Solitary gastric recur- rence from ovarian carcinoma:A case report and literature review 显示文摘 | Milena P Natalina M Claudia M | 2006 | Surg Oncol2006，15，： | 1 |
| 8 | The effect of ehitosan coating on the quality and nutraceutical traits of sweet cherry during post- harvest life~显示文摘 | MILENA P FEDERICA S SILVIA P M | 2015 | Food and/3ioproeess Technology2015，8，2： | 1 |
| 9 | Maintenance therapy in NSCLC: why to whom which agent? 显示文摘 | Novello S Milena M Tiseo M | 2011 | J Exp Clin Cancer Res2011，30，： | 1 |
| 10 | Lung Ultrasound-Implemented Diagnosis of Acute Decompensated Heart Failure in the ED显示文摘 | Emanuele Pivetta Alberto Goffi Enrico Lupia Maria Tizzani Giulio Porrino Enrico Ferreri Giovanni Volpicelli Paolo Balzaretti Alessandra Banderali Antonello Iacobucci Stefania Locatelli Giovanna Casoli Michael B. Stone Milena M. Maule Ileana Baldi Franco M | 2015 | Chest2015，，： | 1 |
| 11 | The application of Scanning Electronic Microscopy:The study of the surface of the upper layers of dyed polyester fibre samples in the ostacet yellow E-L5R,FACTA Universities显示文摘 | Milena N M Milovan M P Aleksandra R Z | 2004 | Physics Chemistry and Technology2004，3，1： | 1 |
| 12 | Using instruction block signatures to counter code injection attacks 显示文摘 | MILENA M ALEKSANDAR M EMIL J | | ACM Sigarch Computer Architecture News0，3，1： | 1 |
| 13 | The waterborne polyurethane dispersions based on polycarbonate diol: Effect of ionic content 显示文摘 | Cakic S M Milena Ristic S I | 2013 | Materials Chemistry and Physics2013，38，1： | 1 |
| 14 | The ever changing face of digital curation: introduction to the special issue on digital curation 显示文摘 | Milena D Wendy M D | 2015 | Archival Science2015，，3： | 1 |
| 15 | Pro-inflammatory effects of metals in persons and animals exposed to tobacco smoke显示文摘 | Halina M Milena S Magdalena D | 2015 | Journal of Trace Elements in Medicine and Biology2015，，29： | 1 |
| 16 | Glycolyzed products from PET waste and their application in synthesis of polyurethane dispersions 显示文摘 | SUZANA M C IVAN S R MILENA M C | 2012 | Progress in Organic Coatings2012，74，： | 1 |
| 17 | DNA damage and apoptosis in the mussel mytilus galloprovincialis显示文摘 | MILENA M NEVENKA B ZELJKO J | 2002 | Marine Environmental Research2002，53，： | 1 |
| 18 | Molecular typing of Scaphylococcus aureus isolated from Italian dairy products on the basis of coagulase gene polymorphism,multiple-locus vari- able-number tandem-repeat and toxin genes 显示文摘 | Stefano M Milena B Roberta L | 2008 | J Dairy Res2008，75，4： | 1 |
| 19 | On-line adaptive clustering for process monitoring and fault detection显示文摘 | Milena P Rapaic M R Jelicic Z D | 2012 | Expert System with Applications2012，39，10： | 1 |
| 20 | Novel antibacterial fibers of quaternized chitosan and Poly(vinyl Pyrrolidone)prepared by electrospinning显示文摘 | Milena I Nevena M lliya R | 2007 | European polymer Journal2007，，43： | 1 |
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