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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | Oncocytic papillary re- nal cell carcinoma:a clinicopathologic, immunohistochemi- cal, uhrastructural, and interphase cytogenetic study of 12 cases 显示文摘 | Ondrej H Matteo B Michal M | 2006 | Anna Diagn Pathol2006，10，： | 1 |
| 3 | A symbolic-numerical approach to ap- proximate parameterizations of space curves using graphs of critical points显示文摘 | MICHAL B MIROSLAV L | 2013 | Journal of Computational and Applied Mathematics2013，242，： | 1 |
| 4 | Relationship between Natriuretic Peptides and Residual Diuresis duringContinuous Hemodiafiltration显示文摘 | Martin B Antonin J Michal K | | 0，，： | 1 |
| 5 | Chemical stabilization of Bacillus subtilis α-anaylase by modification with D-glucono-8-1actone显示文摘 | SEFAN J STEAN B MICHAL R | 1992 | Biotechnology Techniques1992，6，2： | 1 |
| 6 | 3D visualization of tomographic volume data using the generalized voxel model显示文摘 | Karl H H Michale B Andreas P | 1990 | The Visual Computer1990，6，1： | 1 |
| 7 | Hemodynamic and cate- cholamine response to tracheal intubation : direct laryngoscopy com- pared with fiberoptic intubation 显示文摘 | Michal B Avishai Z Avital G | 2003 | J Clin Anesth2003，15，8： | 1 |
| 8 | The light-hyperresponsive high pigment-2dg mutation of tomato: alterations in the fruit metabolome 显示文摘 | Raoul J B Ric de C H V Michal L | 2005 | New Phytologist2005，166，： | 1 |
| 9 | Investigation on the switching behavior of AgSnO2 material in commercial contactors 显示文摘 | Mayer U Michal R | 1985 | IEEE Trans Comp1985，8，1： | 1 |
| 10 | Free fatty acids repress the GLUT4 gene expression in cardiac muscle via novel response ele- ments显示文摘 | Michal A Chava H Fabiana B Y | 2005 | J Biol Chem2005，280，34： | 1 |
| 11 | Bitumen and heavy oil rheological properties: reconciliation with viscosity measurements显示文摘 | Bazyleva Ala B MD Anwarul Hasan Michal Fulem | 2010 | Journal of Chemical & En- gineering Data2010，55，3： | 1 |
| 12 | Interaction of conjuated dienoic dervatives of linoleic with β-carotence on cellular host defence显示文摘 | Michal J J Chew B P Schultz T D | 1992 | FASEBJ1992，6，： | 1 |
| 13 | Peroxisone proliferator - activated receptors and cancers : complex stories 显示文摘 | Michalic L Desvergne B Wahli W | 2004 | Nat Rev Cancer2004，4，1： | 1 |
| 14 | Use of DNA and peptide nucleic acid molecular beacons for detection and quantification of rRNA in solution and in whole cells显示文摘 | Xi C W Michal B Stephen A B | | 0，，09： | 1 |
| 15 | Interaction of conjugated dienoic derivatives of linoleic acid with β-carotene on cellular host defense显示文摘 | Michal J J Chew B P Schultz T D | 1992 | FASEB J1992，6，： | 1 |
| 16 | Intrauterine inflammation,insufficient to induce parturition,still evokes fetal and neonatal brain injury显示文摘 | Michal AE Amy GB Kelsey B | | 0，，6： | 1 |
| 17 | Confinement effects on polymer crystallization: From dnoplets to alumina nanopores 显示文摘 | MICHALL R M LEZAK L B MIJANGOS C | 2013 | Polymer2013，54，： | 1 |
| 18 | The TIR domain of TIR-NB-LRR resistance proteins is a signaling domain involved in cell death in-duction显示文摘 | Michal R Doris B Jonathan D | 2009 | Mol Plant-Microbe Interact2009，22，2： | 1 |
| 19 | Effects of Ca^2+-Ionophore A23187 and calmodulin antagonists on regulatory mechanisms of glycolysis and cell viability of NIH-3T3 fibrohlasts显示文摘 | Michal A S Rivka B | 1999 | Mol Gen Metab1999，67，4： | 1 |
| 20 | On the relationship between encapsulated ultrasound contrast agent and pressure显示文摘 | Dan A Michal S Elina B | 2005 | Ultrasound Med Biol2005，31，5： | 1 |
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