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| 1 | Impact of sodium glucose cotransporter-2 inhibitors on liver steatosis/fibrosis/inflammation and redox balance in non-alcoholic fatty liver disease显示文摘BACKGROUND Sodium glucose cotransporter-2 inhibitors(SGLT2-I)are the most recently approved drugs for type 2 diabetes(T2D).Recent clinical trials of these compounds reported beneficial cardiovascular(CV)and renal outcomes.A major cause of vascular dysfunction and CV disease in diabetes is hyperglycemia associated with inflammation and oxidative stress.Pre-clinical studies demonstrated that SGLT2-I reduce glucotoxicity and promote anti-inflammatory effects by lowering oxidative stress.AIM To investigate the effects of SGLT2-I on markers of oxidative stress,inflammation,liver steatosis,and fibrosis in patients of T2D with non-alcoholic fatty liver disease(NAFLD).METHODS We referred fifty-two consecutive outpatients treated with metformin monotherapy and exhibiting poor glycemic control to our centre.We introduced the outpatients to an SGLT2-I(dapagliflozin,empagliflozin,or canagliflozin;n=26)or a different hypoglycemic drug[other glucose-lowering drugs(OTHER),n=26].We evaluated circulating interleukins and serum hydroxynonenal(HNE)-or malondialdehyde(MDA)-protein adducts,fatty liver index(FLI),NAFLD fibrosis score,aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST-to-platelet-ratio index(APRI),and fibrosis-4 on the day before(T0)and following treatment for six months(T1).We also performed transient elastography at T0 and T1.RESULTS Add-on therapy resulted in improved glycemic control and reduced fasting blood glucose in both groups.Of note,following treatment for six months,a reduction of FLI and APRI,as well as of the FibroScan result,was reported in patients treated with SGLT2-I,but not in the OTHER group;furthermore,in the SGLT2-I group,we reported lower circulating levels of interleukin(IL)-1β,IL-6,tumor necrosis factor,vascular endothelial growth factor,and monocyte chemoattractant protein-1,and higher levels of IL-4 and IL-10.We did not observe any modification in circulating interleukins in the OTHER group.Finally,serum HNE-and MDA-protein adducts decreased significantly in SGLT2-I rather than OTHER patients and correlated with liver steatosis and fibrosis scores.CONCLUSION The present data indicate that treatment with SGLT2-I in patients with T2D and NAFLD is associated with improvement of liver steatosis and fibrosis markers and circulating pro-inflammatory and redox status,more than optimizing glycemic control. | Francesco Bellanti Aurelio Lo Buglio MichałDobrakowski Aleksandra Kasperczyk Sławomir Kasperczyk Palok Aich Shivaram P Singh Gaetano Serviddio Gianluigi Vendemiale | 2022 | World Journal of Gastroenterology2022，28，26： | 3 |
| 2 | Comparison of 3,000 and 5,000 IU aXa/day certoparin in the prevention of deep-vein thrombosis after total hip replacement显示文摘 | Bramlage P Michaelis HC Melzer N | | 0，，01： | 1 |
| 3 | Minimised gear lubrica-tion by a minimum oil/air flow rate显示文摘 | Hohn B R Michaelis K Otto H P | 2009 | Wear2009，266，34： | 1 |
| 4 | Highly isotopically depteted isoprenoids:Molecular markers for ancient methane venting 显示文摘 | Thlel V Peckmann J Seffert R Wehrung P Reitner J Michaelis W | 1999 | Geochim Cosmochim Acta1999，63，2324： | 1 |
| 5 | A solid polymer electrolyte-- based ethanol gas sensor 显示文摘 | Millet P Michas A Durand R | 1996 | Journal of Applied Electrochemistry1996，26，9： | 1 |
| 6 | Raman spectroscopy as a morphological probe for TiO2 aerogels 显示文摘 | Sean K Fred H P Micha T | 1997 | J Phys Chem B1997，101，14： | 1 |
| 7 | Glycyrrhizin exerts antioxidative effects in H5N1influenza A virus-infected cells and inhibits virus replication and pro-inflammatory gene expression显示文摘 | Michaelis M Geiler J Naczk P | 2011 | PLoS One2011，6，19： | 1 |
| 8 | A model of non-isothermal degradation of nutrients, pigments and enzymes显示文摘 | MARIA G C MICHA P | 2004 | Journal of the Science of Food and Agriculture2004，84，： | 1 |
| 9 | The contagion effect of low-quality audits 显示文摘 | Francis J R Michas P N | 2013 | Accounting Review2013，88，2： | 1 |
| 10 | Determination and comparison of process-and quality-characteristics of injection-compression moulded polymer optics 显示文摘 | Hopmann Ch Michaeli W Hessner S Walach P | 2011 | Nanosystems2011，3，3： | 1 |
| 11 | Kinetics and yields for the formation of coloured and aromatie thermal degradation products of annatto in foods显示文摘 | Michae J Scotter Laurence Castle Graeme P Appleton | 2001 | Food Chemistry2001，74，： | 1 |
| 12 | Raman spectroscopy as a morphological probe for TiO2 aerogels显示文摘 | SEAN K FRED H P MICHA T | 1997 | J Phys Chem B1997，101，： | 1 |
| 13 | Building learning organizations:the design and implementation of organizational mechanism显示文摘 | Raanan L Micha P | 1996 | Journal of Applied Behavioral Science1996，，32： | 1 |
| 14 | The modular adaptor protein ARH is required for low density lipoprotein (LDL) binding and internalization but not for LDL receptor clustering incoated pits 显示文摘 | Michaely P Li WP Anderson RG | 2004 | J Biol Chem2004，279，34： | 1 |
| 15 | Does fusion improve the outcome after decompressive surgery for lumbar spinal stenosis?a twoyear follow-up study involving 5390 patients显示文摘 | Frsth P Michaёlsson K Sandén B | 2013 | Bone Joint J2013，95，7： | 1 |
| 16 | Evolving antican- cer drug valproic acid:insights into the mechanism and clinical studies显示文摘 | Blaheta R A Michaelis M Driever P H | 2005 | Med Rev2005，25，4： | 1 |
| 17 | Emphusem-atous Pyelonephritis显示文摘 | Michaeli J Mogle P Perlberg S | | 0，，02： | 1 |
| 18 | Highly isotopically depleted isoprenoids: Molecular markers for micient methane venting显示文摘 | Thiel V Peckmann J Seifert R Wehrung P Reitner J Michaelis W | 1999 | Geochim Cosmochim Acta1999，63，2324： | 1 |
| 19 | Immunologic study of artificial skin usual in the treatment of thermal injuries显示文摘 | Dov Michaeli Michael M P | 1990 | Journal of Burn care and Rehabilitation1990，11，： | 1 |
| 20 | Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia 显示文摘 | Jones C Garuti R Michaely P | 2007 | J Clin Invest2007，117，1： | 1 |
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