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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Clinical implication of 14-3-3 epsilon expression in gastric cancer显示文摘AIM:To evaluate for the first time the protein and mRNA expression of 14-3-3εin gastric carcinogenesis.METHODS:14-3-3εprotein expression was determined by western blotting,and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue samples.RESULTS:Authors observed a significant reduction of 14-3-3εprotein expression in gastric cancer(GC)samples compared to their matched non-neoplastic tissue.Reduced levels of 14-3-3εwere also associated with diffuse-type GC and early-onset of this pathology.Our data suggest that reduced 14-3-3εmay have a role in gastric carcinogenesis process.CONCLUSION:Our results reveal that the reduced 14-3-3εexpression in GC and investigation of 14-3-3ε interaction partners may help to elucidate the carcino-genesis process. | Mariana Ferreira Leal Danielle Queiroz Calcagno Smia Demachki Paulo Pimentel Assumpo Roger Chammas Rommel Rodríguez Burbano Marília de Arruda Cardoso Smith | 2012 | World Journal of Gastroenterology2012，18，13： | 6 |
| 3 | Acute effects of Helicobacter pylori extracts on gastric mucosal blood flow in the mouse显示文摘AIM: To investigate the mechanisms underlying the reduction in gastric blood flow induced by a luminal water extract of Helicobacter pylori (HPE). METHODS: The stomachs of isourane-anesthetized mice were exteriorized, and the mucosal surface exposed. Blood flow was measured with the laser-Doppler technique, and systemic arterial blood pressure monitored. C57BL/6 mice were exposed to water extract produced from H pylori strain 88-23. To investigate the role of a nerveor iNOS-mediated pathway, we used intraluminal lidocaine and iNOS-/-mice. Blood flow response to the endogenous nitric oxide synthase inhibitor asymmetric dimethyl arginine (ADMA) was also assessed. RESULTS: In wild-type mice, HPE decreased mucosal blood flow by approximately 30%. This reduction was abolished in iNOS-defi cient mice, and by pre-treatment with lidocaine. Luminally applied ADMA resulted in reduction in blood flow similar to that observed in wild-type mice exposed to HPE. CONCLUSION: A H pylori water extract reduces gastric mucosal blood flow acutely through iNOS- and nerve-mediated pathways. | Johanna Henriksns Christer Atuma Mia Phillipson Stellan Sandler Lars Engstrand Lena Holm | 2009 | World Journal of Gastroenterology2009，15，2： | 2 |
| 4 | Two physical mechanisms for boosting the quality factor to cavity volume ratio of photonic crystal microcavities显示文摘 | LALANNE P MIAS S HUGONIN J P | 2004 | Optics Express2004，12，45： | 1 |
| 5 | Epigenetic Inactivation of RAS association domain family protein I(RASSF1A) in Malignant Cutaneous Melanoma 显示文摘 | MIA S STELLA T REINHARD D | 2003 | Cancer Research2003，63，： | 1 |
| 6 | Identification of the virus of rabbit haemorrhagic in Tunisia显示文摘 | Bouslama A De Mia G M Hammami S | 1996 | Vet Res1996，138，： | 1 |
| 7 | First assessment of classical swine fever marker vaccine can didate CP7 E2alf for oral immunization of wild boar under field conditions显示文摘 | Feliziani F Blome S Petrini S Giammarioli M Iscaro C Scveri G Convito L Pietschmann J Beer M De Mia G M | 2014 | Vaccine2014，32，18： | 1 |
| 8 | Microstructural and mechanical eharacterization of postweld heattreated thermite weld in rails显示文摘 | Milan T Jovanovi c Mia(s) Todorovi c | 1999 | Materials Characterization1999，43，： | 1 |
| 9 | Specialized education for patients with Psoriasis 显示文摘 | Skarpathiotakis Mia Fairlie C Ryan S | 2006 | Dermatol Nuts2006，18，4： | 1 |
| 10 | New research issues in sous-vide cooking显示文摘 | MIA S | 1996 | Trends in Food Science and Technology1996，，71： | 1 |
| 11 | Genotypic characterization ofSalmonella by multilocus sequence typing, pulsed-field gel electrophoresis and amplified fragment length polymorphism 显示文摘 | Mia TT Marianne NS Doithe S | 2005 | J Microbiol Meth2005，63，： | 1 |
| 12 | Phasemodulating bistable optically addressed spatial light modulators using wide-switching-angle ferroelectric liquid crystal layer显示文摘 | MIAS S MANOLIS L G COLLINGS N | 2005 | Optical Engineering2005，44，1： | 1 |
| 13 | Waveguide demonstration of a computer-based smart frequency-selective surface显示文摘 | MIAS C HATTAR G J S GAVRIELIDES N | 2005 | Microwave and Optical Technology Letters2005，44，4： | 1 |
| 14 | Evaluation of hormone replacement therapy 显示文摘 | Siddiqui N I Rabman S Mia A R et a| | 2005 | Mymensingh Med J2005，14，2： | 1 |
| 15 | Relationship between tinnitus severity and psychiatric disorders显示文摘 | Sigyn Z Jan S Kajsa Mia H | 2006 | Psychosomatics2006，47，28： | 1 |
| 16 | Use and outcomes of wound drain in spinal fusion for adolescent idiopathic scoliosis显示文摘 | Mohammad D Mia S John PD | | 0，，11： | 1 |
| 17 | Estimation of genetic and phenotypic parameters of some reproductive traits of Black bengal does显示文摘 | Mia M M Khandoker M A M Y Husain S S | 2013 | Ira- nian Journal of Applied Animal Science2013，3，4： | 1 |
| 18 | An optimized protocol for human M2 macrophages using M-CSF and IL- 4/IL-lO/TGF-beta yields a dominant immunosuppressive phenotype显示文摘 | Mia S Warnecke A Zhang XM | 2014 | Scand J Immunol2014，79，5： | 1 |
| 19 | Evaluation of hormone replacement therapy显示文摘 | Siddiqui N I Rahman S Mia A R | 2005 | Mymensingh Med J2005，14，2： | 1 |
| 20 | Evaluation of Hor-mone repla-cementtherapy 显示文摘 | SiddiquiN I Rahman S Mia A R | 2005 | Mymensingh Med J2005，14，2： | 1 |
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