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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Mesenchymal stem cells promote matrix metalloproteinase secretion by cardi- ac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction显示文摘 | Mias C Lairez O Trouche E | 2009 | Stem Cells2009，27，11： | 1 |
| 3 | Ex vivo pretreatment with melatonin improves survival, proangiogenic/mitogenic activity, and efficiency of mesenchymal stem cells injected into ischemic kidney 显示文摘 | Mias C Trouche E Seguelas MH | 2008 | Stem Cells2008，26，： | 1 |
| 4 | First assessment of classical swine fever marker vaccine can didate CP7 E2alf for oral immunization of wild boar under field conditions显示文摘 | Feliziani F Blome S Petrini S Giammarioli M Iscaro C Scveri G Convito L Pietschmann J Beer M De Mia G M | 2014 | Vaccine2014，32，18： | 1 |
| 5 | Evaluation of alginate micro- spheres for mesenchymal stem cell engraftment on solid organ 显示文摘 | Trouche E Fullana SG Mias C | 2010 | Cell Transplant2010，19，12： | 1 |
| 6 | Varactor tunable frequency selective absorber显示文摘 | Mias C | 2003 | Electr Lett2003，39，14： | 1 |
| 7 | Microstructural and mechanical eharacterization of postweld heattreated thermite weld in rails显示文摘 | Milan T Jovanovi c Mia(s) Todorovi c | 1999 | Materials Characterization1999，43，： | 1 |
| 8 | Specialized education for patients with Psoriasis 显示文摘 | Skarpathiotakis Mia Fairlie C Ryan S | 2006 | Dermatol Nuts2006，18，4： | 1 |
| 9 | Frequency selective absorption using lumped element frequency selective surfaces显示文摘 | MIAS C | 2003 | Electronics Letters2003，39，11： | 1 |
| 10 | Frequecny selective surfaces loaded with surface-mount reactive components显示文摘 | MIAS C | 2003 | Electroncs Letters2003，39，9： | 1 |
| 11 | Waveguide and free-space demonstration of tunable frequency selective surfaces 显示文摘 | MIAS C | 2003 | Electronics Letters2003，39，11： | 1 |
| 12 | Effect of Material Properties on Long-Term Deflection of GFRP Reinforced Concrete Beams 显示文摘 | Mias C Torres L Turon A | 2013 | Construction and Building Material2013，，41： | 1 |
| 13 | Varactor tunable frequency selective absorber显示文摘 | MIAS C | 2003 | Electronics Letters2003，39，14： | 1 |
| 14 | Earthquake devastation and recovery in tourism:The Taiwan case显示文摘 | Huang J H Mia J C H | 2002 | Tourism Management2002，23，2： | 1 |
| 15 | Demonstration of wideband tuning of frequency-selective surfaces in a waveguide setup 显示文摘 | MIAS C | 2005 | Microwave and optieal technology letters2005，44，5： | 1 |
| 16 | Frequency selective surfaces loaded with surface-mount reactive components 显示文摘 | MIAS C | 2003 | Electron Lett2003，39，9： | 1 |
| 17 | Waveguide demonstration of a computer-based smart frequency-selective surface显示文摘 | MIAS C HATTAR G J S GAVRIELIDES N | 2005 | Microwave and Optical Technology Letters2005，44，4： | 1 |
| 18 | Waveguide and free-space demonstration of tunable frequency selective surface 显示文摘 | MIAS C | 2003 | Electron Lett2003，39，11： | 1 |
| 19 | Varactor-tunable and dipole-grid-based frequency-selective surface 显示文摘 | MIAS C | 2004 | Microw Opt Technol Lett2004，43，6： | 1 |
| 20 | Characterization of hTERT - immortalized osteoblast cell lines generated from wild - type and connexin43 -null mouse calvaria显示文摘 | Mia M Marcia U M David C | 2010 | Am J Physiol Cell Physiol2010，299，： | 1 |
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