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| 1 | Recent progress on nanoparticle-based drug delivery systems for cancer therapy显示文摘The development of cancer nanotherapeutics has attracted great interest in the recent decade. Cancer nanotherapeutics have overcome several limitations of conventional therapies, such as nonspecific biodistribution, poor water solubility, and limited bioavailability. Nanoparticles with tuned size and surface characteristics are the key components of nanotherapeutics, and are designed to passively or actively deliver anti-cancer drugs to tumor cells. We provide an overview of nanoparticle-based drug delivery methods and cancer therapies based on tumor-targeting delivery strategies that have been developed in recent years. | Yanru Xin Mingming Yin Liyuan Zhao Fanling Meng Liang Luo | 2017 | Cancer Biology & Medicine2017，14，3： | 10 |
| 2 | Recent progress of nanotechnology-based theranostic systems in cancer treatments显示文摘Theranostics that integrates therapy and diagnosis in one system to achieve accurate cancer diagnosis and treatment has attracted tremendous interest,and has been recognized as a potential breakthrough in overcoming the challenges of conventional oncotherapy.Nanoparticles are ideal candidates as carriers for theranostic agents,which is attributed to their extraordinary physicochemical properties,including nanoscale sizes,functional properties,prolonged blood circulation,active or passive tumor targeting,specific cellular uptake,and in some cases,excellent optical properties that ideally meet the needs of phototherapy and imaging at the same time.Overall,with the development of nanotechnology,theranostics has become a reality,and is now in the transition stage of'bench to bedside.'In this review,we summarize recent progress on nanotechnology-based theranostics,i.e.,nanotheranostics,that has greatly assisted traditional therapies,and has provided therapeutic strategies emerging in recent decades,as well as'cocktail'theranostics mixing various treatment modalities. | Ying Xue Yuting Gao Fanling Meng Liang Luo | 2021 | Cancer Biology & Medicine2021，18，2： | 3 |
| 3 | Reactive power optimization based on genetic algorithm显示文摘 | Zhang Haibo Zhang Lizi Meng Fanling | 1998 | IEEE Trans on Power System1998，2，18： | 1 |
| 4 | Investigation of Voids in Polyacrylonitrile Fibers by USAXS and SAXS显示文摘The void structure of polyacrylonitrile(PAN)fibers was investigated using ultra-small angle X-ray scat-tering(USAXS)and small angle X-ray scattering(SAXS).A quantitative method was developed to analyze connected USAXS/SAXS data and thus determine the void parameters of PAN fibers.The results showed that voids affected the mechanical performance of PAN fibers and were present throughout the entire wet-spinning process.When the abso-lute quantity and size of voids decreased,the tensile strength and modulus of PAN fibers increased.The void para-meters were optimized by controlling the production process,and thus the tensile strength and modulus of PAN fibers were increased.The method for analyzing the void structure developed in this study is useful for analyzing voids over with larger size range,as well as the effect of the void structure on the mechanical performance of fibers. | TANG Haitong MENG Fanling LIU Yan JIN Shi WANG Xiaodong GAO Zhongmin CHE Xiaolei | 2019 | Chemical Research in Chinese Universities2019，35，6： | 1 |
| 5 | miR-133a suppresses ovarian cancer cell proliferation by directly targeting insulin-like growth factor 1 receptor显示文摘 | Jinling Guo Bairong Xia Fanling Meng Ge Lou | 2014 | Tumor Biology2014，，2： | 1 |
| 6 | The Long-Term Efficacy of Neoadjuvant Chemotherapy Followed by Radical Hysterectomy Compared With Radical Surgery Alone or Concurrent Chemoradiotherapy on Locally Advanced-Stage Cervical Cancer显示文摘 | Mingzhu Yin Falin Zhao Ge Lou Haiyu Zhang Meng Sun Cong Li Yan Hou Xia Li Fanling Meng Xiuwei Chen | 2011 | International Journal of Gynecological Cancer2011，，1： | 1 |
| 7 | Preparation of nano- iron oxide red pigment powders by use of cyanided tailings显示文摘 | Li Dengxin Gao Guolong Meng Fanling | 2008 | Jour- nal of Hazardous Materials2008，155，12： | 1 |
| 8 | Preparation of nano-iron oxide red pigment powders by use of cyanided tailings 显示文摘 | Li Dengxin Gao Guolong Meng Fanling | 2008 | Journal of Hazardous Materials2008，155，12： | 1 |
| 9 | Time-Programmed Delivery of Sorafenib and Anti-CD47 Antibody via a Double-Layer-Gel Matrix for Postsurgical Treatment of Breast Cancer显示文摘The highly immunosuppressive microenvironment after surgery has a crucial impact on the recurrence and metastasis in breast cancer patients.Programmable delivery of immunotherapy-involving combinations through a single drug delivery system is highly promising,yet greatly challenging,to reverse postoperative immunosuppression.Here,an injectable hierarchical gel matrix,composed of dual lipid gel(DLG)layers with different soybean phosphatidylcholine/glycerol dioleate mass ratios,was developed to achieve the time-programmed sequential delivery of combined cancer immunotherapy.The outer layer of the DLG matrix was thermally responsive and loaded with sorafenib-adsorbed graphene oxide(GO)nanoparticles.GO under manually controlled near-infrared irradiation generated mild heat and provoked the release of sorafenib first to reeducate tumor-associated macrophages(TAMs)and promote an immunogenic tumor microenvironment.The inner layer,loaded with anti-CD47 antibody(aCD47),could maintain the gel state for a much longer time,enabling the sustained release of aCD47 afterward to block the CD47-signal regulatory proteinα(SIRPα)pathway for a long-term antitumor effect.In vivo studies on 4T1 tumor-bearing mouse model demonstrated that the DLG-based strategy efficiently prevented tumor recurrence and metastasis by locally reversing the immunosuppression and synergistically blocking the CD47-dependent immune escape,thereby boosting the systemic immune responses. | Liping Huang Yiyi Zhang Yanan Li Fanling Meng Hongyu Li Huimin Zhang Jiasheng Tu Chunmeng Sun Liang Luo | 2021 | Nano-Micro Letters2021，13，9： | 1 |
| 10 | Effects of microscopic pore structure heterogeneity on the distribution and morphology of remaining oil显示文摘Waterflooding experiments were performed using Micro-CT on four cores of different pore structures from Donghe sandstone reservoirs in the Tarim Basin. The water, oil and grains were accurately separated by the advanced image processing technology, the pore network model was established, and parameters such as the number of throats and the throat size distribution were calculated to characterize the microscopic heterogeneity of pore structure, the flow of oil phase during displacement, and the morphology and distribution of remaining oil after displacement. The cores with the same macroscopic porosity-permeability have great differences in microscopic heterogeneity of pore structure. Both macro porosity-permeability and micro heterogeneity of pore structure have an influence on the migration of oil phase and the morphology and distribution of remaining oil. When the heterogeneity is strong, the water phase will preferentially flow through the dominant paths and the remaining oil clusters will be formed in the small pores. The more the number of oil clusters(droplets) formed during displacement process, the smaller the average volume of cluster is, and the remaining oil is dominated by the cluster continuous phase with high saturation. The weaker the heterogeneity, the higher the pore sweep efficiency is, and the remaining oil clusters are mainly trapped in the form of non-continuous phase. The distribution and morphology of micro remaining oil are related to the absolute permeability, capillary number and micro-heterogeneity. So, the identification plate of microscopic residual oil continuity distribution established on this basis can describe the relationship between these three factors and distribution of remaining oil and identify the continuity of the remaining oil distribution accurately. | LI Junjian LIU Yang GAO Yajun CHENG Baoyang MENG Fanle XU Huaimin | 2018 | Petroleum Exploration and Development2018，45，6： | 1 |
| 11 | Clinical Significance of Astrocyte Elevated Gene-1 Expression in Human Epithelial Ovarian Carcinoma显示文摘 | Fanling Meng Chang Luo Lihua Ma Yuanlong Hu Ge Lou | 2011 | International Journal of Gynecological Pathology2011，，2： | 1 |
| 12 | Enhanced tensile ductility of tungsten microwires via high-density dislocations and reduced grain boundaries显示文摘Despite being strong with many outstanding physical properties,tungsten is inherently brittle at room temperature,restricting its structural and functional applications at small scales.Here,a facile strategy has been adopted,to introduce high-density dislocations while reducing grain boundaries,through electron backscatter diffraction(EBSD)-guided microfabrication of cold-drawn bulk tungsten wires.The designed tungsten microwire attains an ultralarge uniform tensile elongation of~10.6%,while retains a high yield strength of~2.4 GPa.in situ TEM tensile testing reveals that the large uniform elongation of tungsten microwires originates from the motion of pre-existing high-density dislocations,while the subsequent ductile fracture is attributed to crack-tip plasticity and the inhibition of grain boundary cracking.This work demonstrates the application potential of tungsten microcomponents with superior ductility and workability for micro/nanoscale mechanical,electronic,and energy systems. | Chaoqun Dang Weitong Lin Fanling Meng Hongti Zhang Sufeng Fan Xiaocui Li Ke Cao Haokun Yang Wenzhao Zhou Zhengjie Fan Ji-jung Kai Yang Lu | 2021 | Journal of Materials Science & Technology2021，，36： | 0 |
| 13 | Numerical Simulation Study on the Effect of Horizontal Well Reservoir Stimulation for Gas Hydrate Production显示文摘A new gas hydrate reservoir stimulation method of in-situ fracturing with transient heating is proposed, in line with analysis of the technological bottlenecks faced by marine gas hydrate production. This method injects the developed chemical reagents into a hydrate reservoir through hydraulic fracturing, releasing heat during the chemical reaction to increase the hydrate decomposition rate. The chemical reaction product furthermore has a honeycomb structure to support fractures and increase reservoir permeability. Based on the geological model of natural gas hydrate in the South China Sea, three development methods are simulated to evaluate hydrate production capacity, consisting of horizontal well, fractured horizontal well and in-situ fracturing with transient heating well. Compared with the horizontal well, the simulation results show that the cumulative gas production of the fractured horizontal well in one year is 7 times that of the horizontal well, while the cumulative gas production of in-situ fracturing with transient heating well is 12 times that of the horizontal well, which significantly improves daily efficiency and cumulative gas production. In addition, the variation patterns of hydrate saturation and temperature-pressure fields with production time for the three exploitation plans are presented, it being found that three sensitive parameters of fracture conductivity, fracture half-length and fracture number are positively correlated with hydrate production enhancement. Through the simulations, basic data and theoretical support for the optimization of gas hydrate reservoir stimulation scheme has been provided. | LI Xiaoyang TIAN Yingying ZHANG Xin SONG Gang ZHAO Ming LIANG Jinqiang HUANG Wei MENG Fanle | 2022 | Acta Geologica Sinica(English Edition)2022，96，2： | 0 |
| 14 | Cu/Cr co-stabilization mechanisms in a simulated Al_(2)O_(3)-Fe_(2)O_(3)-Cr_(2)O_(3)-CuO waste system显示文摘Chromium slag usually contains various heavy metals,making its safe treatment difficult.Glassceramic sintering has been applied to resolve this issue and emerged as an effective method for metal immobilization by incorporating heavy metals into stable crystal structures.Currently,there is limited knowledge about the reaction pathways adopted by multiple heavy metals and the co-stabilization functions of the crystal structure.To study the Cu/Cr co-stabilization mechanisms during thermal treatment,a simulated system was prepared using a mixture with a molar ratio of Al_(2)O_(3):Fe_(2)O_(3):Cr_(2)O_(3):CuO=1:1:1:3.The samples were sintered at temperatures 600–1300℃ followed by intensive analysis of phase constitutions and microstructure development.A spinel phase(CuFe_(x)Al_(y)Cr_(2–x–y)O_(4))started to generate at 700℃ and the incorporation of Cu/Cr into the spinel largely complete at 900℃,although the spinel peak intensity continued increasing slightly at temperatures above 900℃.Fe_(2)O_(3)/Cr_(2)O_(3) was more easily incorporated into the spinel at lower temperatures,while more Al_(2)O_(3) was gradually incorporated into the spinel at higher temperatures.Additionally,sintered sample microstructures became more condensed and smoother with increased sintering temperature.Cu/Cr leachability substantially decreased after Cu/Cr incorporation into the spinel phase at elevated temperatures.At 600℃,the leached ratios for Cu and Cr were 6.28%and 0.65%,respectively.When sintering temperature was increased to 1300℃,the leached ratios for all metal components in the system were below 0.2%.This study proposes a sustainable method for managing Cu/Cr co-exist slag at reasonable temperatures. | Fanling Meng Yunxue Xia Jianshuai Zhang Dong Qiu Yaozhu Chu Yuanyuan Tang | 2021 | Frontiers of Environmental Science & Engineering2021，15，6： | 0 |
| 15 | Polydiacetylene-based poly-ion complex enabling aggregation-induced emission and photodynamic therapy dual turn-on for on-demand pathogenic bacteria elimination显示文摘Poly-ion complex(PIC)integrating non-antibiotic theranostics holds great promise in the combat against drug-resistant bacteria.Photosensitizers with aggregation-induced emission(AIE)characteristic are particularly intriguing theranostic agents,but incorporating them into antibacterial PIC to enable both fluorescence and reactive oxygen species(ROS)generation turn-on is deemed a great challenge.Here we report the development of a PIC that can dually boost the fluorescence and ROS generation in the presence of pathogen bacteria.The PIC is constructed based on an anionic polydiacetylene poly(deca-4,6-diynedioic acid)(PDDA),which completely degrades in the presence of ROS.A cationic polymer quaternized poly(2-(dimethylamino)ethyl methacrylate)(PQDMA)that can disrupt bacterial membrane is co-loaded together with a highly efficient AIE photosensitizer TPCI in the PIC.PIC is nonfluorescent initially in that PDDA can quench the AIE of TPCI in PIC.When pathogenic bacteria are present,they can disturb the assembly of PIC to release TPCI,whose fluorescence turns on sensitively to indicate the existence of bacteria.The on-demand irradiation can be subsequently applied to excite TPCI,which generates ROS to degrade PDDA and deform the PIC.As a result,TPCI and PQDMA are completely released to eliminate bacteria through a synergy of turned-on photodynamic therapy(PDT)and membrane disruption.The highly efficient detection and inhibition against both Gramnegative and Gram-positive bacteria have validated this polydiacetylene-based PIC system as an effective non-antibiotic antibacterial theranostic platform as well as a new strategy to enable“turn-on”fluorescence sensing and imaging of AIE fluorophores. | Sidan Tian Yuan Lu Zhenyan He Qiang Yue Zhiyong Zhuang Yingzhou Wang Fanling Meng Liang Luo | 2022 | Science China Chemistry2022，65，9： | 0 |
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