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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Relationship of Helicobacterpylori eradication with gastric cancer and gastric mucosal histological changes: a 10-year follow-up study显示文摘 | Zhou Liya Lin Sanren Ding Shigang Huang Xuebiao Jin Zhu Cui Rongli Meng Lingmei Li Yuan Zhang Li Guo Changji Xue Yan Yan Xiu'e Zhang Jing | 2014 | Chinese Medical Journal2014，，8： | 28 |
| 3 | Overview on current criteria for heavy metals and its hint for the revision of soil environmental quality standards in China显示文摘Following rapid social and economic development over the past several decades, soil pollution by heavy metals(HMs) has been both serious and widespread in China. The Soil Environmental Quality Standards(SEQSs) in China(GB 15618-1995) have been introduced to encourage and enforce sustainable soil HM management. However, in recent years, HM contents in soils have frequently been found to exceed their associated standard values, while the crops growing on them might still meet regulatory standards, and vice versa. There is thus growing awareness that GB 15618-1995 does not effectively regulate current soil HM pollution, as it has encountered bottlenecks, and disappointing outcomes caused by poor execution along with deficiencies and gaps in the policies. However, due to the deficiency of scientific research about relationships between soil HM concentrations and their ecological or human health effects, the development of SEQSs in China is still greatly restricted. This paper discusses international SEQSs of HMs as well their development in China over time, then examines current Chinese SEQSs to demonstrate their potential regulatory deficiencies by referring to international SEQSs. The corresponding legislative policies are described, and scientific information or responses are outlined for maintaining soil environmental quality. China's experience has shown that policy and science can be linked to work in tandem to better understand and manage soil quality issues. | CHEN Shi-bao WANG Meng LI Shan-shan ZHAO Zhong-qiu E Wen-di | 2018 | Journal of Integrative Agriculture2018，17，4： | 14 |
| 4 | 非甾体抗炎药应用中,环氧合酶2、不对称二甲基精氨酸与心血管危害的关系显示文摘已有大规模、安慰剂对照试验确定了非甾体类抗炎药(nonsteroidal anti—inflammatory drugs,NSAIDs)具有心血管危害性:这归因于环氧合酶2(cyclooxygenase,COX-2)的心脏保护产物受到抑制,尤其是前列环素(prostacyclin,PG12)。NSAID降低心脏保护作用的另一种机制可能是通过增强肾脏中甲基精氨酸的形成来限制一氧化氮在整个脉管系统中的作用。 | Ricciotti E Castro C Tang SY Briggs WTE West JA Malik D Rhoades SD Meng H Li X Lahens NF Sparks JA Karlson EW Weljie AM Griffin JL FitzGerald GA6 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 3 |
| 5 | China’s provincial CO 2 emissions embodied in international and interprovincial trade显示文摘 | Ju’e Guo Zengkai Zhang Lei Meng | 2011 | Energy Policy2011，，： | 2 |
| 6 | Enhancing the mineral and vitamin content of wheat and maize through plant breeding显示文摘 | Ortiz Monasterio J I Palacios-Rojas N Meng E | 2007 | Journal of Cereal Science2007，46，3： | 1 |
| 7 | Spontaneous activity of mouse detrusor smooth muscle and the effects of the urothelium 显示文摘 | Meng E Young JS Brading AF | 2008 | Neurourol Urodyn2008，27，： | 1 |
| 8 | Utilization of mycorrhizal fungi in citrus nurseries显示文摘 | Menge J A Lembright H Johnon E L V | 1977 | Proc Int Soc Citric1977，1，： | 1 |
| 9 | The neuronal sortilinrelated receptor SORL1 is genetically associated with Alzheimer disease显示文摘 | Rogaeva E Meng Y Lee J H | 2007 | Nat Genet2007，39，2： | 1 |
| 10 | Validating evapotranspiraiton equations using Bowen Ratio in New Brunswick, Maritime, Canada 显示文摘 | XING Z H CHOW L E MENG F R | 2008 | Sensors2008，8，： | 1 |
| 11 | Trends in the incidence and mortality of coronary heart disease in asian pacific region 显示文摘 | MENG K C TAI E | 2013 | Journal of Atherosclerosis and Thrombosis2013，21，： | 1 |
| 12 | Involvement of purinergic neurotransmission in ketamine induced bladder dysfunction显示文摘 | Meng E Chang HY Chang SY | | 0，，03： | 1 |
| 13 | Genetic diversity of Salmonella pathogenicity islands SPI-5 and SPI-6 in Salmonella Newport显示文摘 | Cao G Allard M Strain E Stones R Zhao S Brown E Meng J | 2014 | Foodborne Pathog Dis2014，11，10： | 1 |
| 14 | Provenance, transport and characteristics of modem aeolian dust in western Gansu Prov- ince,China,and interpretation of the Quaternary loess record显示文摘 | Derbyshire E Meng X M Kemp R A | 1998 | Journal ofAridEnvironments1998，39，2： | 1 |
| 15 | Intracanopy variation in leaf morphology and physiology in dominant shrubs of Florida's xeric uplands 显示文摘 | Stephens E L Saha S Menges E S | 2009 | Botany-Botanique2009，87，1： | 1 |
| 16 | Tucker,Sequence Stratigraphy,sea level changes and depositional systems in the Cambro-Ordovician of the North China carbonate platform显示文摘 | Meng Xianghua Ge Ming M E | 1977 | Sedimentary Geology1977，114，： | 1 |
| 17 | Regulation of cellfate decision of undifferentiated spermatogonia by GDNF显示文摘 | Meng X J Lindahl M Hyvonen M E | 2000 | Science2000，287，5457： | 1 |
| 18 | On fuzzy ideals in BCK/BCI-algebras显示文摘 | Meng J Guo X E | 2005 | Fuzzy Sets and Systems2005，149，： | 1 |
| 19 | Hedgehog signaling pathway regu- lates the growth of ovarian cancer spheroid forming cells 显示文摘 | Ray A Meng E Reed E | 2011 | Int J Oncol2011，39，4： | 1 |
| 20 | Mycobacterium tuberculosis induces interleukin-32 production through a caspase-1/IL-18/interferon-γ-dependent mechanism显示文摘 | Netea M G Azam T Lewis E C Joosten L A Wang M Langenberg D Meng X Chan E D Yoon D Y Ottenhoff T Kim S H and Dinarello C A | | 0，，08： | 1 |
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