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| 1 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 2 | Can illegal corporate behavior be predicted: An event history analysis显示文摘 | Baucus Melissa S Near Janet P | | 0，，： | 1 |
| 3 | Design and projec- ted performance of a flapping foil AUV显示文摘 | STEPHEN L VICTOR P MELISSA F | 2004 | IEEE Journal of Oceanic Engineering2004，29，3： | 1 |
| 4 | Characterization of the last deglacial transition in tropical East Afri显示文摘 | Melissa A B Thomas C J Josef P W | 2014 | Palaeogeography Palaeoclimatology Palaeoecology2014，409，： | 1 |
| 5 | Post-cesarean related infection and vaginal preparation with povidone-iodine revisited显示文摘 | Melissa A G Samuel D P | 2002 | Prim Care Update Ob/Gyns2002，9，6： | 1 |
| 6 | Pancreatic Cancer: Medical Management (Novel Chemotherapeutics)显示文摘 | David Páez Melissa J. Labonte Heinz-Josef Lenz | 2012 | Gastroenterology Clinics of North America2012，，1： | 1 |
| 7 | ' Reversine' and Its 2-Substituted Adenine Derivatives as Potent and Selective A3 Adenosine Receptor Antagonists显示文摘 | Melissa P Jiang J Athena M K | 2005 | J Med Chem2005，45，： | 1 |
| 8 | PME- 1 protects extracellular signal-regulated kinase pathway activity t-rom protein phosphatase 2A-mediated inactivation in human malignant glioma 显示文摘 | Pietri P Melissa R J Sari V | 2009 | Cancer Res2009，69，： | 1 |
| 9 | Enzymeatre synthesis of medium chain mono-glycerides in a solvent-free system显示文摘 | MARTA A P L MELISSA E D A | 2002 | Applied Biochemistry and Biotechnology2002，98，： | 1 |
| 10 | “Revers-ine” and Its 2-Substituted Adenine Derivatives as Po-tent and Selective A3 Adenosine Receptor Antago-nists 显示文摘 | MELISSA P JIANG J ATHENA M K | 2005 | J- Med Chem2005，48，： | 1 |
| 11 | Mycosis fungoides with large cell transformation: clinicopathological features and prognostic factors显示文摘 | Melissa P Myskowski P L Horwitz S M | 2014 | Pathology2014，46，： | 1 |
| 12 | Influence of sodium currents on speeds of traveling wave fronts in synoptically coupled neuronal networks显示文摘 | ZHANG L H WU P S Melissa Anne Stoner | 2010 | Physica D2010，239，1： | 1 |
| 13 | Dexmedetomidine infusion for analgesia and prevention of emergence agita- tion in children with obstructive sleep apnea syndrome under- going tonsillectomy and adenoidectomy显示文摘 | Anuradha P Melissa D Minh CJ | 2010 | Anesth Analg2010，111，4： | 1 |
| 14 | Portable ultrasonography in mass casualty incidents:The CAVEAT examination显示文摘Ultrasonography used by practicing clinicians has been shown to be of utility in the evaluation of time-sensitive and critical illnesses in a range of environments,including pre-hospital triage,emergency department,and critical care settings.The increasing availability of lightweight,robust,user-friendly,and low-cost portable ultrasound equipment is particularly suited for use in the physically and temporally challenging environment of a multiple casualty incident(MCI).Currently established ultrasound applications used to identify potentially lethal thoracic or abdominal conditions offer a base upon which rapid,focused protocols using hand-carried emergency ultrasonography could be developed.Following a detailed review of the current use of portable ultrasonography in military and civilian MCI settings,we propose a protocol for sonographic evaluation of the chest,abdomen,vena cava,and extremities for acute triage.The protocol is two-tiered,based on the urgency and technical difficulty of the sonographic examination.In addition to utilization of well-established bedside abdominal and thoracic sonography applications,this protocol incorporates extremity assessment for long-bone fractures.Studies of the proposed protocol will need to be conducted to determine its utility in simulated and actual MCI settings. | Stanislaw Peter Stawicki James M Howard John P Pryor David P Bahner Melissa L Whitmill Anthony J Dean | 2010 | World Journal of Orthopedics2010，1，1： | 1 |
| 15 | Simultaneous determination of residues of chloramphenicol,thiamphenicol,florfenicol,and florfenicol amine in farmed aquatic species by liquid chromatography/mass spectrometry显示文摘 | Ross A P Melissa C F | 2003 | AOAC Int2003，86，3： | 1 |
| 16 | Dexmedetomidine infusion for analgesia and prevention of emergence agitation in children with obstructive sleep apnea syndrome undergo- ing tonsillectomy and adenoidectomy 显示文摘 | Anuradha P Melissa D Minh C J | 2010 | Anesth Analg2010，111，4： | 1 |
| 17 | Dexmedetomidine infusion for analgesia and prevention of emergence agitation in children with obstractive sleep apnea syndrome undergoing tonsiUectomy and adenoidectomy 显示文摘 | Anuradha P Melissa D Minh CJT | 2010 | Anesthesia An- algosla2010，11，4： | 1 |
| 18 | Electrodeposition of ordered Bi2Te3 nanowire arrays显示文摘 | Amy L P Melissa S S Marisol S | 2001 | J Am Chem Soc2001，123，29： | 1 |
| 19 | Characteristics, Control and Uses of Liquid Streams in Space 显示文摘 | Muntz E P Melissa Ormei | 1985 | AIAA Journal1985，25，5： | 1 |
| 20 | Recombinant DNA Procedures for Producing Small Antimicrobial Cationic Peptides in Bacteria显示文摘 | Kevin L P Melissa H B Robert E W | 1993 | Gene1993，134，1： | 1 |
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